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Successful treatment of Morbihan disease with total glucosides of paeony:A case report

World Journal of Clinical Cases 2022年第19期10卷 6688-6694页

作者： Li-Feng Zhou Rong Lu Department of Dermatology The 942nd Hospital of the PLA Joint Logistic Support ForceYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Pathology The 942nd Hospital of the PLA Joint Logistic Support ForceYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Morbihan disease is a rare cutaneous disorder characterized by non-pitting edema and erythema of the upper two-thirds of the *** severe cases,orbital and facial contour changes may affect the visual field,and there is no guideline for the standard treatment of this *** treatment methods have been reported to be associated with long medication cycle,easy recurrence after drug withdrawal,and multiple adverse *** SUMMARY A 55-year-old Chinese woman presented to our hospital with non-pitting edema and erythema of the upper two thirds of her face for 5 *** examination showed obvious edema and erythema on the upper *** boundary was unclear,the lesions were hard and non-pitting,and infiltration was obvious by *** examination revealed mild hyperkeratosis of the epidermis,nodular inflammatory lesions in the dermis,epithelioid granuloma,and inflammatory cell infiltration with lymphocytes and histiocytes around skin appendages and blood *** blue staining,acid fast staining,silver staining and periodic acid-Schiff staining were *** patient was diagnosed with Morbihan *** was treated with prednisone acetate and tripterygium wilfordii polyglycoside tablets for 4 mo,and the edema was slightly reduced,but transaminase levels were significantly *** glycyrrhizin capsules were administered for liver protection for 1 mo;however,facial edema did not significantly improve and transaminase levels continued to *** glucosides of paeony capsules were then administered for 4 mo,and transaminase level returned to normal and the patient’s facial edema disappeared *** Total glucosides of paeony has a remarkable effect in Morbihan disease,without adverse reactions.

关键词： Morbihan disease Morbihan syndrome Total glucosides of paeony prednisone acetate Tripterygium wilfordii Case report

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