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Berberine-Promoted CXCR4 Expression Accelerates Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Persons with prehypertension

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Chinese Journal of Integrative Medicine 2018年第12期24卷 897-904页

作者： SHAO Yi-jia TAO Jun YU Bing-bo MENG Dan YANG Xu-long SUN Jia-pan QIU Yan-xia ZHANG Xiao-yu Department of Hypertension and Vascular Disease the First Affiliated Hospital of Sun Yat-Sen UniversityKey Laboratory on Assisted CirculationMinistry of HealthGuangzhou 510080China

Objective： To evaluate whether the berberine treatment can improve endothelial repair capacity of early endothelial progenitor cells （EPCs） from prehypertensive subjects through increasing CXC chemokine receptor 4 （CXCR4） signaling. Methods： EPCs were isolated from prehypertensive and healthy subjects and cultured. In vivo reendothelialization capacity of EPCs from prehypertensive patients with or without in vitro berberine treatment was examined in a nude mouse model of carotid artery injury. The protein expressions of CXCR4/Janus kinase-2 （JAK-2） signaling of in vitro EPCs were detected by Western blot analysis. Results： CXCR4 signaling and alteration in migration and adhesion functions of EPCs were evaluated. Basal CXCR4 expression was significantly reduced in EPCs from prehypertensive patients compared with normal subjects （P〈0.01）. Also, the phosphorylation of JAK-2 of EPCs, a CXCR4 downstream signaling, was significantly decreased （P〈0.01）. Berberine promoted CXCR4/JAK-2 signaling expression of in vitro EPCs （P〈0.01）. Transplantation of EPCs pretreated with berberine markedly accelerated in vivo reendothelialization （P〈0.01）. The increased in vitro function and in vivo reendothelialization capacity of EPCs were inhibited by CXCR4 neutralizing antibody or pretreatment with JAK-2 inhibitor AG490, respectively （P〈0.01）. Conclusion： Berberine- modified EPCs via up-regulation of CXCR4 signaling contributes to enhanced endothelial repair capacity in prehypertension, indicating that berberine may be used as a novel potential primary prevention means against prehypertension-related atherosclerotic cardiovascular disease.

关键词： prehypertension berberine endothelial progenitor cells reendothelialization CXC chemokine receptor 4

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Risk factors for prehypertension in Xinjiang Uygur population

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Journal of Geriatric Cardiology 2010年第2期7卷 97-100页

作者： Lei Wang Nan-Fang Li Jin Yang Ling Zhou Tao Li Jing Hong Center for Diagnosis Treatment and Research of Hypertension in XinjiangUrumqiXinjiang830000China

Objective To assess the risk factors for prehypertension in Xinjiang Uygur population. Methods A cross-section study was conducted in a Xinjiang Uygur population（438 males and 716 females,aged 30 to 70 years）.The fasting lipid profiles,serum glucose,insulin,and uric acid were *** model assessment of insulin resistance（HOMA-IR）index was used to assess insulin resistance（IR）.Binary logistic regression analysis was performed to determine risk factors for *** pressure levels ofnormotensives and prehypertensives in different body mass index（BMI）categories were compared. Results Binary logistic regression analysis performed after adjustment for gender,lipids profiles,waist-to-hip ratio,uric acid,HOMA-IR,and lifestyle（alcohol drinking and smoking）showed a significantly increasing prevalence of prehypertension with *** odds ratios for prehypertension against the lowest BMI group（separated by 24 and 28）were 1.934 and 2.490（95% confidence interval：1.435-2.606 and 1.825-3.399,respectively）.Age was independently correlated to the increasing prevalence of ***-IR was not associated with *** mean diastolic blood pressure（DBP）was significantly increased with BMI categories in either normotensives or prehypertensives（P〈0.001）while the mean systolic blood pressure（SBP）was significantly increased with BMI only in normotensives（P〈0.001）. Conclusions In Xinjiang Uygurs,BMI and age was the risk factors for *** is significantly increased with *** is not associated with *** findings emphasize the importance of management of obesity for the control of blood pressure and other cardiovascular complications.

关键词： prehypertension body mass index Uygur.

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Prevalence of hypertension and prehypertension in Nepal:a systematic review and meta-analysis

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Global Health Research and Policy 2019年第1期4卷 293-302页

作者： Yun Huang Pi Guo Biraj M.Karmacharya Sharvesh Raj Seeruttun Dong Roman Xu Yuantao Hao Department of Medical Statistics and Epidemiology School of Public HealthSun Yat-sen UniversityNo.74 Zhongshan Road IIGuangzhou 510080Guangdong ProvincePeople’s Republic of China Department of Preventive Medicine Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Sun Yat-sen Global Health Institute(SGHI) School of Public Health and Institute of National Governance of Sun Yat-sen UniversityGuangzhou 510275Guangdong ProvinceChina Department of Gastric Surgery Sun Yat-sen University Cancer CenterState Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer MedicineGuangzhou 510060Guangdong ProvinceChina

Background:Studies regarding blood pressure of Nepal have demonstrated a contrasting *** aimed at providing a generalized estimate of the prevalence of hypertension and prehypertension in urban,suburban,and rural areas of ***:This systematic review followed PRISMA guidelines.A thorough search of PubMed,EMBASE,and Web of Science was performed,and studies satisfying the eligibility criteria were *** prevalence was calculated by random-effects model,and the sources of heterogeneity were explored with meta-regression and subgroup ***:Twenty-three studies with 99,792 subjects were identified,and the estimated rate of hypertension and prehypertension were found to be 27.3%(95%CI:23.8-30.9)and 35.4%(30.3-40.8).The prevalence of hypertension was 28.4%(22.4-34.7),25.5%(21.4-29.8),and 24.4%(17.9-31.6)among urban,suburban,and rural populations,***,rates of hypertension were found to be substantially higher in male(31.6%,27.3-36.1)compared to female(20.0%,14.2-26.6),and significantly higher among the middle-aged(≥40 years;36.8%,29.4-44.5)than among younger adults(prehypertension prevalence was found to be highest in rural areas(40.4%,25.4-56.4)followed by urban areas(29.3%,20.8-38.5)and lowest in suburban areas(25.5%,18.9-32.7).Conclusions:Our study identified an alarming situation of hypertension among Nepalese males and middle-aged,and a situation of concern with prehypertension in rural areas affecting almost 40%of the population.

关键词： Hypertension prehypertension Prevalence Nepal Systematic review Meta-analysis

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prehypertension, Hypertension and Associated Cardiovascular Risk Factors among Adult Congolese Urban Dwellers: Results of the Vitaraa Study

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World Journal of Cardiovascular Diseases 2014年第8期4卷 390-398页

作者： Mwasa Pascal Bayauli Jean-Rene M’Buyamba-Kayamba Daniel Lemogoum Robert Fagard Jean Paul Degaute Mpandamadi Symphorien Ditu Bompeka Francois Lepira Jean-Rene M’Buyamba-Kabangu Hypertension Unit/Cardiology Department of Internal MedicineUniversity of Kinshasa HospitalKinshasaThe Democratic Republic of the Congo Division of Endocrinology and Nuclear Medicine Department of Internal MedicineUniversity of Kinshasa HospitalKinshasaThe Democratic Republic of the Congo Erasmus Hospital Brussels Free UniversityBrusselsBelgium Division of Hypertension and Cardiovascular Rehabilitation University of LeuvenLeuvenBelgium Division of Nephrology Department of Internal MedicineUniversity of Kinshasa HospitalKinshasaThe Democratic Republic of the Congo

Objective: To assess the prevalence of prehypertension and hypertension, their determinants and associated cardiovascular risk factors in Congolese urban dwellers. Methods: From July 2007 to March 2008, we collected information on lifestyle habits, medical history and anthropometric data in 1292 household members of Adoula Quarter, Kinshasa, aged 20 years or more, 731 women (56.6%). We obtained measurements of BP, blood glucose, serum lipids and qualitative proteinuria. We defined blood pressure categories according to JNC7 classification and used logistic regression analyses to assess their independent determinants. We obtained age adjustment of continuous and categorical variables using GLM and Genmod procedures, respectively. Results: prehypertension was observed in 30.3% of subjects, 34.9% of men and 26.7% of women (P = 0.0045). The prevalence of hypertension amounted to 30.9% with no difference between genders. Participants with prehypertension had average age, BMI and waist circumference intermediate between those with normal BP and hypertensive subjects. Their glucose and lipids levels were similar to those of normotensives. The prevalence of prehypertension amounted to 33% at age 20 - 29 years and decreased to 16.7% at ≥60 years whereas the prevalence of hypertension increased from 11.2% to 71.4%. The rates of diabetes mellitus were similar accross blood pressure catogo- ries whilst prevalences of overweight/obesity, abdominal adiposity, dyslipidemia and metabolic syndrome significatively increased (P = 0.05 or less). Among participants with prehypertension, 73% had two or more additional cardiovascular risk factors. In the logistic model the probability of prehypertension was higher in men (OR: 1.429;95% CI: 1.099 - 1.857) and participants with overweight/obesity (OR: 1.666;1.146 - 2.422), lower in participants aged ≥ 55 years (0.427;0.267 - 0.683) and those with high fruit intake (0.691;0.488 - 0.977). The probability of hypertension was higher in particip

关键词： prehypertension Hypertension Cardiovascular Risk Factors Africans

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prehypertension: Underlying pathology and therapeutic options

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World Journal of Cardiology 2014年第8期6卷 728-743页

作者： Sulayma Albarwani Sultan Al-Siyabi Musbah O Tanira Department of Physiology College of Medicine and Health SciencesSultan Qaboos UniversityMuscat 123Oman Department of Pharmacology and Clinical Pharmacy College of Medicine and Health SciencesSultan Qaboos UniversityMuscat 123Oman

prehypertension(PHTN) is a global major health risk that subjects individuals to double the risk of cardiovascular disease(CVD) independent of progression to overt hypertension. Its prevalence rate varies considerably from country to country ranging between 21.9% and 52%. Many hypotheses are proposed to explain the underlying pathophysiology of PHTN. The most notable of these implicate the renin-angiotensin system(RAS) and vascular endothelium. However, other processes that involve reactive oxygen species, the inflammatory cytokines, prostglandins and C-reactive protein as well as the autonomic and central nervous systems are also suggested. Drugs affecting RAS have been shown to produce beneficial effects in prehypertensives though such was not unequivocal. On the other hand, drugs such as β-adrenoceptor blocking agents were not shown to be useful. Leading clinical guidelines suggest using dietary and lifestyle modifications as a first line interventional strategy to curb the progress of PHTN; however, other clinically respected views call for using drugs. This review provides an overview of the poten-tial pathophysiological processes associated with PHTN, abridges current intervention strategies and suggests investigating the value of using the "Polypill" in prehypertensive subjects to ascertain its potential in delaying(or preventing) CVD associated with raised blood pressure in the presence of other risk factors.

关键词： prehypertension Renin-angiotensin system Therapeutic lifestyle changes Polypill

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Severity of non-alcoholic fatty liver disease is a risk factor for developing hypertension from prehypertension

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Chinese Medical Journal 2023年第13期136卷 1591-1597页

作者： Qirui Song Qianhui Ling Luyun Fan Yue Deng Qiannan Gao Ruixue Yang Shuohua Chen Shouling Wu Jun Cai Hypertension Center Fuwai HospitalState Key Laboratory of Cardiovascular Disease of ChinaNational Center for Cardiovascular Diseases of ChinaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China State Key Laboratory of Cardiovascular Disease of China Fuwai HospitalNational Center for Cardiovascular Diseases of ChinaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China Department of Cardiology Kailuan General HospitalTangshanHebei 063000China

Background:There is little published evidence about the role of non-alcoholic fatty liver disease(NAFLD)in the progression from prehypertension to *** study was conducted to investigate the association of NAFLD and its severity with the risk of hypertension developing from ***:The study cohort comprised 25,433 participants from the Kailuan study with prehypertension at baseline;those with excessive alcohol consumption and other liver diseases were *** was diagnosed by ultrasonography and stratified as mild,moderate,or *** and multivariable Cox proportional hazard regression was used to calculate the hazard ratios(HRs)and 95%confidence intervals(CIs)of incident hypertension according to the presence and 3 categories of severity of ***:During a median of 12.6 years of follow-up,10,638 participants progressed to hypertension from *** adjusting for multiple risk factors,patients with prehypertension and NAFLD had a 15%higher risk of incident hypertension than those without NAFLD(HR=1.15,95%CI 1.10-1.21).Moreover,the severity of NAFLD was associated with the incidence of hypertension,which was higher in patients with more severe NAFLD(HR=1.15[95%CI 1.10-1.21]in the mild NAFLD group;HR=1.15[95%CI 1.07-1.24]in the moderate NAFLD group;and HR=1.20[95%CI 1.03-1.41]in the severe NAFLD group).Subgroup analysis indicated that age and baseline systolic blood pressure may modify this ***:NAFLD is an independent risk factor for hypertension in patients with *** risk of incident hypertension increases with the severity of NAFLD.

关键词： Hypertension Non-alcoholic fatty liver disease prehypertension

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Combined action of C-reactive protein and lipid profiles on risk of hypertension and prehypertension in Mongolian adults in Inner Mongolia, China

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Chinese Medical Journal 2014年第11期127卷 2016-2020页

作者： Zhang Shihui Xu Tian Peng Yanbo Peng Hao Wang Aili Wang Guiyan Wang Dali Zhang Yonghong Department of Epidemiology School of Public Health Medical College of Soochow University Suzhou Jiangsu 215123 China Department of Food Sanitation Suzhou Food and Drug Administration Suzhou Jiangsu 215007 China Department of Neurology Affiliated Hospital of Hebei United UniversityTangshan Hebei 063000 China Department of Health Care Xiamen Maternal and Child Care Hospital Xiamen Fujian 361003 China

Background Many studies have suggested that C-reactive protein （CRP） and blood lipids are associated with hypertension and cardiovascular disease （CVD）.However,few studies discussed the combined action of CRP and blood lipids on the risk of hypertension and *** study aimed to investigate the combined action of CRP and lipid profiles on the risk of hypertension and prehypertension in Mongolian adults from Inner Mongolia,*** The systolic and diastolic blood pressure,height,weight and waist circumference were measured and factors such as smoking,alcohol intake,family history of hypertension,etc.,were investigated and CRP,low-density lipoprotein cholesterol （LDL-C）,triglycerides （TG） were tested for 2 534 Mongolian adults aged ≥20 *** subjects were divided into four subgroups,namely CRP 〈median and LDL-C （TG）〈median subgroup,CRP 〈median and LDL-C （TG）〉median subgroup,CRP 〉median and LDL-C （TG）〈median subgroup and CRP 〉median and LDL-C （TG）〉median *** ORs （95% C/s） of hypertension and prehypertension for the subgroups were calculated by univariate and multivariate *** The multivariate adjusted ORs （95%CIs） of hypertension/prehypertension were 1.389 （0.979-1.970）/1.1 51（0.865-1.531）,1.666 （1.159-2.394）/1.431 （1.060-1.930）,1.756 （1.242-2.484）/ 1.770 （1.321-2.372）,for CRP 〈median and LDL-C 〉median subgroup,CRP 〉median and LDL-C 〈median subgroup,and CRP 〉median and LDL-C 〉median subgroup,respectively,compared with CRP 〈median and LDL-C 〈median ***,the multivariate adjusted ORs （95% CIs） of hypertension/prehypertension were 2.032 （1.394-2.963）/1.442 （1.047-1.988）,1.412 （0.960-2.079）/1.596 （1.166-2.184）,and 2.197 （1.595-3.027）/1.730 （1.321-2.266） for CRP 〈median and TG 〉median subgroup,CRP 〉median and TG 〈median subgroup,and CRP 〉median and TG 〉median subgroup,respectively,compared with CRP 〈median and TG 〈median *** risks of hypertension and prehypertension were the highest in the CRP 〉median a

关键词： hypertension prehypertension C-reactive protein blood lipid

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Prevalence and Risk Factors Associated with prehypertension among Young and Middle-Aged Health Check-Up Population in Guangzhou

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Journal of Advances in Medicine Science 2021年第1期4卷 1-11页

作者： Lulu Yan Xia Lu Yao Zhong Man Lin Fangfang Lu Rui Wang Tianhui You School of Nursing Guangdong Pharmaceutical UniversityGuangzhouGuangdong510000China Department of Epidemiology and Biostatistics School of Public HealthGuangdong Pharmaceutical UniversityGuangzhouGuangdong510000China

Objective:To provide basic information and theories for prehypertension early intervention,a systematic analysis of the epidemic status and risk factors among young and middle-aged was carried out ***:This study relied on the data bank of a health check-up population of a class a tertiary general hospital in Guangdong province in *** 9540 young and middle-aged adults were enrolled,and 733 people were included to find out the effect with lifestyle in these *** Components Analysis(PCA)of Factor(FA)was used to identify dietary *** logistic regression model was used to find the risk factors of ***:Among 9540 young and middle-aged cases,the incidence of prehypertension was 36.6%.Moreover,the average age,proportion of male gender,overweight,FBG(fasting blood glucose),dyslipidemia,and hyperuricemia were significantly higher in the prehypertension group than in the optimal BP *** logistic regression analysis indicated that age,total cholesterol,triglycerides,uric acid,body mass index and HR(heart rate)were risk factors,and female was a protective factor for *** 733 cases,the incidence of prehypertension was 35.1%.The proportion of smoking,drinking,physical workers,moderate and severe physical activity,and the intake of meat,dietary energy were significantly higher in the prehypertension group than in the optimal BP *** patterns included“meat model”,“spice model”,“main vegeTables model”and“high protein model”.Multivariate logistic regression analysis indicated that age,drinking were risk factors for prehypertension,while dietary milk intake,dietary magnesium intake were protective ***:prehypertension is highly prevalent in ***,education about effective lifestyle modifications as an alcohol limit,increasing the intake of dairy products,and magnesium may intervene in the development of *** how to develop targeted interventions for su

关键词： prehypertension Health examination Healthy lifestyle characteristics Dietary patterns Nutrition Risk factors

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我对prehypertension的思考

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中国医刊 2003年第12期38卷 59-59页

作者：胡大一北京大学人民医院

美国关于高血压预防、检测、评估和治疗的全国联合委员会的第七次报告(JNC-7)中首次提出将收缩压120～139mmHg或舒张压80～89mmHg列为prehypertension[1],在国内多译为'高血压前期',我建议译为'高血压前状态'更合适.

关键词： prehypertension 收缩压高血压预防血压异常危险因素

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Association of resting heart rate and hypertension stages on all-cause and car- diovascular mortality among elderly Koreans： the Kangwha Cohort Study

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Journal of Geriatric Cardiology 2016年第7期13卷 573-579页

作者： Mikyung Ryu Gombojav Bayasgalan Heejin Kimm Chung Mo Nam Heechoul Ohrr Institute on Aging Ajou University Medical Center Suwon South Korea College of Physical Education Kyonggi University Suwon South Korea Department of Public Health the Graduate School Yonsei University Seoul South Korea Department of Epidemiology and Health Promotion Institute for Health Promotion Graduate School of Public Health Yonsei University Seoul South Korea Department of Preventive Medicine Yonsei University College of Medicine Seoul South Korea

Background Elevated resting heart rate and hypertension independently increase the risk of mortality. However, their combined ef- fect on mortality in stages of hypertension according to updated clinical guidelines among dderly population is unclear. Methods We fol- lowed a cohort of 6100 residents （2600 males and 3500 females） of Kangwha County, Korea, ranging from 55 to 99 year-olds as of March 1985, for all-cause and cardiovascular mortality for 20.8 years until December 31, 2005. Mortality data were collected through telephone calls and visits （to 1991）, and were confirmed by death record matching with the National Statistical Office （1992-2005）. Hazard ratios were calculated for all-cause and cardiovascular mortality by resting heart rate and hypertension defined by Eighth Joint National Committee crite- ria using the Cox proportional hazard model after controlling for confounding factors. Results The hazard ratios associated with resting heart rate 〉 80 beats/min were higher in hypertensive men compared with normotensives with heart rate of 61-79 beats/rain, with hazard ratios values of 1.43 （95% CI： 1.00-1.92） on all-cause mortality for prehypertension, 3.01 （95% CI： 1.07-8.28） on cardiovascular mortality for prehypertension, and 8.34 （95% CI： 2.52-28.19） for stage 2 hypertension. Increased risk （HR： 3.54, 95% CI： 1.16-9.21） was observed among those with both a resting heart rate 〉 80 beats/rain and prehypertension on cardiovascular mortality in women. Conclusions Indi- viduals with coexisting elevated resting heart rate and hypertension, even in prehypertension, have a greater risk for all-cause and cardiovas- cular mortality compared to those with elevated resting heart rate or hypertension alone. These findings suggest that elevated resting heart rate should not be regarded as a less serious risk factor in elderly hypertensive patients.

关键词： Cardiovascular diseases Heart rate Hypertension Mortality prehypertension

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