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Association between pre-pregnancy Body Mass Index and Offspring Neuropsychological Development from 1 to 24 Months of Age: A Birth Cohort Study in China

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Biomedical and Environmental Sciences 2019年第10期32卷 730-738页

作者： CAO Lu Jia LIN Hong Yan LIANG Xuan CHEN Yong Jie LIU Yu Yan ZHENG Yu Zhi WANG Xin Yan LI Wen YAN Jing HUANG Guo Wei Department of Nutrition and Food Science School of Public HealthTianjin Medical UniversityTianjin 300070China Tianjin Key Laboratory of Environment Nutrition and Public HealthTianjin 300070China Department of Epidemiology and Statistics School of Public HealthTianjin Medical UniversityTianjin 300070China Department of Social Medicine and Health Administration School of Public HealthTianjin Medical UniversityTianjin 300070China

Objective To explore the interactions between pre-pregnancy body mass index(BMI) and age on offspring neuropsychological development from 1 to 24 months in *** In this birth cohort study, a total of 2,253 mother-child pairs were enrolled in Tianjin, China,between July 2015 and May 2018. The China Developmental Scale for Children was used to assess developmental quotient(DQ) of children aged from 1 to 24 *** Mixed-models analysis revealed significant age × pre-pregnancy BMI interactions for total DQ and five neurobehavioral domains(gross motor, fine motor, adaptive, language, and social;P pre-pregnancy BMI ≥ 25 kg/m^2 was associated with a negative effect on total DQ and five neurobehavioral domains, as compared to pre-pregnancy BMI pre-pregnancy BMI ≥ 25 kg/m^2 of mothers had a positive effect on child total DQ at the age of 1 month but a negative effect at 24 months(P pre-pregnancy BMI interaction on offspring neuropsychological development. It also revealed a short-term positive impact of high pre-pregnancy BMI on neuropsychological development at 1 month of age, but a long-term negative effect(from 1 to24 months).

关键词： pre-pregnancy BMI Neuropsychological development Offspring The first 1,000 days Birth cohort study

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Adverse pregnancy outcomes in women with high pre-pregnancy body mass index

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Open Journal of Obstetrics and Gynecology 2013年第2期3卷 285-291页

作者： Rajin Arora Darin Arora Jayanton Patumanond Clinical Epidemiology Unit Chiang Mai University Chiang Mai Thailand Department of Obstetrics and Gynecology Lampang Regional Hospital Lampang Thailand

Background/Aims: Obesity along with high prepregnancy body mass index (PP-BMI) is known to cause many adverse pregnancy outcomes. In Thailand, there is not much study showing both the prevalence and complications of these conditions. The objectives of this study were to estimate the prevalence of prepregnancy overweight and obesity and their impacts on adverse pregnancy outcomes. Methods: This study was a cross sectional study. Data were collected retrospectively from hospital electronic database along with manual retrieval from medical charts and labor records. Data of all delivery women from 1st February 2011 to 31st August 2012 were collected. When excluded cases with incomplete data and those without PP-BMI, 5420 cases were into analysis. Descriptive and inferential data analyses were used with both univariate and multivariate methods. Results: The proportion of pregnant women with overweight and obesity were 11.1% and 3.9%. After multiple logistic regression analysis was done, women in obesity group were correlated with having 1, 2 and 3 complications. They were also correlated with preeclampsia, gestational diabetes, cesarean section, higher birth weight group and long neonatal length. Conclusions: This Thai prevalence of obesity in pregnancyshould alarm health care providers to be more prepared, for a future health problem of the country. Many complications that come with obese pregnant women that were reported in western countries also happen in Thai population. Decreasing body weight before conception, giving correct health education, well planned pregnancy;antenatal lifestyle intervention and even gestational weight gain restricttion could help avoiding these uneventful morbidities.

关键词： pre-pregnancy Body Mass Index Obesity pregnancy prevalence pregnancy Outcome

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Weight Gain: A Modifiable Risk Factor for Primary Cesarean Delivery

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Open Journal of Obstetrics and Gynecology 2017年第5期7卷 525-531页

作者： Annelee Boyle Julia Timofeev Sameer Desale Rita W. Driggers Donald J. Dudley Department of Obstetrics and Gynecology MedStar Washington Hospital Center Washington DC USA Department of Gynecology and Obstetrics Johns Hopkins University School of Medicine Baltimore MD USA MedStar Health Research Institute Hyattsville MD USA Department of Obstetrics and Gynecology University of Virginia School of Medicine Charlottesville VA USA

Objective: To evaluate the relationship between weight gain and primary cesarean delivery. Methods: This was a retrospective cohort study of women 5442 who delivered a singleton from 2009-2013. Women were classified as normal weight [pre-pregnancy body mass index (BMI) 18.5 - 24.9 kg/m2], overweight (pre-pregnancy BMI 25.0 - 29.9 kg/m2), obese (pre-pregnancy BMI 30.0 - 39.9 kg/m2), and extremely obese (pre-pregnancy BMI ≥ 40.0 kg/m2). Each BMI group was subdivided by weight gain—low, recommended, or excessive, as defined by the 2009 Institute of Medicine guidelines—and rates of primary cesarean delivery were compared. Results: The overall primary cesarean delivery rate was 27.3%, but this varied based on pre-pregnancy BMI. The primary cesarean delivery rate among women of normal weight was 22.3%, overweight women 27.5%, obese women 35.3%, and extremely obese women 45.7%. Among normal-weight, obese, and extremely obese women, the risk of primary cesarean delivery increased with excessive weight gain [normal weight odds ratio (OR) 1.63, (95% confidence interval 1.32 - 2.01);obese OR 1.55 (1.12 - 2.15);extremely obese OR 2.19 (1.18 - 4.08)] compared to recommended weight gain. More than half of women (53.2%) had excessive weight gain. Conclusion: Adherence to guidelines may decrease a woman’s risk of primary cesarean delivery.

关键词： Primary Cesarean Weight Gain pre-pregnancy BMI Obese Obesity

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