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中国营养学会第十五届全国营养科学大会

作者： Wenfei Pan He Gao Xiaoling Ying Jili Chen Feiyan Wu Sasa Xie Min Yang Department of Nutrition and food hygiene School of Public Health and Center of Clinical Big Data and Analytics of The Second Affiliated Hospital Zhejiang University School of Medicine Linping Campus The Second Affiliated Hospital of Zhejiang University School of Medicine

Iron deficiency anemia(IDA) is a serious publichealth problem worldwide, and traditional iron supplements such as ferroussulfate have many adverse effects. This study was to systematically evaluatethe effects of dietary oligopeptide(iron chelate) supplementation on IDApregnant rats and offspring, and to provide a basis for the development of new dietaryoligopeptide(iron chelate) supplements. Methods The IDA model was established using SPF Sprague Dawley(SD) female rats fed with low iron diet and divided into seven groups(6-9 rats per group) according to hemoglobin(Hb) and body weight: IDA model group atiron dose of 4 ppm(ID), high dose of ferrous sulfate group at iron dose of 400 ppm(H-FeSO4),low dose of ferrous sulfate group at iron dose of 40 ppm(L-FeSO4),marine fish oligopeptide chelated iron group at iron dose of 400 ppm(MCOP-Fe),marine fish oligopeptide group at iron dose of 40 ppm(MOP), whey proteinoligopeptide chelated iron group at iron dose of 400 ppm(WPPFe) and wheyprotein oligopeptide group at iron dose of 40 ppm(WPOP). rats in each groupwere fed with the corresponding special diet during pregnancy until the day ofdelivery. Hemoglobin(Hb), ironmetabolism, liver oxidative stress, tumor necrosis factor α(TNF-α) and development of offspring were investigated. Results 1) After iron supplementation, the Hb of IDA pregnant rats in all interventiongroups was higher than that of the ID group(all P<0.05), and the MCOP-Fe and WPP-Fe groups had more advantageousability to restoring Hb. 2) Among the ironmetabolism-related indexes, serum iron(Fe), serum ferritin(Fer), total ironbinding capacity(TiBC) and liver tissue iron content were significantly higherin the WPP-Fe group than the ID group(P<0.05). 3) The liver malondialdehyde(MDA) content inthe MCOP-Fe and WPP-Fe group was significantly higher than the ID group(P<0.05), while the superoxidedismutase(SOD) content in the WPP-Fe and WPOP group showed a tendency to besuperior to other groups. 4) TNF-αconcentration was

关键词： Iron deficiency anemia pregnant rats Dietary oligopeptide(iron chelate)

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The Effect of INF-γ on Expression of IL-10 in Hypothalamus-Pituitary-Ovary Axis and Peripheral Blood of Early pregnant rats

The Effect of INF-γ on Expression of IL-10 in Hypothalamus-...

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中国畜牧兽医学会动物解剖及组织胚胎学分会第十九次学术研讨会

作者： Lifang Si Jian Li Mengyun Li Xiang Li College of Animal Science and Technology Henan University of Science and Technology

In order to investigate the effect of INF-γ on the expression of IL-10 in Hypothalamus-pituitary-ovary Axis and peripheral blood of early pregnant rats.9d pregnant rats were divided into control group,experimental group 1 and experimental *** of control group was injected physiological brine,rats of experimental group 1 and experimental group 2 were injected with 2.5×10U and 7.5×10U of IFN-γ each in vaginal muscular *** 48 h of the injection experiment materials were collected after perfusion from rats of each group,then staining by ultrasensitive immunohistochemistry SP *** the results were observed and *** results showed that 2.5×10U and 7.5×10U of IFN-γcould reduce the expression of IL-10 of Nucleus pre-opticus periventricularis,Nucleus supra-opticus,Nucleus pre-opticus mango cellularis,Nucleus pre-opticus medialis,Mucleus pre-opticus lateralis,Nucleus pre-opticus suprachiasmatic,Arcuate nucleus of the hypothalamus,Adenohypophysis,Corpus luteum of ovary,Stroma cells of uterus deciduas,uterine gland and peripheral *** told us that IFN-γ could reduce the expression of IL-10 in Hypothalamus-pituitary-ovary Axis and peripheral blood,High dose IFN-γshowed a much more significant down regulation.

关键词： IL-10 IFN-γ Immunohistochemistry Hypothalamus-pituitary-ovary Axis pregnant rats

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Effects of intrauterine infection in different periods on the placenta and endometrial blood vessel formation of pregnant mice and the growth and development of fetal rats

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Discussion of Clinical Cases 2021年第2期8卷 18-24页

作者： Xiao-li Geng Ya-xuan Zhang Qi-zhi Ren Department of Obstetrics and Gynecology the Third Affiliated Hospital of Inner Mongolia Medical UniversityBaotouInner MongoliaChina Department of Neurosurgery the First Affiliated Hospital of Baotou Medical CollegeBaotouInner MongoliaChina Department of Obstetrics and Gynecology Baogang HospitalBaotouInner MongoliaChina

Objective:To investigate the effects of intrauterine infection in different periods on the placenta and endometrial blood vessel formation of pregnant rats and the growth and development of fetal ***:According to the random number table method,32 pregnant rats were divided into the early infection group,the mid-term infection group,the late infection group and the control group,with 8 rats in each *** the 3rd,9th and 15th day of pregnancy,lipopolysaccharide was injected intraperitoneally to construct intrauterine infection *** pregnant rats in the control group were intraperitoneally injected with the same dose of 0.9%sodium chloride *** the 18th day of pregnancy,the inflammatory factors[interleukin-6(IL-6),tumor necrosis factor-(TNF-)],the blood vessel density of placenta and endometrium in the placental tissues of pregnant rats,dead fetus+absorbed fetus,the inflammatory factors IL-6,TNF-and oxidation reaction indicators[malondialdehyde(MDA)and myeloperoxidase(MPO)]in the fetal rat lung and brain tissues were ***:The changing trend of IL-6 and TNF-levels in the placental tissues of pregnant rats with intrauterine infection in different periods was:the control groupthe late infection group>the mid-term infection group>the early infection group,the differences were statistically significant(p<.05).The blood vessel density of placenta and endometrium,the mean number of fetuses,brain coefficient and lung coefficient in the late infection group were significantly increased in comparison with the early infection group and the mid-term infection *** total number and the ratio of dead fetus+absorbed fetus,the levels of IL-6,TNF-,MDA a

关键词： pregnant rats Intrauterine infection Inflammation Endometrium Blood vessel formation

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Folic acid supplementation attenuates hyperhomocysteinemia-induced preeclampsia-like symptoms in rats

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Neural Regeneration Research 2012年第25期7卷 1954-1959页

作者： Jun Wang Yan Cui Jing Ge Meijing Ma Department of Gynaecology and Obstetrics the 202 Hospital of People's Liberation Army Shenyang 110003 Liaoning Province China Department of Emergency Medicine General Hospital of Shenyang Military Region Shenyang 110016 Liaoning Province China Department of Gynaecology and Obstetrics the Second People's Hospital of Tongliao Tongliao 280000 Inner Mongolia AutonomousRegion China

Folic acid participates in the metabolism of homocysteine and lowers plasma homocysteine levels directly or indirectly. To establish a hyperhomocysteinemic pregnant rat model, 2 mL of DL-homocysteine was administered daily by intraperitoneal injection at a dose of 200 mg/kg from day 10 to day 19 of gestation. Folic acid was administered by intragastric administration at a dose of 20 mg/kg during the period of preeclampsia induction. Results showed that systolic blood pressure, proteinuria/creatinine ratio, and plasma homocysteine levels in the hyperhomocysteinemic pregnant rats increased significantly, and that body weight and brain weight of rat pups significantly decreased. Folic acid supplementation markedly reversed the above-mentioned abnormal changes of hyperhomocysteinemic pregnant rats and rat pups. These findings suggest that folic acid can alleviate the symptoms of hyperhomocysteinemia- induced preeclampsia in pregnant rats without influencing brain development of rat pups.

关键词： folic acid preeclampsia hyperhomocysteinemia proteinuria creatinine preeclampsia-likesymptom pregnant rats offspring brain nervous system regeneration neural regeneration

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