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prenatal risk factors for internalizing and externalizing problems in childhood

World Journal of Pediatrics 2020年第4期16卷 341-355页

作者： Joyce Tien Gary D.Lewis Jianghong Liu Department of Family and Community Health School of NursingUniversity of PennsylvaniaPhiladelphiaPA19104USA University of Arkansas for Medical Sciences Little RockARUSA

Background A growing body of research has documented the effects of prenatal risk factors on a wide spectrum of adverse offspring health *** behavior problems,such as externalizing and internalizing problems,are no *** comprehensive literature review aims to summarize and synthesize current research about commonly experienced prenatal risk factors associated with internalizing and externalizing problems,with a focus on their impact during childhood and *** mechanisms as well as implications are also *** sources The EBSCO,Web of Science,PubMed,Google Scholar,and Scopus databases were searched for studies examining the association between prenatal risk factors and offspring internalizing/externalizing problems,using keywords“prenatal”or“perinatal”or“birth complications”in combination with“internalizing”or“externalizing”.Relevant articles,including experimental research,systematic reviews,meta-analyses,cross-sectional and longitudinal cohort studies,and theoretical literature,were reviewed and synthesized to form the basis of this integrative *** prenatal risk factors that have been widely investigated with regards to offspring internalizing and externalizing problems encompass health-related risk factors,including maternal overweight/obesity,substance use/abuse,environmental toxicant exposure,maternal infection/inflammation,as well as psychosocial risk factors,including intimate partner violence,and anxiety/***,both epidemiological and experimental studies support the adverse associations between these prenatal factors and increased risk of emotional/behavioral problem development during childhood and *** mechanisms of action underlying these associations include hormonal and immune system *** include prenatal education,screening,and intervention *** prenatal risk factors are associated with a constellation of offspring internalizin

关键词： Externalizing Internalizing Obstetrical Pregnancy prenatal risk factors

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