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Determination of full-scale pore size distribution of Gaomiaozi bentonite and its permeability prediction

Journal of Rock Mechanics and Geotechnical Engineering 2020年第2期12卷 403-413页

作者： Jiangfeng Liu Shuaibing Song Xulou Cao Qingbin Meng Hai Pu Yangguang Wang Jianfeng Liu State Key Laboratory for Geomechanics and Deep Underground Engineering School of Mechanics and Civil EngineeringChina University of Mining and TechnologyXuzhou221116China Key Laboratory of Deep Earth Science and Engineering Ministry of EducationSichuan UniversityChengdu610065China

Gaomiaozi(GMZ)bentonite is a potential buffer/backfill material for a deep geological disposal of highlevel radioactive waste.It has a wide pore size distribution(PSD)with sizes ranging from several nanometers to more than one hundred microns.Thus,properly characterizing the pore structures of GMZ bentonite is a challenging issue.In this study,pressure-controlled porosimetry(PCP),ratecontrolled porosimetry(RCP),and scanning electron microscopy(SEM)were used to investigate the PSD of GMZ bentonite,The results indicate that each method has its limitation,and a combined use of PCP and RCP is suitable to obtain the full-scale PSD of GMZ bentonite.Moreover,we also compared the full-scale PSD with nuclear magnetic resonance(NMR)result.It is found that there is no significant difference in the range of PSD characterization between NMR and mercury intrusion method(PCP and RCP).However,in a ce rtain range,the detection accuracy of NMR is higher than that of mercury injection method.Finally,permeability prediction based on PCP and SEM data was conducted,and both of the two methods were found to be able to predict the permeability.The combined method is effective to obtain the full-scale PSD of GMZ bentonite,which is the key to estimation of the sealing ability of bentonite buffer.

关键词： Gaomiaozi(GMZ)bentonite Pore size distribution(PSD) pressure-controlled porosimetry(PCP) Rate-controlled porosimetry(RCP) Permeability High-level radioactive waste

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Contemporary perspective on endogenous myocardial regeneration

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World Journal of Stem Cells 2015年第5期7卷 793-805页

作者： Dejan Milasinovic Werner Mohl Department of Cardiology Clinical Centre of Serbia Department of Cardiac Surgery Medical University of Vienna

Considering the complex nature of the adult heart, it is no wonder that innate regenerative processes, while maintaining adequate cardiac function, fall short in myocardial jeopardy. In spite of these enchaininglimitations, cardiac rejuvenation occurs as well as restricted regeneration. In this review, the background as well as potential mechanisms of endogenous myocardial regeneration are summarized. We present and analyze the available evidence in three subsequent steps. First, we examine the experimental research data that provide insights into the mechanisms and origins of the replicating cardiac myocytes, including cell populations referred to as cardiac progenitor cells(i.e., c-kit+ cells). Second, we describe the role of clinical settings such as acute or chronic myocardial ischemia, as initiators of pathways of endogenous myocardial regeneration. Third, the hitherto conducted clinical studies that examined different approaches of initiating endogenous myocardial regeneration in failing human hearts are analyzed. In conclusion, we present the evidence in support of the notion that regaining cardiac function beyond cellular replacement of dysfunctional myocardium via initiation of innate regenerative pathways could create a new perspective and a paradigm change in heart failure therapeutics. Reinitiating cardiac morphogenesis by reintroducing developmental pathways in the adult failing heart might provide a feasible way of tissue regeneration. Based on our hypothesis "embryonic recall", we present first supporting evidence on regenerative impulses in the myocardium, as induced by developmental processes.

关键词： Cardiac regeneration Cardiac development Embryonic recall pressure-controlled intermittentcoronary sinus occlusion Heart failure Myocardialinfarction

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