检索结果-南通市图书馆

High nitrogen stainless steel drug-eluting stent-Assessment of pharmacokinetics and preclinical safety in vivo

Bioactive Materials 2020年第4期5卷 779-786页

作者： Shanshan Chen Zhifeng Yao Yongbiao Guan Hui Yang M.Babar Shahzad Yizhe Wu Bingchun Zhang Li Shen Ke Yang Institute of Metal Research Chinese Academy of Sciences72 Wenhua RoadShenyang110016China Shanghai Institute of Cardiovascular Diseases Department of CardiologyZhongshan HospitalFudan University180 Fenglin RoadShanghai200032China National Beijing Center for Drug safety Evaluation and Research Beijing Institute of Pharmacology and ToxicologyAcademy of Military Medical Sciences27 Taiping RoadHaidian DistrictBeijing100850People's Republic of China

Pharmacokinetic analyses were performed using 20 pigs for 120-days implantation,while one sirolimus-eluting stent was implanted into one of their coronary artery.At different time points,the residual sirolimus on the stent,delivered locally(to artery wall),regionally(to adjacent and downstream muscle)and systemically(to plasma and visceral organs),was detected throughout 120 days.preclinical safety evaluation was performed using 32 pigs for 180-days implantation to study the safety of metal platform material and the effectiveness of sirolimus eluting coating on the HNS stent.The neointima area,restenosis rate and inflammatory grade for HNS and control group stents were detected and analyzed.Approximately 80%sirolimus was eluted from the sirolimuseluting stents after 30-days implantation in vivo.Additionally,there was sustained sirolimus in the artery wall,cardiac muscle and heart throughout 120-days implantation,and sirolimus accumulated to the peak at 90-days implantation.It was inferred that the sirolimus eluting stent in this study was covered by neointima before 90-days implantation,indicating that the sirolimus eluting coating on the HNS stent was safe and effective.Very little sirolimus was distributed in visceral organs after 14-days implantation.HNS sirolimus-eluting stent exhibited lower restenosis rate and lower inflammatory grade than control group,which verified that the sirolimus-eluting coating design in this study was reasonable and practical.In addition,there were no significant difference in restenosis rate and inflammatory score between HNS bare-metal stent and drug-eluting stents,illustrating that HNS has good bio-compatibility and is suitable to use as coronary artery stent material.

关键词： Sirolimus-eluting stent Pharmacokinetics preclinical safety Tissue response

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：