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Performance value of high risk factors in colorectal cancer screening in China

World Journal of Gastroenterology 2009年第48期15卷 6111-6116页

作者： Wen Meng Shan-Rong Cai Lun Zhou Qi Dong Shu Zheng Su-Zhan Zhang Cancer Institute (Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Key Laboratory of Molecular Biology in Medical Sciences Zhejiang Province China) The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310009 Zhejiang Province China Department of Cardiothoracic Surgery Hangzhou First People's Hospital Hangzhou 310006 Zhejiang Province China

AIM:To analyze the performance value of high risk factors in population-based colorectal cancer(CRC) screening in ***:We compared the performance value of the immunochemical fecal occult blood test(iFOBT) and other high risk factors questionnaire in a population sample of 13 214 community residents who completed both the iFOBT and questionnaire *** with either a positive iFOBT and/or questionnaire were regarded as a high risk population and those eligible were asked to undergo ***:The iFOBT had the highest positive predictive value and negative predictive value in screening for advanced *** iFOBT had the highest sensitivity,lowest number of extra false positive results associated with the detection of one extra abnormality for screening advanced neoplasias and adenomas.A history of chronic cholecystitis or cholecystectomy,chronic appendicitis or appendectomy,and chronic diarrhea also had a higher sensitivity than a history of adenomatous polyps in screening for advanced neoplasias and *** sensitivity of a history of chronic cholecystitis or cholecystectomy was highest among the 10 high risk factors in screening for nonadenomatous polyps.A history of chronic appendicitis or appendectomy,chronic constipation,chronic diarrhea,mucous and bloody stool,CRC in first degree relatives,malignant tumor and a positive iFOBT also had higher sensitivities than a history of adenomas polyps in screening for non-adenomatous *** for a history of malignant tumor in screening for non-adenomatous polyps,the gain in sensitivity was associated with an increase in extra false positive results associated with the detection of one extra ***:The iFOBT may be the best marker for screening for advanced neoplasias and *** unique high risk factors may play an important role in CRC screening in China.

关键词： Colorectal cancer Cancer screening Feces Occult blood Risk factors predictive value of tests

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Prediction of recurrence and prognosis in patients with hepatocellular carcinoma after resection by use of CLIP score

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World Journal of Gastroenterology 2002年第2期8卷 237-242页

作者： Wen He Zhao Zhi-Min Ma Xing-Ren Zhou Yi-Zheng Feng Bao-Shan Fang,Department of Oncosurgery,the First Affiliated Hospital,Zhejiang University,Medical College,Hangzhou 310003,Zhejiang Province,China Department of Oncosurgery the First Affiliated Hospital Zhejiang University Medical College 79 Qingchun Hangzhou 310003 Zhejiang Province China. zhaowh@***

AIM: The survival time of patients with hepatocellular carcinoma (HCC) after resection is hard to predict. Both residual liver function and tumor extension factors should be considered. A new scoring system has recently been proposed by the Cancer of the Liver Italian Program (CLIP). CLIP score was confirmed to be one of the best ways to stage patients with HCC. To our knowledge, however, the literature concerning the correlation between CLIP score and prognosis for patients with HCC after resection was not published. The aim of this study is to evaluate the recurrence and prognostic value of CLIP score for the patients with HCC after resection. METHODS: A retrospective survey was carried out in 174 patients undergoing resection of HCC from January 1986 to June 1998. Six patients who died in the hospital after operation and 11 patients with the recurrence of the disease were excluded at 1 month after hepatectomy. By the end of June 2001, 4 patients were lost and 153 patients with curative resection have been followed up for at least three years. Among 153 patients, 115 developed intrahepatic recurrence and 10 developed extrahepatic recurrence, whereas the other 28 remained free of recurrence. Recurrences were classified into early (3 year) recurrence. The CLIP score included the parameters involved in the Child-Pugh stage (0-2), plus macroscopic tumor morphology (0-2), AFP levels (0-1), and the presence or absence of portal thrombosis (0-1). By contrast, portal vein thrombosis was defined as the presence of tumor emboli within vascular channel analyzed by microscopic examination in this study. Risk factors for recurrence and prognostic factors for survival in each group were analyzed by the chi-square test, the Kaplan-Meier estimation and the COX proportional hazards model respectively. RESULTS: The 1-, 3-, 5-, 7-,and 10-year disease-free survival rates after curative resection of HCC were 57.2%, 28.3%, 23.5%, 18.8%, and 17.8%, respect

关键词： Neoplasm Recurrence, Local Adolescent Adult Aged Carcinoma, Hepatocellular Child Disease-Free Survival Female Humans Liver Neoplasms Male Middle Aged Neoplasm Staging predictive value of tests Prognosis Retrospective Studies Risk Factors

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Expressions of ICAM-1 and its mRNA in sera and tissues of patients with hepatocellular carcinoma

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World Journal of Gastroenterology 2001年第1期7卷 120-125页

作者： Jing Xu1 Ming Hui Mei1 Si En Zeng2 Qing Fen Shi3 Yong Ming Liu4 Li Ling Qin3 1Department of Hepatobiliary Surgery2Department of Pathology3Institute of Hepatobiliary Surgery4Department of Biochemistry, Guilin 541001, Guangxi Province, China 95 Leque Road Department of Hepatobiliary Surgery Guilin Medical College Guilin 541001 Guangxi China. Jxu@***

INTRODUCTIONThe increased expression of ICAM-1 on a widerange of cells and in the sera of patients withmalignancies, chronic liver diseases andinflammation diseases has been described since thelate 1980s[1-22]. Recently rapid progress in studieson expression of ICAM-1 in patients withhepatocellular carcinoma ( HCC ) have beenachieved, including clinical and experimentalresearches[23-31].

关键词： Carcinoma, Hepatocellular Follow-Up Studies Humans Immunohistochemistry Intercellular Adhesion Molecule-1 Liver Liver Neoplasms predictive value of tests Prognosis RNA, Messenger Radioimmunoassay Research Support, Non-U.S. Gov't Reverse Transcriptase Polymerase Chain Reaction Solubility alpha-Fetoproteins

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Contrast-enhanced ultrasonography assessment of gastric cancer response to neoadjuvant chemotherapy

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World Journal of Gastroenterology 2012年第47期18卷 7026-7032页

作者： Jian Ang Liang Hu Pin-Tong Huang Jin-Xiu Wu Ling-Na Huang Chun-Hui Cao Yi-Xiong Zheng Li Chen Department of Gastroenterology the Second Affiliated HospitalZhejiang University School of Medicine Department of Surgery the Second Affiliated HospitalZhejiang University School of Medicine Binjiang Hospital the Second Affiliated Hospital(Binjiang Branch)Zhejiang University School of Medicine Department of Ultrasonography the Second Affiliated HospitalZhejiang University School of Medicine Department of Radiology the Second Affiliated HospitalZhejiang University School of Medicine

AIM:To quantitatively assess the ability of double contrast-enhanced ultrasound(DCUS) to detect tumor early response to pre-operative ***:Forty-three patients with gastric cancer treated with neoadjuvant chemotherapy followed by curative resection between September 2011 and February 2012 were ***-operative chemotherapy regimens of fluorouracil + oxaliplatin or S-1 + oxaliplatin were administered in 2-4 cycles over 6-12 wk *** patients underwent contrast-enhanced computed tomography(CT) scan and DCUS before and after two courses of pre-operative *** therapeutic response was assessed by CT using the response evaluation criteria in solid tumors(RECIST 1.1) *** area was assessed by DCUS as enhanced appearance of gastric carcinoma due to tumor vascularity during the contrast phase as compared to the normal gastric *** analysis was carried out according to the Mandard tumor regression grade criteria and used as the reference *** operating characteristic(ROC) analysis was used to evaluate the efficacy of DCUS parameters in differentiating histopathological responders from ***:The study population consisted of 32 men and 11 women,with mean age of 59.7 ± 11.4 *** age,sex,histologic type,tumor site,T stage,nor N stage was associated with pathological *** responders had significantly smaller mean tumor size than the non-responders(15.7 ± 7.4 cm vs 33.3 ± 14.1 cm,P < 0.01).According to Mandard's criteria,27 patients were classified as responders,with 11(40.7%) showing decreased tumor size by *** contrast,only three(18.8%) of the 16 non-responders showed decreased tumor size by DCUS(P < 0.01).The area under the ROC curve was 0.64,with a 95%CI of *** effects of several cut-off points on diagnostic parameters were calculated in the ROC curve *** maximizing Youden's index(sensitivity + specificity-1),the best cut-off point for distingu

关键词： Gastric cancer Chemotherapy Ultrasonic imaging predictive value of tests Disease management

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External validation of the Prostate Cancer Prevention Trial and the European Randomized Study of Screening for Prostate Cancer risk calculators in a Chinese cohort

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Asian Journal of Andrology 2012年第5期14卷 738-744页

作者： Yao Zhu Jin-You Wang Yi-Jun Shen Bo Dai Chun-Guang Ma Wen-Jun Xiao Guo-Wen Lin Xu-Dong Yao Shi-Lin Zhang Ding-Wei Ye Department of Urology Fudan University Shanghai Cancer Center Shanghai 200032 China Department of Oncology Shanghai Medical College Fudan University Shanghai 200032 China

Several prediction models have been developed to estimate the outcomes of prostate biopsies. Most of these tools were designed for use with Western populations and have not been validated across different ethnic groups. Therefore, we evaluated the predictive value of the Prostate Cancer Prevention Trial （PCPT） and the European Randomized Study of Screening for Prostate Cancer （ERSPC） risk calculators in a Chinese cohort. Clinicopathological information was obtained from 495 Chinese men who had undergone extended prostate biopsies between January 2009 and March 2011. The estimated probabilities of prostate cancer and high-grade disease （Gleason 〉6） were calculated using the PCPT and ERSPC risk calculators. Overall measures, discrimination, calibration and clinical usefulness were assessed for the model evaluation. Of these patients, 28.7% were diagnosed with prostate cancer and 19.4% had high-grade disease. Compared to the PCPT model and the prostate-specific antigen （PSA） threshold of 4 ng m1-1, the ERSPC risk calculator exhibited better discriminative ability for predicting positive biopsies and high-grade disease （the area under the curve was 0.831 and 0.852, respectively, P〈O.01 for both）. Decision curve analysis also suggested the favourable clinical utility of the ERSPC calculator in the validation dataset. Both prediction models demonstrated miscalibration： the risk of prostate cancer and high-grade disease was overestimated by approximately 20% for a wide range of predicted probabilities. In conclusion, the ERSPC risk calculator outperformed both the PCPT model and the PSA threshold of 4 ng ml- z in predicting prostate cancer and high-grade disease in Chinese patients. However, the prediction tools derived from Western men significantly overestimated the probability of prostate cancer and high-grade disease compared to the outcomes of biopsies in a Chinese cohort.

关键词： European Randomized Study of Screening for Prostate Cancer (ERSPC) predictive value of tests prostate cancer prostate-specific antigen (PSA) Prostate Cancer Prevention Trial (PCPT)

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Biliary carcinoembryonic antigen levels in diagnosis of occult hepatic metastases from colorectal carcinoma

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World Journal of Gastroenterology 2003年第7期9卷 1589-1593页

作者： Jaques Waisberg Rogério T.Palma Luís Contim Neto Lourdes C.Martins Maurício S.L.Oliveira Carlos A. Nagashima Antonio C.Godoy Fabio S.Goffi Surgical Gastroenterology Department Hospital do Servidor Público EstadualSo PauloBrazil Clinical Laboratory Department Hospital do Servidor Público EstadualSo PauloBrazil

AIM:To prospectively explore the role of carcinoembryonic antigen (CEA) in gallbladder bile in patients with colorectal carcinoma and the morphological and clinical features of neoplasia and the occurrence of hepatic metastases. METHODS:CEA levels in the gallbladder and peripheral blood were studied in 44 patients with colorectal carcinoma and 10 patients with uncomplicated *** samples were collected from the gallbladder bile and peripheral blood during the operation,immediately before extirpating the colorectal neoplasia or cholecystectomy. values of up to 5 ng/ml were considered normal for bile and serum CEA. RESULTS:In the 44 patients with colorectal carcinoma who underwent operation with curative intent,the average level of serum CEA was 8.5 ng/ml (range:0.1 to 111.0 ng/ ml) and for bile CEA it was 74.5 ng/ml (range:0.2 to 571.0 ng/ml).In the patients with uncomplicated cholelithiasis who underwent cholecystectomy,the average level of serum CEA was 2.9 ng/ml (range:1.0 to 3.5 ng/ml) and for bile CEA it was 1.2 ng/ml (range:0.3 to 2.9 ng/ml). The average duration of follow-up time was 16.5 months (range:6 to 48 months).Four patients who underwent extirpation of the colorectal carcinoma without evidence of hepatic metastasis and with an average bile CEA value of 213.2 ng/ml presented hepatic metastases between three and seventeen months after removal of the primary colorectal *** of them successfully underwent extirpation of the hepatic lesions. CONCLUSION:High CEA levels in gallbladders of patients undergoing curative operation for colorectal carcinoma may indicate the presence of hepatic *** patients must be followed up with special attention to the diagnosis of such lesions.

关键词： Adult Aged Aged, 80 and over Bile Carcinoembryonic Antigen Cholecystectomy Cholelithiasis Colorectal Neoplasms Female Humans Liver Neoplasms Male Middle Aged predictive value of tests Prospective Studies

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Levels of v5 and v6 CD44 splice variants in serum of patients with colorectal cancer are not correlated with pT stage,histopathological grade of malignancy and clinical features

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World Journal of Gastroenterology 2004年第4期10卷 583-585页

作者： Bogdan Zalewski 2nd Department of General and Gastroenterological Surgery Medical University of BialystokPoland

AIM:This study was designed to compare the levels of v5 and v6 splice variants of CD44 evaluated using EITSA test in the serum of patients with colorectal cancer in different stages of progression of the disease estimated in pT stage according to WHO score,histopathological grade of malignancy and some clinicopathological features. METHODS:The serum obtained from 114 persons with colorectal adenocarcinomas was examined using ELISA method,pT stage and grade of malignancy of the tumour were examined in formalin fixed and paraffin embedded materials obtained during operation. RESULTS:Only the level of CD44 v5 in the serum of patients before operation with G2 pT4 tumour was lower than that in other probes and the difference was statistically significant. We did not find any other correlations between the level of v5 and v6 CD44 variants and other evaluated parameters. CONCLUSION:The level of CD44 v5 and v6 estimated by ELISA test in the serum can not be used as a prognostic factor in colorectal cancer.

关键词： Alternative Splicing Adenocarcinoma Adult Aged Aged, 80 and over Antigens, CD44 Colorectal Neoplasms Disease Progression Enzyme-Linked Immunosorbent Assay Female Humans Male Middle Aged predictive value of tests Prognosis Tumor Markers, Biological

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Severity of gastroesophageal reflux disease influences daytime somnolence: A clinical study of 134 patients underwent upper panendoscopy

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World Journal of Gastroenterology 2004年第12期10卷 1798-1801页

作者： Pái Demeter Katalin Várdi Visy Nóra Gyulai Róbert Sike Tamás G Tóth János Novák Pál Magyar Outpatient Clinic of Gastroenterology St.John's HospitalBudapestHungary Department of Pulmonology Semmelweis Medical UniversityBudapestHungary Dept.of

AIM: To asses the relationship between severity of gastroesophageal refluxe disease and Epworth sleepiness scale as an indicator of daytime somnolence. METHODS: One hundred and thirty-four patients underwent an upper panendoscopy as indicated by the typical reflux symptoms and were also investigated with regard to somnolence. Sleepiness was evaluated by Epworth Sleepiness Scale, which was compared to the severity of endoscopic findings (Savary-Miller/modified by Siewert). Patients with psychiatric disorders or being on sedato-hypnotics as well as shift workers were excluded from the study. The relationship between the severity of the reflux disease and daytime somnolence was analyzed with the help of multivariate regression analysis. RESULTS: A positive tendency was found between the severity of the reflux disease and the corresponding Epworth Sleepiness Scale. In the case of the more severe type-Savary-Miller Ⅲ- at least a mild hypersomnia was found. For this group daytime somnolence was significantly higher than in the case of the non-erosive type of Gastroesophageal Reflux Disease representing the mildest stage of reflux disease. CONCLUSION: The severity of Gastroesophageal Reflux Disease influences daytime somnolence.

关键词： Severity of Illness Index Adult Aged Disorders of Excessive Somnolence Endoscopy, Digestive System Female Gastroesophageal Reflux Humans Linear Models Male Middle Aged predictive value of tests

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Identification of the epitopes on HCV core protein recognized by HLA-A2 restricted cytotoxic T lymphocytes

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World Journal of Gastroenterology 2001年第4期7卷 583-586页

作者： Hong-Chao Zhou De-Zhong Xu Xue-Ping Wang Jing-Xia Zhang Ying-Huang Yong-Ping Yan Yong Zhu Bo-Quan Jin Department of Epidemiology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,ChinaDepartment of Immunology,the Fourth Military Medical University,Xi’an 710033,Shaanxi Province,China Department of Immunology the Fourth Military Medical University Xi'an 710033 Shaanxi Province China. juliu@***

AIM: To identify hepatitis C virus(HCV) core protein epitopes recognized by HLA-A2 restricted cytotoxic T lymphocyte (CTL). METHODS: Utilizing the method of computer prediction followed by a 4h(51)Cr release assay confirmation. RESULTS: The results showed that peripheral blood mononuclear cells (PBMC) obtained from two HLA-A2 positive donors who were infected with HCV could lyse autologous target cells labeled with peptide "ALAHGVRAL (core 150-158)". The rates of specific lysis of the cells from the two donors were 37.5% and 15.8%, respectively. Blocking of the CTL response with anti-CD4 mAb caused no significant decrease of the specific lysis. But blocking of CTL response with anti-CD8 mAb could abolish the lysis. CONCLUSION: The peptide (core 150-158) is the candidate epitope recognized by HLAA2 restricted CTL.

关键词： Amino Acid Sequence Antibodies, Viral B-Lymphocytes Cell Line Epitope Mapping HLA-A2 Antigen Hepacivirus Hepatitis C Humans Peptide Fragments predictive value of tests Research Support, Non-U.S. Gov't T-Lymphocytes, Cytotoxic Viral Core Proteins

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Role of oxygen free radicals in patients with acute pancreatitis

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World Journal of Gastroenterology 2003年第10期9卷 2266-2269页

作者： Byung Kyu Park Jae Bock Chung Jin Heon Lee Jeong Hun Suh Seung Woo Park Si Young Song Hyeyoung Kim Kyung Hwan Kim Jin Kyung Kang Department of Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea Department of Pharmacology College of MedicineYonsei UniversitySeoulKorea Departmentof Internal Medicine Institute of GastroenterologyCollege of MedicineYonsei UniversitySeoulKorea

AIM:The generation of oxygen free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen free radicals in patients with acute pancreatitis. METHODS:The plasma levels of C-reactive protein(CRP), lipid peroxide(LPO),myeloperoxidase(MPO)and superoxide dismutase(SOD)were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. RESULTS:Among the patients with acute pancreatitis,there were higher plasma levels of LPO and MPO and lower SOD activity in patients with severe pancreatitis than in those with mild ***,there was no significant difference in the serum marker of oxidative stress no matter what the etiology *** LPO level was especially correlated with the concentration of serum CRP and CT severity index. CONCLUSION:The oxygen free radicals may be closely associated with inflammatory process and the severity of acute ***,the concentration of plasma LPO is a meaningful index for determining the severity of the disease.

关键词： Oxidative Stress Severity of Illness Index Acute Disease Adult Aged Female Humans Lipid Peroxides Male Middle Aged Pancreatitis Peroxidase predictive value of tests Prognosis Reactive Oxygen Species Superoxide Dismutase

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