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Krüppel-like factor 8 is a potential prognostic factor for pancreatic cancer

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Chinese Medical Journal 2014年第5期127卷 856-859页

作者： Wei Yingxin Chen Ge You Lei Zhao Yupei Department of General Surgery Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100730 China

Background Pancreatic cancer is a lethal disease that is often diagnosed at an advanced *** is a lack of information to predict the prognosis of pancreatic ***üppel-like factor （KLF） 8 has been found to be deregulated in multiple cancers,and its high expression was correlated with poor ***,so far,no information was reported about the expression of KLF8 in pancreatic *** the present study,we investigated,possibly for the first time,the expression of KLF8 in pancreatic cancer samples and analyzed its correlation with clinical parameters and overall survival （OS） *** We used immunohistochemical staining to detect KLF8 in 68 samples from patients who underwent surgery and its correlation with the clinicopathological *** used Kaplan-Meier curve to analyze the relationship between KLF8 expression and the OS *** analysis was performed in addition to multivariate hazard models with clinicopathological features to assess KLF8 as an independent prognostic *** KLF8 was present in the cytoplasm of pancreatic cancer cells and 52.9％ of the 68 cases had positive ***8 expression was not associated with sex,age,tumor location,lymph node stage,and metastasis stage,but was associated with tumor stage （P=0.04）.Kaplan-Meier method demonstrated that patients with negative expression of KLF8 had a better *** univariate and multivariate models,KLF8 was a significant predictor of OS in pancreatic *** Our results revealed that KLF8 may be a potential prognostic factor for pancreatic cancer.

关键词： Krüppel-like factor 8 prognostic factor pancreatic cancer survival

Downregulation of orosomucoid 2 acts as a prognostic factor associated with cancer-promoting pathways in liver cancer

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World Journal of Gastroenterology 2020年第8期26卷 804-817页

作者： Han-Zhang Zhu Wei-Jiang Zhou Ya-Feng Wan Ke Ge Jun Lu Chang-Ku Jia Department of Hepatopancreatobiliary Surgery Hangzhou First People’s HospitalThe Affiliated Hospital of Medical School of Zhejiang University

BACKGROUND Liver cancer has a high mortality and morbidity rate throughout the *** clinical practice,the prognosis of liver cancer patients is poor,and the complex reasons contribute to treatment failures,including fibrosis,hepatitis viral infection,drug resistance and ***,screening novel prognostic biomarkers is of great importance for guiding liver cancer *** genes(ORMs)encode acute phase plasma proteins,including orosomucoid 1(ORM1)and *** studies showed their upregulation upon inflammation,but the specific function of ORMs has not yet been determined,especially in the development of liver *** To determine the expression of ORMs and their potential function in liver *** Analysis of the expression of ORMs in different human tissues was performed on data from the HPA RNA-seq normal tissues *** expression ratio of ORMs was determined using the HCCDB database,including the ratio between liver cancer and other cancers,normal liver and other normal tissues,liver cancer and adjacent normal liver *** of ORM expression in different cancer types was performed using The Cancer Genome Atlas and TIMER *** expression of ORMs in liver tumor tissues and adjacent normal tissues were further confirmed using Gene Expression Omnibus data,including GSE36376 and *** 10-year overall survival(OS),progression-free survival(PFS)and relapse-free survival(RFS)rates between high and low ORM expression groups in liver cancer patients were determined using the Kaplan-Meier plotter *** Set Enrichment Analysis(GSEA)was employed to explore the ORM2-associated signaling *** between ORM2 expression and tumor purity or the infiltration level of macrophages in liver tumor tissues were determined using the TIMER *** correlation between ORM2 gene levels,tumor-associated macrophage(TAM)markers(including CD68 and TGFβ1)and T cell immunosuppression(including CTLA4 and PD-1)in

关键词： Orosomucoid gene Specific expression Downregulation prognostic factor Tumor promoter signaling Immune suppression

Liver dysfunction as a cytokine storm manifestation and prognostic factor for severe COVID-19

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World Journal of Hepatology 2021年第12期13卷 2005-2012页

作者： Gergana Taneva Dimitar Dimitrov Tsvetelina Velikova Department of Gastroenterology Sveta Sofia HospitalSofia 1618Bulgaria Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria

patients with or without preexisting liver disorders,posing a significant complication and mortality *** coronavirus disease 2019(COVID-19),abnormal liver function is typically ***,liver injury may occur because of the treatment as ***,cytokine storm,and hypoxia were identified as the three major factors contributing to liver damage during ***,raised liver enzymes during hospitalizations may be attributed to medications used,as well as sepsis and *** a result,the proportion of hospitalized patients afflicted with COVID-19 and pathological liver biomarkers varies from 14%to 53%.Aminotransferases and bilirubin are found most often ***,increased gamma-glutamyltransferase,alkaline phosphatase,and decreased serum albumin levels are ***,although there is no specific treatment for COVID-19,many of the drugs used to treat the infection are *** this mini-review,we focus on how liver dysfunction can be one of the features associated with the COVID-19 cytokine ***,data show that liver injury can be an independent predictor of severe COVID-19,the need for hospitalization,and death.

关键词： Liver dysfunction Liver damage Cytokine storm prognostic factor COVID-19 Severe COVID-19 SARS-CoV-2 Aspartate aminotransferase Alanine aminotransferase Bilirubin Interleukin-6

An independent prognostic factor for heart failure： sympathetic hyperactivity

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Chinese Medical Journal 2011年第7期124卷 1118-1118页

作者： Kardesoglu, Ejder Isilak, Zafer Uz, Omer Yiginer, Omer Haydarpasa Training Hosp Gulhane Mil Med Acad Dept Cardiol Istanbul Turkey

To the editor： We read with attention the research article titled Long-term prognostic value of analysis of sympathetic drivewith dilated cardiomyopathy, and its prognostic value was assessed in a 54-month follow-up ... 详细信息

关键词： independent prognostic factor heart failure sympathetic hyperactivity

Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

Evaluating the influence of sarcopenia and myosteatosis on clinical outcomes in gastric cancer patients undergoing immune checkpoint inhibitor

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World Journal of Gastroenterology 2024年第8期30卷 863-880页

作者： Gui-Ming Deng Hai-Bin Song Zhong-Ze Du Ying-Wei Xue Hong-Jiang Song Yuan-Zhou Li Department of Gastrointestinal Surgery Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina Department of Radiology Harbin Medical University Cancer HospitalHarbin 150081Heilongjiang ProvinceChina

BACKGROUND The development and progression of gastric cancer(GC)are closely linked to the nutritional status of *** immunotherapy has been demonstrated to be clinically effective,the relationships of sarcopenia and myosteatosis with the use of immune checkpoint inhibitors(ICIs)in patients with gastric cancer remain to be *** We performed a retrospective study of patients who were undergoing immuno-therapy for *** the evaluation of sarcopenia,the optimal cut-off value for the skeletal muscle index was established using receiver operating characteristic analysis of data obtained from pre-treatment computed tomography images at the L3 vertebral *** was defined using the mean skeletal muscle density(SMD),with a threshold value ofprognostic *** were developed to predict the PFS and OS of patients on the basis of the results of multivariate *** We studied 115 patients who were undergoing ICI therapy for GC,of whom 27.4%had sarcopenia and 29.8%had *** with sarcopenia or myosteatosis had significantly shorter PFS and OS than those without these ***,both sarcopenia and myosteatosis were found to be independent predictors of PFS and OS in patients with GC administering an *** prediction models created for PFS and OS were associated with C-indexes of 0.758 and 0.781,*** The presence of sarcopenia or myosteatosis is a reliable predictor of the clinical outcomes of patients with GC who are undergoing treatment with an ICI.

关键词： Gastric cancer Sarcopenia Myosteatosis,Immune checkpoint inhibitor prognostic factor Overall survival Progression-free survival

prognostic factors in Chinese patients with metastatic castration-resistant prostate cancer treated with docetaxel-based chemotherapy

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Asian Journal of Andrology 2013年第1期15卷 110-115页

作者： Yuan-Yuan Qu Bo Dai Yun-Yi Kong Ding-Wei Ye Xu-Dong Yao Shi-Lin Zhang Hai-Liang Zhang Chun-Guang Ma Wei-Yi Yang Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Fudan University Shanghai Medical College Shanghai 200032 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

This study aims to evaluate the potential value of patient characteristics in predicting overall survival （OS） in patients with metastatic castration-resistant prostate cancer （mCRPC） treated with docetaxel-based thermotherapy. A total of 115 patients with mCRPC undergoing a docetaxel q3w regimen were enrolled in this study. A survival analysis was performed using the Kaplan-Meier method. Cox proportional hazards models were used to evaluate the prognostic value of all covariates for OS. OS was also analysed after stratifying patients according to the results of multivariate analysis. The median OS for the entire cohort was 17.0 months. The multivariate analysis showed that the prostate-specific antigen doubling time （PSADT）, baseline haemoglobin （Hb） concentration, alkaline phosphatase （ALP） concentration, cycles of chemotherapy and time to castration resistance were independent prognostic factors of OS. According to the presence of PSADT 〈46.3 days and baseline ALP/〉 110 IU 1-1, all patients were divided into three risk groups： low-risk group （no risk factors）, intermediate-risk group （one risk factor） and high-risk group （two risk factors）. Median OSs for patients in low-, intermediate- and high-risk groups were 28.0 months （95% Ch 23.8-32.2）, 21.0 months （95% Ch 18.9-23.1） and 11.0 months （95% Ch 7.6-14.4）, respectively （P〈O.O01）. In conclusion, PSADT, baseline Hb concentration, ALP concentration, cycles of chemotherapy and time to castration resistance were independent prognostic factors of OS in Chinese patients with mCRPC treated with docetaxel. PSADT combined with the baseline ALP concentration could be a useful risk stratification parameter for evaluating survival outcomes.

关键词： castration-resistant docetaxel metastatic overall survival prognostic factor prostate cancer

prognostic factors for late mortality after liver transplantation for benign end-stage liver disease

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Chinese Medical Journal 2011年第24期124卷 4229-4235页

作者： ZHANG Ying-cai ZHANG Qi LI Hua ZHANG Jian WANG Gen-shu XU Chi YI Shu-hong YI Hui-min CAI Chang-jie LU Min-qiang YANG Yang CHEN Gui-hua Liver Transplantation Center Third Affiliated Hospital of SunYat-sen University Guangzhou Guangdong 510630 China Guangdong Provincial Key Laboratory of Liver Disease Guangzhou Guangdong 510630 China

Background There are increasing numbers of patients who survive more than one year after liver transplantation. Many studies have focused on the early mortality of these patients. However, the factors affecting long-term survival are not fully understood. This study aims to evaluate prognostic factors predicting long-term survival and to explore measures for improving the survival outcomes of patients who underwent liver transplantation for benign end-stage liver diseases. Methods The causes of late death after liver transplantation and potential prognostic factors were retrospectively analyzed for 221 consecutive patients who underwent liver transplantation from October 2003 to June 2008. Twenty-seven variables were assessed using the Kaplan-Meier method, and those variables found to be univariately significant at P〈0.10 were entered into a backward step-down Cox proportional hazard regression analysis to identify the independent prognostic factors influencing the recipients＇ long-term survival. Results Twenty-eight recipients died one year after liver transplantation. The major causes of late mortality were infectious complications, biliary complications, and Hepatitis B virus recurrence/reinfection. After Cox analysis, the five remaining co-variables were： age, ABO blood group, cold ischemia time, post-infection region, and biliary complications. Conclusions The major causes of late mortality were infection, biliary complications and Hepatitis B virus recurrence/reinfection. Five variables （Age, ABO blood group, cold ischemia time, infection, and biliary complications） had significant impacts on patient survival.

关键词： liver transplantation survival benign cause prognostic factor

prognostic factors influencing clinical outcomes of glioblastoma multiforme

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Chinese Medical Journal 2009年第11期122卷 1245-1249页

作者： LI Shou-wei QIU Xiao-guang CHEN Bao-shi ZHANG Wei REN Huan WANG Zhong-cheng JIANG Tao Department of Neurosurgery Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Radiotherapy Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing 100050 China Department of Immunology Harbin Medical University Harbin Heilongjiang 150086 China Beijing-Neurosurgical Institute Beijing 100050 China

Background Glioblastoma multiforme （GBM） is the most malignant kind of astrocytic tumors and is associated with a poor prognosis. In this retrospective study, we assessed the clinical, radiological, genetic molecular and treatment factors that influence clinical outcomes of patients with GBM. Methods A total of 116 patients with GBM who received surgery and radiation between January 2006 and December 2007 were included in this study. Kaplan-Meier survival analysis and Cox regression analysis were used to find the factors independently influencing patients＇ progression free survival （PFS） time and overall survival （OS） time. Results Age, preoperative Karnofsky Performance Scale （KPS） score, KPS score change at 2 weeks after operation, neurological deficit symptoms, tumor resection extent, maximal tumor diameter, involvement of eloquent cortex or deep structure, involvement of brain lobe, Ki-67 expression level and adjuvant chemotherapy were statistically significant factors （P 〈0.05） for both PFS and OS in the univariate analysis. Cox proportional hazards modeling revealed that age 〈50 years, preoperative KPS score 〉80, KPS score change after operation 〉0, involvement of single frontal lobe, non-eloquent area or deep structure involvement, low Ki-67 expression and adjuvant chemotherapy were independent favorable factors （P 〈0.05） for patients＇ clinical outcomes. Conclusions Age at diagnosis, preoperative KPS score, KPS score change at 2 weeks postoperation, involvement of brain lobe, involvement of eloquent cortex or deep structure, Ki-67 expression level and adjuvant chemotherapy correlate significantly with the prognosis of patients with GBM.

关键词： glioblastoma multiforme prognostic factor disease progression survival chemotherapy