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Gut microbiome composition can predict the response to nivolumab in advanced hepatocellular carcinoma patients

World Journal of Gastroenterology 2021年第42期27卷 7340-7349页

作者： Min-Woo Chung Moon-Ju Kim Eun Jeong Won Yu Jeong Lee Yong-Woon Yun Sung Bum Cho Young-Eun Joo Jun-Eul Hwang Woo Kyun Bae Ik-Joo Chung Myung Geun Shin Jong Hee Shin Department of Internal Medicine Chonnam National University Hospital and College of MedicineHwasun 58128Jeollanam-doSouth Korea Department of Parasitology and Tropical Medicine Chonnam National University Medical SchoolHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University Hwasun HospitalHwasun 58128Jeollanam-doSouth Korea Department of Preventive Medicine Chonnam National University Medical SchoolHwasun-eupHwasun 58128Jeollanam-doSouth Korea Department of Laboratory Medicine Chonnam National University HospitalGwangju 61469South Korea

BACKGROUND Immunotherapy has revolutionized the clinical outcomes of intractable cancer *** is known about the intestinal nonpathogenic bacterial composition of hepatocellular carcinoma(HCC)patients treated by *** To determine whether there is a correlation between gut bacterial composition and prognosis in HCC *** From September 2019 to March 2020,we prospectively collected fecal samples and examined the gut microbiome of 8 advanced HCC patients treated with nivolumab as a second-or third-line systemic *** samples were collected before the start of *** samples of patients with progression during treatment were collected at the time of progression,and fecal samples of patients who showed good response to nivolumab were collected after 5-7 mo as *** data from 16S ribosomal RNA sequencing were analyzed using CLC Genomics *** data were analyzed according to therapeutic *** All 8 patients were male,of which 6 had underlying chronic hepatitis B.A higher Shannon index was found in the responders than in the non-responders after nivolumab therapy(P=0.036).The unweighted beta diversity analysis also showed that the overall bacterial community structure and phylogenetic diversity were clearly distinguished according to therapeutic *** was no significant difference in the diversity or composition of the patient gut microbiome according to the immunotherapy *** taxa specific to therapeutic response were designated as follows:Dialister pneumosintes,Escherichia coli,Lactobacillus reteri,Streptococcus mutans,Enterococcus faecium,Streptococcus gordonii,Veillonella atypica,Granulicatella sp.,and Trchuris trichiura for the nonresponders;Citrobacter freundii,Azospirillum *** Enterococcus durans for the *** note,a skewed Firmicutes/Bacteroidetes ratio and a low prevotella/bacteroides ratio can serve as predictive markers of non-response,wh

关键词： Microbiome Nivolumab Firmicutes/Bacteroidetes ratio prevotella/bacteroides ratio Hepatocellular carcinoma Prognosis

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