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Relevant detection indicator of prethrombotic state in patients with primary hypertension

世界临床病例杂志 2023年第24期11卷 5678-5691页

作者： Jie Luo Tuo Yang Lan Ding Jian-Hui Xiong Teng Ying Fen Xu Medical Technology Department Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina Inspection Department Guangdong Zhanjiang Health School Labor UnionZhanjiang 524094Guangzhou ProvinceChina Department of Medical Technology Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina Department of Cardiology The First Affiliated Hospital of Jiangxi Medical CollegeShangrao 334000Jiangxi ProvinceChina

BACKGROUND Hypertension is a common chronic disease that affects many people *** a few reports related to the exploration of relevant indicators of the prethrombotic state in patients with primary hypertension(PH)in clinical settings were *** To detect prethrombotic state-related indicators in patients with PH and analyze their differences in different patient populations to provide a laboratory basis for the clinical prevention and control of hypertensive thrombotic *** The general data of patients with PH who attended the Department of Cardiovascular Medicine,The First Affiliated Hospital of Jiangxi Medical College,from January 2022 to December 2022 were collected *** patients were divided into three groups of 40 patients each according to the Grade of PH:Grade 1,Grade 2,and Grade 3 hypertension experimental *** baseline data of 40 volunteers,who underwent physical examination in our hospital but were not diagnosed with PH during the same period,were included in the control *** relevant indicators of prethrombotic state of the participants were compared,and mainly included inflammation-related indicators,hemorheology-related indicators,and coagulation function related *** relationship between the aforementioned indicators and the progression of PH was *** No significant differences were observed in age,sex,diabetes mellitus,smoking history,drinking history,body mass index,New York Heart Association functional classification,or the course of hypertension among the four groups(P>0.05).The expressions of high-sensitivity C-reactive protein(hs-CRP),thrombomodulin(TM),hematocrit(Hct),erythrocyte sedimentation rate(ESR),P-selectin on platelet surface(CD62P),and fibrinogen(FIB)in the control group were

关键词： Primary hypertension prethrombotic state Hematocrit P-selectin on platelet surface Activated partial thromboplastin time Erythrocyte sedimentation rate

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Study of patients with OSAS in prethrombotic state

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中国医药导报 2007年第1X期4卷 17-19页

作者： PAN Lei XU Wenbing .Department of Pulmonary Medicine Peking Union Medical College HospitalBeijing 100730China Peking Union Medical College Hospital Chinese Academy of Medical SciencesBeijing 100730China

Objective:To investigate the molecular markers change of prethrombotic state in patients with obstructive sleep apnea syndrome (OSAS) and estimate the effects of nasal continuous positive airway pressure (nCPAP) therapy. Methods:To perform case-controlled study in 30 patients with OSAS and 30 healthy control group. The patients with OSAS were diagnosed by the polysomnography monitor system and treated by Auto-CPAP. Blood samples were taken and measured GMP-140, APTT, AT-Ⅲ,PAI and t-PA. Results: As compared with the normal controls, the level of GMP-140 which reflects platelet activation was increased in patients with OSAS[(29.67±8.68)% vs (3.07±1.74)%, Pprethrombotic state is present in patients with OSAS, nCPAP theraphy can correct nocturnal hypoxaemia, partly or totally reverse prethrombotic state of patients with OSAS, decrease OSAS-related thrombotic complications.

关键词： OSAS prethrombotic state nCPAP

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Meta-Analysis of Bushen Huoxue Method in the Treatment of Recurrent Spontaneous Abortion Due to prethrombotic state

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Journal of Clinical and Nursing Research 2022年第2期6卷 163-172页

作者： Rong-Feng Pu Nan Li Hong-Li Zhu Jun Bai Mei Chen Shaanxi University of Chinese Medicine Xianyang 712000China Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712000China

Objective:To evaluate the effectiveness and safety of Bushen Huoxue prescription in the treatment of recurrent spontaneous abortion(RSA)due to prethrombotic state(PTS).Methods:Databases such as CNKI,WanFang,VIP,CBM,PubMed,Embase,and Cochrane Library were searched for randomized controlled trials on Bushen Huoxue prescription in treating RSA due to PTS from inception to March 2021;meta-analysis was performed by RevMan Version 5.3.0 following quality ***:Seven trials were included,with 496 patients;the meta-analysis indicated that Bushen Huoxue prescription has advantages on the improvement of total clinical effective rate[RR=1.22,95%CI(1.10,1.35),Z=3.80(P=0.0001)],embryo survival rate at pregnancy of 12 weeks[RR=1.25,95%CI(1.10,1.41),Z=3.53(P=0.0004)],D-dimer levels[SMD=-1.59,95%CI(-2.20,-0.97),Z=5.07(Pprethrombotic state.

关键词： Bushen Huoxue method Recurrent spontaneous abortion prethrombotic state Systematic review Meta-analysis

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