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Implantable versatile oxidized bacterial cellulose membrane for postoperative HNSCC treatment via photothermal-boosted immunotherapy

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Nano Research 2023年第1期16卷 951-963页

作者： Jun-Jie Zhou Xiao-Hong Li Peng-Yu He Fu-Yu Qi Muhammad Wajid Ullah Shu-Jin Li Yuan-Tong Liu Lin-Lin Bu Guang Yang Zhi-Jun Sun The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral Maxillofacial Head Neck Oncology School&Hospital of StomatologyWuhan UniversityWuhan 430079China Key Laboratory of Artificial Micro-and Nano-Structures of Ministry of Education School of Physics and Technology Wuhan UniversityWuhan 430079China Department of Biomedical Engineering College of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Biofuels Institute School of the Environment and Safety EngineeringJiangsu UniversityZhenjiang 212013China

The recurrence of head and neck squamous cell carcinoma(HNSCC)after surgical resection continues to pose a major challenge to cancer treatment.Advanced HNSCC exhibits a low response rate to immune checkpoint blockade(ICB),while photothermal therapy(PTT)can increase the infiltration of immune cells to make tumors more susceptible to cancer immunotherapy.In this regard,we designed and constructed a novel multifunctional nanocomposite comprised of oxidized bacterial cellulose(OBC),thrombin(TB),and gold nanocages(AuNCs)containing anti-programmed death 1(PD-1)antibody(αPD-1@AuNCs),which allows the combination of therapies with remarkable postoperative antitumor immunity to control local tumor recurrence.TheαPD-1@AuNCs displayed high light-to-heat conversion efficiency and induced pyroptosis under near infrared(NIR)irradiation,which activated a potent antitumor immune response.More importantly,the therapeutic system could induce tumor pyroptosis and enhance antitumor immune response by increasing T-cell infiltration and reducing the immune suppressive cells,when combined with local ICB therapy,which effectively avoided the tumor recurrence in a HNSCC postoperative mice model.Overall,the newly developed multifunctional nanocomposites could be a promising candidate for the treatment of postoperative HNSCC.

关键词： head and neck squamous cell carcinoma(HNSCC) oxidized bacterial cellulose pyroptosis immunotherapy Postoperative treatment

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Clinical Observation of Chinese Medicinal Prescriptions for Swelling and Pain in The Postoperative treatment of Mixed Hemorrhoids

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Journal of Clinical and Nursing Research 2024年第3期8卷 101-107页

作者： Yuru Duan Guangliang Xu Lei Ge Wei Zhang Xu Zhang Yi Yang Hospital of Traditional Chinese Medicine of Qiqihar Qiqihar 161005Heilongjiang ProvinceChina

Objective:To observe the clinical effect of traditional Chinese medicine(TCM)on reducing swelling and pain in patients with mixed hemorrhoids.Methods:Sixty patients with mixed hemorrhoids who were admitted to the Hospital of Traditional Chinese Medicine of Qiqihar from January 2023 to January 2024 were selected and divided into two groups.The treatment group(n=30)was treated with mixed hemorrhoid ligation combined with traditional Chinese swelling and pain medicine,and the control group(n=30)was only treated with mixed hemorrhoid ligation.The pain level,edema score,and prognosis of the two groups after the intervention were analyzed.The clinical efficacy was used as the evaluation criterion to compare the clinical effects of different treatment options.Results:After the treatment,the pain score,edema score,and prognostic wound score of the treatment group were all lower than those of the control group(P 0.05).The total clinical effectiveness of the treatment group(100%)was higher than that of the control group(76.67%),(χ^(2)=4.2857,P<0.05).Conclusion:The application of traditional Chinese swelling and pain medicine in treating patients with mixed hemorrhoids effectively reduced the patient’s pain,reduced the degree of wound edema,promoted wound healing,and improved the patient’s prognosis.The curative effect was significant and had a positive impact.

关键词： Chinese herbal prescriptions for reducing swelling and pain Mixed hemorrhoids Postoperative treatment

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Immunogenic hydrogel toolkit disturbing residual tumor “seeds” and pre-metastatic “soil” for inhibition of postoperative tumor recurrence and metastasis

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Acta Pharmaceutica Sinica B 2022年第8期12卷 3383-3397页

作者： Minglu Zhou Qingting Zuo Yuan Huang Lian Li Key Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry and Sichuan Province Sichuan Engineering Laboratory for Plant-Sourced Drug and Sichuan Research Center for Drug Precision Industrial TechnologyWest China School of PharmacySichuan UniversityChengdu 610041China

Tumor recurrence and metastasis is the leading cause of mortality for postoperative breast cancer patients. However, chemotherapy intervention after surgery is often unsatisfactory, because residual microtumors are difficult to target and require frequent administration. Here, an all-in-one and oncefor-all drug depot based on in situ-formed hydrogel was applied to fit the irregular surgical trauma, and enable direct contact with residual tumors and sustained drug release. Our immunological analysis after resection of orthotopic breast tumor revealed that postsurgical activation of CXCR4-CXCL12 signal exacerbated the immunosuppression and correlated with adaptive upregulation of PD-L1 in recurrent tumors. Thus, a multifunctional hydrogel toolkit was developed integrating strategies of CXCR4 inhibition,immunogenicity activation and PD-L1 blockade. Our results showed that the hydrogel toolkit not only exerted local effect on inhibiting residual tumor cell “seeds” but also resulted in abscopal effect on disturbing pre-metastatic “soil”. Furthermore, vaccine-like effect and durable antitumor memory were generated, which resisted a secondary tumor rechallenge in 100% cured mice. Strikingly, one single dose of such modality was able to eradicate recurrent tumors, completely prevent pulmonary metastasis and minimize off-target toxicity, thus providing an effective option for postoperative intervention.

关键词： Hydrogel Postoperative treatment Tumor recurrence Pre-metastatic niche CXCR4 inhibition Immunotherapy Local therapy Immunogenic cell death

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Chordoid meningioma： a retrospective study of 17 cases at a single institution

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Chinese Medical Journal 2013年第4期126卷 789-791页

作者： Zhu Hong-da Chen Hong Xie Qing Gong Ye Mao Ying Zhong Ping Che Xiao-ming Jiang Chen-chuan Huang Feng-ping Zheng Kang Li Shi-qi Gu Yu-xiang Bao Wei-ming Yang Bo-jie Wu Jin-song Wang Yin Xie Li-qian Zheng Ming-zhe Tang Hai-liang Wang Dai-jun Chen Xian-cheng Zhou Liang-fu Department of Neurosurgery Department of Neuropathology Huashan Hospital Fudan University Shanghai 200040 China

Chordoid meningioma （CM）, characterized by its resemblance to chordoma, was first described by Kepes et al＇ in 1988, and classified histologically as a WHO grade II neoplasm in the 2000 revision of the WHO grading system, featured by its aggressive clinical course, great risk of recurrence, and infrequent association with hematological conditions.2 This article describes the clinical course, radiological characteristics, Postoperative treatment, and prognosis of 17 patients with CM who underwent surgical treatment at our hospital.

关键词： chordoid meningioma outcomes Postoperative treatment

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Management and outcomes of surgical patients with intestinal Behçet’s disease and Crohn’s disease in southwest China

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World Journal of Clinical Cases 2021年第16期9卷 3858-3868页

作者： Li Zeng Wen-Jian Meng Zhong-Hui Wen Yi-Long Chen Yu-Fang Wang Cheng-Wei Tang Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Gastrointestinal Surgery West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China Biomedical Big Data Center West China Hospital/West China School of MedicineSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Gastrointestinal involvement in Behçet's disease(GIBD)and Crohn’s disease(CD)are inflammatory diseases sharing a considerable number of similarities.However,different from CD,the operative and postoperative management of GIBD remains largely empirical because of the lack of comprehensive treatment guidelines.AIM To compare surgical patients with GIBD and those with CD in a medical center and identify notable clinical features and effective Postoperative treatment for surgical patients with GIBD.METHODS We searched patients diagnosed with CD and GIBD who underwent operations for gastrointestinal complications from 2009 to 2015 at West China Hospital of Sichuan University.A total of 10 surgical patients with GIBD and 106 surgical patients with CD were recruited.Information including demographic data,medication,and operative and postoperative parameters were collected and analyzed.As the incidence of surgical GIBD is low,their detailed medical records were reviewed and compared to previous studies.Moreover,the prognoses of CD and GIBD were evaluated respectively between groups treated with biological and non-biological agents.RESULTS Indication for first surgery was often acute intestinal perforation for GIBDpatients (7/10 vs 0/106, P postoperative complications, 50% of patients with GIBD and 38.7%of patients with CD had recurrence postoperatively, and 40% (4/10) of patientswith GIBD and 26.4% (28/106) of patients with CD underwent reoperations. Theaverage period of postoperative recurrence was 7.87 mo in patients with Behçet'sdisease (BD) and 10.43 mo in patients with CD, whereas the mean duration fromfirst surgery to reoperation was 5.75 mo in BD patients and 18.04 mo in CDpatients. Surgical patients with GIBD more often used corticosteroids (6/10 vs7/106, P < 0.001) and thalidom

关键词： Gastrointestinal involvement in Behçet's disease Crohn’s disease Surgery Postoperative treatment Biological agents Real-world study

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