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Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs

Journal of Environmental Sciences 2023年第4期126卷 683-696页

作者： Daojie Li Long Shen Di Zhang Xiaotong Wang Qiankun Wang Wenhao Qin Yun Gao Xiaoping Li Key Lab of Agricultural Animal Genetics Breeding and Reproduction of Ministry of EducationCollege of Animal Science and TechnologyThe Cooperative Innovation Center for Sustainable Pig ProductionHuazhong Agricultural UniversityWuhan 430070China College of Science Huazhong Agricultural UniversityWuhan 430070China College of Engineering The Cooperative Innovation Center for Sustainable Pig ProductionHuazhong Agricultural UniversityWuhan 430070China

Ammonia,a common toxic gas,is not only one of the main causes of haze,but also can enter respiratory tract and directly affect the health of humans and *** was used as an animal model for exploring the molecular mechanism and dose effect of ammonia toxicity to *** this study,the apoptosis of type II alveolar epithelial cells was observed in high ammonia exposure group using transmission electron *** and protein expression analysis using transcriptome sequencing and western blot showed that low ammonia exposure induced T-cell-involved proinflammatory response,but high ammonia exposure repressed the expression of DNA repair-related genes and affected ion ***,high ammonia exposure significantly increased 8-hydroxy-2-deoxyguanosine (8-OHdG) level,meaning DNA oxidative damage *** addition,both low and high ammonia exposure caused oxidative stress in pig *** analysis of transcriptome and metabolome revealed that the up-regulation of LDHB and ND2 took part in high ammonia exposure-affected pyruvate metabolism and oxidative phosphorylation progress,***,oxidative stress mediated ammonia-induced proinflammatory response and apoptosis of porcine *** findings may provide new insights for understanding the ammonia toxicity to workers in livestock farms and chemical fertilizer plants.

关键词： Ammonia Lung proinflammatory response Oxidative stress Apoptosis Energy metabolism

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