检索结果-南通市图书馆

Glucocorticoids-based prodrug design: Current strategies and research progress

Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 45-82页

作者： Hongbing Liu Muse Jia Peifu Xiao Jingxin Gou Tian Yin Haibing He Xing Tang Yu Zhang Department of Pharmaceutics Shenyang Pharmaceutical University School of Chinese Materia Medica Shenyang Pharmaceutical University

Attributing to their broad pharmacological effects encompassing anti-inflammation,antitoxin, and immunosuppression, glucocorticoids(GCs) are extensively utilized in the clinic for the treatment of diverse diseases such as lupus erythematosus, nephritis,arthritis, ulcerative colitis, asthma, keratitis, macular edema, and leukemia. However, longterm use often causes undesirable side effects, including metabolic disorders-induced Cushing's syndrome(buffalo back, full moon face, hyperglycemia, etc.), osteoporosis,aggravated infection, psychosis, glaucoma, and cataract. These notorious side effects seriously compromise patients' quality of life, especially in patients with chronic ***, glucocorticoid-based advanced drug delivery systems for reducing adverse effects have received extensive attention. Among them, prodrugs have the advantages of low investment, low risk, and high success rate, making them a promising *** this review, we propose the strategies for the design and summarize current research progress of glucocorticoid-based prodrugs in recent decades, including polymer-based prodrugs, dendrimer-based prodrugs, antibody-drug conjugates, peptide-drug conjugates,carbohydrate-based prodrugs, aliphatic acid-based prodrugs and so on. Besides, we also raise issues that need to be focused on during the development of glucocorticoid-based prodrugs. This review is expected to be helpful for the research and development of novel GCs and prodrugs.

关键词： Glucocorticoids prodrug design Targeted drug delivery Research progress

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：