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Effect of diluted povidone iodine in adenoviral keratoconjunctivitis on the rate of subepithelial corneal infiltrates

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1420-1425页

作者： Rana Altan-Yaycioglu Nedime Sahinoglu-Keskek Handan Canan Muge Coban-Karatas Burak Ulas Department of Ophthalmology Baskent University School of Medicine

AIM: To evaluate the clinical characteristics of adenoviral keratoconjunctivitis, the management modalities, as well as the incidence of subepithelial corneal infiltrates(SEI).METHODS: Patients with characteristic clinical symptoms and signs, who presented to our clinic within the first week of symptoms and received the diagnosis of adenoviral keratoconjunctivitis between January 2013 and April 2016, were included in the study. A total of 211 patients were included in the study. Patients were evaluated for the incidence of clinical signs, late complications, management preferences, and the effect of diluted povidone-iodine(d-PVP-I) 2%. RESULTS: Patients’ mean age was 33.03±14.76 y. We observed an increase in the number of cases according to the years. At presentation and/or early follow-up, the clinical signs were conjunctival hyperemia(100%), conjunctival follicules(79.1%), edema of the eyelids(39.3%), chemosis(16.1%), pseudomembrane formation(16.6%), and corneal epitheliopathy(29.9%). During late follow-up 13.3% patients developed conjunctival subepithelial fibrosis, and 39.8% developed SEI. A significant decrease in the incidence of SEI development was observed in patients who used d-PVP-I 2%(P=0.032;33.3% vs 45.9%, respectively in patients who received d-PVP-I 2% and who did not).CONCLUSION: Adenoviral keratoconjunctivitis has a tremendous effect on patient’s comfort and abilities in short-term. Additionally, almost half of the patients develop visual problems related to SEI. According to our clinical experience, using d-PVP-I 2% in the first days of adenoviral keratoconjunctivitis might be helpful in reducing the risk of SEI as a complication.

关键词： conjunctivitis corneal opacity infectious keratoconjunctivitis keratoconjunctivitis povidone-iodine viral conjunctivitis

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Successful prolonged cardiopulmonary resuscitation after intraoperative cardiac arrest due to povidone-iodine allergy: A case report

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World Journal of Clinical Cases 2021年第33期9卷 10362-10368页

作者： Bing-Bing Xiang Yu-Ting Yao Shu-Lan Jiao Department of Anesthesiology Chengdu Fifth People's HospitalChengdu 611130Sichuan ProvinceChina Department of Anesthesiology The Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of Anesthesiology The Second Affiliated Hospital of Kunming Medical UniversityKunming 650101Yunnan ProvinceChina

BACKGROUND Iodophor(povidone-iodine)is widely used clinically because of its broadspectrum antibacterial effects.Although extremely rare,it may cause anaphylactic shock,which itself carries the life-threatening risk of cardiac arrest.CASE SUMMARY We present a case in which a patient with postoperative infection went into anaphylactic shock and cardiac arrest caused by povidone-iodine during secondary surgery.The patient was successfully resuscitated by 2 h of cardiopulmonary resuscitation.CONCLUSION This is the first known case of cardiac arrest caused by povidone-iodine allergy.

关键词： povidone-iodine Allergy Anaphylactic shock Cardiac arrest Cardiopulmonary resuscitation Case report

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Ototoxicity of povidone-iodine——A case report

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Journal of Otology 2019年第1期14卷 30-32页

作者： Patorn Piromchai Department of Otorhinolaryngology Faculty of Medicine Khon Kaen University

Objective: The ototoxicity of povidone-iodine has been documented in animal studies. However, there is limited evidence of these ototoxic effects in humans. This is the first report to show the ototoxic effects of povidoneiodine in a human subject.Patient: A 36-year-old woman came to our hospital complaining of left unilateral persistent hearing loss. One month before presentation, her child had accidentally struck her on her left ear. She applied approximately three drops of povidone-iodine(10% weight/volume) into her left auditory canal. Immediately after application, she felt severe pain and vertigo. An audiogram revealed severe left unilateral sensorineural hearing loss. Magnetic resonance imaging showed mild enhancement of the left vestibule and basal turn of the left cochlea.Conclusions: Even a single application of povidone-iodine could cause significant hearing loss and disequilibrium. It should, therefore, be used with caution.

关键词： povidone-iodine Ototoxicity

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Antibacterial effect of povidone iodine disinfectant and antibiotic eye drops before cataract surgery

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Discussion of Clinical Cases 2022年第3期9卷 5-12页

作者： Qin Zhao Department of Ophthalmology Baogang HospitalBaotouInner MongoliaChina

Objective:Investigate the distribution of bacteria in the conjunctival sac of two groups of cataract patients with different preoperative aseptic treatments,and compare the clinical effects of 0.5%povidone-iodine(PI)and antibiotic eye drops on killing conjunctival sac bacteria.Methods:400 cases of patients(400 eyes)who underwent cataract surgery in the Department of Ophthalmology of Baogang Hospital in Inner Mongolia from October 2019 to October 2020 were selected in a randomized controlled study.They were randomly divided into the experimental group(group A)and the control group(group B),with 200 cases in each group.Group A:the patients were given Gatiﬂoxacin Eye Gel(3 times/day,1 drop/time)combined with Diclofenac Sodium Eye Drops(4 times/day,1 drop/time)before the operation;0.5%PI was administered to irrigate the conjunctival sac,with 0.9%Sodium Chloride Injection washing after 3 min;0.5%PI was administered to irrigate the conjunctival sac after operation.The corneal epithelium was observed after each irrigation.Group B:the patients were given Gatiﬂoxacin Eye Gel(3 times/day,1 drop/time)combined with Diclofenac Sodium Eye Drops(4 times/day,1 drop/time)2 days and 1 day before the operation;0.9%Sodium Chloride Injection was administered to irrigate the conjunctival sac before and after surgical disinfection.Conjunctival sac specimens were collected for bacterial culture 2 hours before the operation,after irrigation,and after the procedure.The positive rate and the distribution of bacteria were compared between the two groups.Results:The difference in the positive rate of bacteria in the conjunctival sac between the two groups at different time points had a statistical significance(χ^(2)=11.498,p<.022).Conjunctival sac specimens were collected on admission and 2 hours before the operation.There was no significant difference in the pathogens with positive results between the two groups(p=.955;p=.073);there was a substantial difference in the distribution of positive pathogens between the two groups before and afte

关键词： Cataract extraction povidone-iodine Conjunctival sac irrigation Bacterial culture Corneal epithelium

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Evaluation of a povidone-iodine and chitosan-based barrier teat dip in the prevention of mastitis in dairy cows

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Journal of Integrative Agriculture 2021年第6期20卷 1615-1625页

作者： HANG Hui-min JIANG Hong-rui CHEN Dai-jie SHEN Zi-liang MAO Yong-jiang LIANG Yusheng Juan JLOOR YANG Zhang-ping Key Laboratory for Animal Genetics BreedingReproduction and Molecular Design of Jiangsu ProvinceCollege of Animal Science and TechnologyYangzhou UniversityYangzhou 225009P.R.China Joint International Research Laboratory of Agriculture&Agri-Product Safety Ministry of Education/Yangzhou UniversityYangzhou 225009P.R.China Department of Animal Sciences&Division of Nutritional Sciences University of IllinoisUrbanaIL 61801USA

Postmilking teat dip is an important tool used to prevent mastitis in the modern dairy industry.In this study,we evaluated the in vitro and in vivo efficacies of a barrier teat dip containing povidone-iodine and chitosan for the prevention of mastitis.In experiment 1,we evaluated the antibacterial effects of chitosans with different molecular weights against six mastitis-causing bacteria based on the minimal inhibitory concentration test.The results showed that 50 k Da chitosan had the maximum antibacterial activity compared with 5,150 and 350 k Da chitosans.In experiment 2,the inhibition zone test indicated that the barrier teat dip with 4.0%povidone-iodine and 1.0%chitosan had higher(Ppovidone-iodine and no chitosan.In experiments 3 and 4,we evaluated the efficacies of two postmilking teat dips,1)a barrier teat dip containing 1.0%chitosan and 4.0%povidone-iodine and 2)a conventional nonbarrier product containing 10%povidone-iodine in a field trial at two commercial dairy herds(1 and 2).A 56-d split-udder experiment(experiment 3)was conducted using 47 lactating Chinese Holstein cows in herd 1.Both left teats were immersed in barrier postmilking dip,and both right teats were dipped with nonbarrier postmilking dip.During a 56-d split-herd experiment(experiment 4),a total of 139 lactating Chinese Holstein cows from herd 2 were allocated to two groups:1)all teats of 67 cows were dipped in the nonbarrier teat dip,and 2)all teats of 72 cows were dipped in the barrier teat dip.Milk samples were collected and analyzed for somatic cell count(SCC),fat content,protein content,and fat-to-protein ratio prior to the start of sampling(0 d),and at 28 and 56 d after initiation.Bacteriological analysis was only performed on milk samples with SCC≥200000 cells mL^(-1).In experiment 3,no differences(P>0.05)in SCC,somatic cell score(SCS)or other milk quality indicators were observed between nonbarrier and barrier tea

关键词： mastitis povidone-iodine chitosan barrier postmilking dip

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Effects of povidone-iodine or Ethanol Exposure on Bone Formation at the Osteotomy Site of the Proximal Tibia in Rats

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Open Journal of Orthopedics 2019年第12期9卷 265-272页

作者： Itsuki Nagahata Naohisa Miyakoshi Yuji Kasukawa Hiroyuki Tsuchie Yusuke Yuasa Manabu Akagawa Yuichi Ono Chiaki Sato Koji Nozaka Michio Hongo Yoichi Shimada Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: povidone-iodine (PVI) irrigation is currently used to decrease the frequency of postoperative surgical site infections. Ethanol (EtOH) is sometimes applied to prevent local recurrence after curettage of benign bone tumors. However, the effects of PVI and EtOH on surrounding soft tissue and on bone union are unclear. The purpose of this study was to determine whether PVI or EtOH adversely affects the cancellous bone healing of the osteotomy site at the proximal tibia in rats. Methods: A cancellous bone osteotomy was performed at the right proximal tibia in 4-month-old, female, Sprague Dawley rats. Vehicle, 10% PVI, or 95% EtOH-soaked gauze was inserted into the osteotomy site and maintained for 6 minutes. The rats were euthanized 2 or 4 weeks after the osteotomy. Results: Two weeks after treatment, the bone union rate was significantly higher in the vehicle group than in the PVI group and the EtOH group (p < 0.001). However, the bone union rate was not significantly different between the PVI and EtOH groups. There was no significant difference among the three groups in the bone union rate 4 weeks after treatment. Conclusion: PVI or EtOH delayed bone union of the cancellous bone osteotomy site of the proximal tibia in the early phase (2 weeks), but not at 4 weeks, in rats.

关键词： Cancellous Bone Union povidone-iodine Ethanol

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Effect of hand hygiene intervention on the absenteeism of pre-school children in Klang Valley,Malaysia:a quasi-experimental study

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World Journal of Pediatrics 2020年第4期16卷 416-421页

作者： Nurul Azmawati Mohamed Mohd Dzulkhairi Mohd Rani Tengku Zetty Maztura Tengku Jamaluddin Zarini Ismail Shalinawati Ramli Habibah Faroque Farisha Nur Abd Samad Abdul Rashid Ariffien Aisyah Ar Redha Che Amir FaridIlina Isahak Faculty of Medicine and Health Sciences Universiti Sains Islam MalaysiaPandan Indah55100Kuala LumpurMalaysia Faculty of Medicine and Health Sciences Universiti Putra Malaysia43400SerdangSelangorMalaysia

Background Absenteeism amongst pre-school children is often due to illnesses such as hand,foot,and mouth disease,acute gastroenteritis,cold and flu,which are easily spread amongst them.This is because of weak immunity and lack of knowledge on proper hand hygiene.This quasi-experimental study assessed the efficacy of an intervention consisting of a hand hygiene education programme,along with digital tools in bringing about a change in behaviour and health conditions amongst pre-school children in Klang Valley,Malaysia.Methods A total of 377 school children,male and female,aged 5–6 years old,participated and were assigned to either the intervention or a control group.During the 2 months intervention period,children in the test group were trained on proper hand hygiene practices and techniques with the aid of the interactive android-based tablets.The numbers of absent days of all the children were recorded for 2 months before the intervention and during the intervention.Results In the test group,there was a 25%increase in the total number of absent days from the pre-intervention period to the intervention period,a much lesser increment observed as compared to that of control group in which the increase was much higher at 89%.Results showed a significant difference(P<0·05)between the absenteeism rates for the test and control group during the intervention period.Conclusion These results suggest that proper education and intervention increase hand hygiene compliance,which may help decrease school absenteeism due to illness;however,a longer study duration may be necessary to evaluate the benefit further.

关键词： Absenteeism Hand hygiene povidone-iodine Pre-school children

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povidone-iodine(beta碘)在眼科手术中的应用

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中国实用眼科杂志 1999年第12期17卷 759-760页

作者：张良余柏儒苏敏奇尹东明何志明广东省人民医院!510080

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A clinical trial of premedication for unscheduled laser in situ keratomileusis surgeries and a related bacteriological analysis of conjunctival sacs

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Chinese Medical Journal 2014年第20期127卷 3669-3671页

作者： Yin Yi Zhao Lu Wang Xiaolei Wang Yanling Department of Ophthalmology Beijing Friendship Hospital CapitalMedical University Beijing 100050 China

Laser in situ keratomileusis （LASIK） is a quick and effective approach for treating ametropia. It is used to treat relatively healthy corneas, and patients usually have high expectations and requirements for postoperative visual results. Therefore, the prevention of severe postoperative complications, such as corneal infections, is important.~ In China, some individuals require a rapid improvement in uncorrected visual acuity through surgery. There are also individuals from other cities seeking better medical services. Because of time limitations, the preoperative preparation time may be too short to complete a 3-day eye drop treatment with antibiotics. In this case study, we compared the bacterial eliminating effects and adverse reactions of levofloxacin eye drops （Santen Corp., Japan） and 0.5% povidone-iodine （PVI, Nanda Pharmaceutical Corp., China） irrigation, for different time periods before unscheduled LASIK surgery.

关键词： levofloxacin povidone-iodine bacteria laser in situ keratomileusis conjunctiva

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用碘化聚乙烯吡咯烷酮(povidone-iodine)持续冲洗治疗心脏手术后纵隔感染的经验

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国际心血管病杂志 1975年第6期 382-383页

作者：周思伯

作者从1971年9月至1974年3月,对430例成人和215例儿童,进行了胸骨正中切口的心脏体外循环手术,共有14例发生胸骨及纵隔感染,发生率为2.2%(成人组为1.6%,儿童组3.2%)。

关键词：纵隔感染手术持续冲洗抗菌素 povidone-iodine

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