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Prevalence and impact of diabetes and prediabetes on presentation and complications of primary hyperaldosteronism at diagnosis

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World Journal of Clinical Cases 2024年第18期12卷 3332-3339页

作者： Debmalya Sanyal Pradip Mukhopadhyay Sujoy Ghosh Department of Endocrinology NHRTIICS&KPC Medical CollegeKolkata 700032West BengalIndia Department of Endocrinology IPGME&R and SSKM HospitalKolkata 700020West BengalIndia Department of Endocrinology IPGME&RKolkata 700020West BengalIndia

BACKGROUND primary hyperaldosteronism(PH)is considered to contribute to increased risk of developing type 2 diabetes mellitus(T2DM)and *** PH and DM are associated with increased risk for hypertension,cardiovascular diseases,and chronic kidney ***,data on prevalence of T2DM and prediabetes in PH,and impact of T2DM and prediabetes on presentation and cardio renal complications in PH at presentation is *** To determine the prevalence of T2DM and prediabetes in PH at diagnosis and impact on presentation and complications of *** A retrospective cohort study was conducted in tertiary care settings in individuals with confirmed diagnosis of PH at *** variables,clinical presentations,duration and degree of hypertension,complications,laboratory parameters including sodium,potassium levels,plasma aldosterone concentration(PAC),plasma renin activity(PRA),and aldosterone to renin ratio(ARR)and cardio-renal parameters were *** was done between three groups:PH with no DM(Group A)or with pre-diabetes(Group B)or with T2DM(Group C).P<0.05 was statistically *** Among 78 individuals with confirmed PH,62%had pre-diabetes or diabetes;with 37%having *** duration of T2DM was 5.97±4.7 *** mean levels of glycaemic parameters among the group A vs B vs C individuals were fasting plasma glucose(mg/dL):87.9±6.5,105.4±9.02,130.6±21.1;post prandial plasma glucose(mg/dL):122.7±9.8,154.9±14,196.7±38.0;glycated haemoglobin(%)(5.3±0.2,5.9±0.2,7.5±0.6,P<0.05),*** was no significant difference in the biochemical parameters(PAC,PRA,ARR,sodium,potassium levels),presentation and complications between the *** renal parameters or degree and duration of hypertension were comparable between the *** Significant prevalence of T2DM and prediabetes in PH at diagnosis does not impact its presentation or *** screening for undetected PH in T2DM and prediabete

关键词： primary hyperaldosteronism Diabetes Prediabetes Hypertension Aldosterone Aldosterone to renin ratio

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Conn’s Syndrome Secondary to Adrenal Adenoma

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Open Journal of Clinical Diagnostics 2016年第4期6卷 47-51页

作者： Sahil N. Fulara Nasir Y. Fulara Department of Medicine Jaslok Hospital and Medical Research Center Mumbai India

primary hyperaldosteronism is not as uncommon as we thought, and by recent estimates the prevalance may be as high as 11% among hypertensives. We present a case of a 33 years old male patient came with a complaint of headache in occipital area & weakness in both lower limb since 4 weeks. The patient was a diagnosed case of hypertension and was already on tablet Atenolol (25 mg) once a day. At the time of admission, the patient was found to have a pulse of 96/min and blood pressure of 170/100 mm of Hg. Power was 3/5 for both right and left lower limbs. At the time of admission, serum potassium was 2.8. As a result, the patient was shifted to tablet Metroprolol and Amlodipine (50 + 5 mg) once a day. We also added tablet Cilnidipine (10 mg) and Telmisartan (80 mg) once a day and syrup Potklor thrice a day with water. The patient was sent for renal artery doppler, urine for metanephrines and vanillylmandelic acid, serum aldosterone, plasma aldosterone/plasma renin activity ratio (PAC/PRA ratio), urinary aldosterone, urinary cortisol and adrenocorticotrophic hormone level and computed tomography (CT) abdomen to rule out hyperaldostronism. Plasma aldosterone/plasma renin activity ratio, urinary aldosterone was high and CT abdomen revealed a solitary nodule in the left adrenal gland measuring 1.2 × 1.0 cm in maximum transverse diameter, which was suggestive of adrenal adenoma. Diagnosis of Conn’s syndrome secondary to adrenal adenoma was made. The patient was advised tablet Aldactone (25 mg) once a day and serum electrolytes were repeated which showed normalization with normal blood pressure.

关键词： primary hyperaldosteronism Hypokalemia Headache Adenoma Hypertension

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