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Review:Mitochondrial functions on oocytes and preimplantation embryos

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第7期10卷 483-492页

作者： Li-ya WANG Da-hui WANG Xiang-yang ZOU Chen-ming XU Department of Biotechnology Dalian Medical University Dalian 116044 China The Sperm Laboratory Institute of Cell Biology and Genetics College of Life Sciences Zhejiang University Hangzhou 310058 China Department of Reproductive Endocrinology Women's Hospital School of Medicine Zhejiang University Hangzhou 310006 China

Oocyte quality has long been considered as a main limiting factor for in vitro fertilization （IVF）. In the past decade, extensive observations demonstrated that the mitochondrion plays a vital role in the oocyte cytoplasm, for it can provide adenosine triphosphate （ATP） for fertilization and preimplantation embryo development and also act as stores of intracellular calcium and proapoptotic factors. During the oocyte maturation, mitochondria are characterized by distinct changes of their distribution pattern from being homogeneous to heterogeneous, which is correlated with the cumulus apoptosis. Oocyte quality decreases with the increasing maternal age. Recent studies have shown that low quality oocytes have some age-related dysfunctions, which include the decrease in mitochondrial membrane potential, increase of mitochondrial DNA （mtDNA） damages, chromosomal aneuploidies, the incidence of apoptosis, and changes in mitochoncLrial gene expression. All these dysfunctions may cause a high level of de- velopmental retardation and arrest of preimplantation embryos. It has been suggested that these mitochondrial changes may arise from excessive reactive oxygen species （ROS） that is closely associated with the oxidative energy production or calcium overload, which may trigger permeability transition pore opening and subsequent apoptosis. Therefore, mitochondria can be seen as signs for oocyte quality evaluation, and it is possible that the oocyte quality can be improved by enhancing the physical function of mitochondria. Here we reviewed recent advances in mitochondrial functions on oocytes.

关键词： Mitochondria Oocyte preimplantation embryo

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Aurora Kinase B and C have Distinct Functions of in Mouse Oocytes and preimplantation embryos.

Aurora Kinase B and C have Distinct Functions of in Mouse Oo...

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“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Wenzhi Li,Jie Na School of Medicine,Tsinghua University,Beijing,China

During mammalian oocyte meiosis and preimplantation development,abnormal cell division happens frequently and can lead to serious defect in the *** kineses are evolutionarily conserved serine/threonine kinase playing important roles during cell *** found that the mammalian germ cell specific Aurora kinase C is highly expressed in mouse oocyes and preimplantation *** siRNA and specific chemical inhibitor,we investigate the function of Aurora C and its close homologue, Aurora B,in these ***,knocking down Aurora B or C differentially affected securin degradation and the timing of cell division,while their overexpression had the opposite *** C knocking down delayed the timing of homologous separation,and this can not be rescued by Aurora B overexpression,suggesting that they have distinct roles in spindle assembly checkpoint(SAC). Moreover,dominant negative MAD1 were also unable to override the SAC activation caused by knocking down Aurora C,implying that it is down stream of MAD2 and a critical component of *** results indicate that the balance between Aurora B and Aurora C may regulate the timing of cell division in mouse oocytes and preimplantation embryos.

关键词： aurora kinase mouse oocyte preimplantation embryo

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Molecules and mechanisms controlling the active DNA demethylation of the mammalian zygotic genome

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Protein & Cell 2014年第11期5卷 827-836页

作者： Jun-Yu Ma Teng Zhang Wei Shen Heide Schatten Qing Yuan Sun College of Animal Science and Technology Qingdao Agricultural University Qingdao 266109 China State Key Laboratory of Reproductive Biology Institute of Zoology Chinese Academy of Sciences Beijing 100101 China Department of Veterinary Pathobiology University of Missouri Columbia MO 65211 USA

The active DNA demethylation in early embryos is essential for subsequent development. Although the zygotic genome is globally demethylated, the DNA methylation of imprinted regions, part of repeat sequences and some gamete-specific regions are maintained. Recent evidence has shown that multiple proteins and biological pathways participate in the regulation of active DNA demethylation, such as TET proteins, DNA repair pathways and DNA methyltransferases. Here we review the recent understanding regarding proteins associated with active DNA demethylation and the regulatory networks controlling the active DNA demethylation in early embryos.

关键词： active DNA demethylation zygote 5-hmC5-mC preimplantation embryo TET proteins

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Insulin-like Growth Factor-I (IGF-I) in Reproduction System of Female Bovine

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Journal of Northeast Agricultural University(English Edition) 2011年第4期18卷 84-87页

作者： QI Meiyu ZviRoth LIU Di College of Animal Sciences and Technology Northeast Agricultural University Harbin 150030 China Institute of Animal Husbandry Heilongjiang Academy of Agricultural Sciences Harbin 150086 China Department of Animal Sciences Faculty of Agriculture Food and Environmental Quality Sciences Hebrew University of Jerusalem Rehovot 76100 Israel

Insulin-like growth factor-I （IGF-I） plays a key role in female reproduction, because it has the effect of anti-apoptosis improving cell proliferation, transformation and differentiation. This paper reviewed the effects of IGF-I on ovary, follicle growth, acquisition of oocyte competence and preimplantation embryo viability, and then summarized different points about IGF-1 for reproduction system

关键词： IGF-1 bovine reproduction system ovary follicle oocyte preimplantation embryo

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