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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

引用

Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong Man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

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