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Peri-implant gas accumulation in response to magnesium-based musculoskeletal biomaterials:Reframing current evidence for preclinical research and clinical evaluation

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Journal of Magnesium and Alloys 2024年第1期12卷 59-71页

作者： Yu Sun Heike Helmholz Regine Willumeit-Römer Institute of Metallic Biomaterials Helmholtz-Zentrum HereonMax-Planck-Str.1Geesthacht 21502Germany

Historically,the rapid degradation and massive gas release from magnesium(Mg)implants resulted in severe emphysema and mechanical *** the advent of new alloys and surface treatment methods,optimized Mg implants have re-entered clinics since last decade with reliable ***,the optimization aims at slowing down the degradation process,rather than exemption of the gas *** study involved a systematic evaluation of current preclinical and clinical evidence,regarding the physical signs,symptoms,radiological features,pathological findings and complications potentially associated with peri±implant gas accumulation(PIGA)after musculoskeletal Mg *** literature search identified 196 potentially relevant publications,and 51 papers were enrolled for further analysis,including 22 preclinical tests and 29 clinical studies published from 2005 to *** Mg-based materials have been evaluated in animal research,and the application of pure Mg and Mg alloys have been reported in clinical follow-ups involving multiple anatomical sites and musculoskeletal *** tissue and intraosseous PIGA are common in both animal tests and clinical follow-ups,and potentially associated with certain adverse *** examinations especially micro-CT and clinical CT scans provide valuable information for quantitative and longitudinal *** according to simulation tests involving Mg implantation and chemical processing,tissue fixation could lead to an increase in the volume of gas cavity,thus the results obtained from ex vivo imaging or histopathological evaluations should be interpreted with *** still lacks standardized procedures or consensus for both preclinical and clinical evaluation of ***,by providing focused insights into the topic,this evidence-based study will facilitate future animal tests and clinical evaluations,and support developing biocompatible Mg implants for the treatment of musculoskeletal

关键词： Magnesium implant Degradation Hydrogen Gas release postoperative follow-up

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Emergence of bariatric psychiatry as a new subspecialty

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World Journal of Psychiatry 2022年第1期12卷 108-116页

作者： Alfonso Troisi Department of Systems Medicine University of Rome Tor VergataRome 00133Italy

Bariatric surgery is the branch of surgery aimed at helping a person with obesity lose *** implementation of surgical treatment of obesity is growing at an impressive *** expected,the expanding implementation of bariatric procedures has progres-sively revealed critical issues that were not evident when the number of obese patients treated with surgery was relatively *** critical issue is the importance of mental health assessment and care of bariatric *** aim of this review is to provide readers with an up-to-date summary of the goals,methods,and clinical strategies of bariatric *** aims can be grouped into three distinct ***,to ascertain that there are no psychiatric contraindications to safe bariatric ***,to diagnose and treat pre-surgery mental conditions that could predict poor weight ***,to diagnose and treat post-surgery mental conditions associated with poor quality of *** bariatric psychiatry has gained the status of a new subspecialty within the field of mental health and psychopathology,many clinical questions remain *** need more long-term data on outcome measures such as quality of life,adherence to behavioral guidelines,risk of suicide,and postsurgery prevalence of psychological disturbances and mental disorders.

关键词： Bariatric surgery Psychiatry Weight loss Mental health Quality of life Preoperative assessment postoperative follow-up

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Clear cell sarcoma metastasizing to the pancreas

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World Journal of Clinical Cases 2024年第17期12卷 2928-2931页

作者： Meer M Chisthi Department of General Surgery Government Medical College PathanamthittaKonni 689691KeralaIndia

In this editorial based on a case report,we delve into a seldom-seen occurrence of clear cell sarcoma featuring pancreatic metastasis in a 47-year-old male *** for its typical tendency to metastasize to the lungs,bones,and brain,clear cell sarcoma rarely extends its reach to the *** the initial absence of discernible abnormalities during the patient's physical examination,the manifestation of abdominal pain prompted further *** abdominal computed tomography brought to light the presence of a pancreatic tumor,culminating in the definitive diagnosis of clear cell sarcoma with pancreatic *** successful management of this atypical presentation involved a series of surgical interventions,including distal pancreatectomy and *** report not only sheds light on the infrequent manifestation of clear cell sarcoma within the pancreas but also underscores the pivotal role of vigilant postoperative follow-up in addressing this rare *** emphasis on postoperative care serves as a crucial aspect of the broader narrative,acknowledging the need for ongoing monitoring and management to ensure a comprehensive and successful treatment trajectory for patients with this unique presentation of clear cell sarcoma.

关键词： Clear cell sarcoma Pancreatic metastasis Soft tissue sarcoma Surgical interventions postoperative follow-up

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Primary Hyperparathyroidism Revealed by Impaired Renal Function with Persistent Elevation of Parathormon (PTH) and Normal Calcemia after Surgical Removal of the Parathyroid Adenoma

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Open Journal of Endocrine and Metabolic Diseases 2023年第2期13卷 39-44页

作者： Yao Assita Lecadou Jocelyne Maman Salahoudine N’guessan Anselme Danho Jocelyne Kouassi Frank Hué Adélaïde Koffi Dago Pierre Abodo Jacko Endocrinology Diabetology Department CHU Yopougon Abidjan Ivory Coast

Introduction: The curative management of primary hyperparathyroidism is based on surgery. We report the case of a patient presenting with elevated parathormone despite surgical removal of the parathyroid adenoma. Observation: A 48-year-old patient presented for more than 6 months with significant weight loss, polyuria with polydipsia and impaired renal function. The assessment carried out revealed hypercalcaemia at 155 mg/L with hypophastetaemia at 24 mg/L and an elevation of the parathyroid hormone at 218.9 pg/ml. Cervical ultrasound showed a mass at the expense of the lower left parathyroid gland. These results made it possible to conclude primary hyperparathyroidism by parathyroid adenoma which was supported surgically. The postoperative biological assessment revealed a normocalcemia at 85 mg/L associated with an increase in parathormone (PTH) at 271.9 pg/ml. In front of the normalization of calcemia in the subsequent controls and the amendment of all the signs, monitoring was carried out. 9 months after surgery, spontaneous normalization of PTH was observed at 38.4 pg/ml with normal serum calcium at 90 mg/l. Discussion: Primary hyperparathyroidism can be revealed by other manifestations. Post-operative follow-up is generally simple with normalization of PTH and serum calcium. However, there may persist an elevation of PTH with normal self-limiting calcemia.

关键词： Primary Hyperparathyroidism postoperative follow-up Normocalcemic Hyperparathormonemia

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