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The interaction effect between advanced paternal age and paternal obesity is associated with the low implantation rate in couples with unexplained recurrent pregnancy loss

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Gynecology and Obstetrics Clinical Medicine 2021年第4期1卷 197-204页

作者： Shuo Li Yaqian Shen Yueting Zhu Hongchang Li Wenjie Jiang Junhao Yan Zi-Jiang Chen Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinanShandong250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong UniversityJinanShandong250012China Shandong Key Laboratory of Reproductive Medicine JinanShandong250012China Shandong Provincial Clinical Research Center for Reproductive Health JinanShandong250012China National Research Center for Assisted Reproductive Technology and Reproductive genetics Shandong UniversityJinanShandong250012China Shanghai Key Laboratory for Assisted Reproduction and Reproductive genetics Shanghai200135China Center for Reproductive Medicine Ren Ji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200135China

Objective:To explore the roles of advanced paternal age(APA)and abnormal paternal weight on embryo quality and pregnancy outcomes for unexplained recurrent pregnancy loss(uRPL)couples who underwent preimplantation genetic testing for aneuploidies(PGT-A).Methods:This study included 779 uRPL couples who underwent their first PGT-A cycles between 2014 and *** patients’aging and nutritional status were quantified by paternal age and body mass index(BMI).Routine semen parameters and sperm DNA fragmentation index(DFI)were used to reflect the seminal *** formation rate and aneuploidy rate were used to reflect the embryo *** cancellation rate,implantation rate,pregnancy loss rate,and live birth rate were measured to evaluate the treatment efficiency from *** remove the interference of maternal age,only the women younger than 38 years old were *** univariate screening,interaction tests were performed in a generalized linear model(GLM)to further examine the effects of paternal age and BMI on each outcome ***:In the total population(779 cycles),there were no statistical differences in aneuploidy rate,cycle cancellation rate,implantation rate,pregnancy loss rate,and live birth rate,whether stratified by paternal age or paternal *** results occurred in the younger men(testing,the results of GLM suggested that the interaction effect between APA and paternal obesity was associated with the low implantation rate of uRPL ***:For the uRPL couples seeking for PGT-A treatment,if the male patients have both advanced age and obesity,their spouses are at higher risks for embryo implantation failure

关键词： Advanced paternal age Implantation rate Live birth rate Obesity preimplantation genetic test Unexplained recurrent pregnancy loss

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