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A Study Exploring the Neuronal Activity in Primary Motor cortex and posterior parietal cortex when Monkey Performing a Target Pursuing and Grasping Task

A Study Exploring the Neuronal Activity in Primary Motor Cor...

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中国神经科学学会第十二届全国学术会议

作者： Hong-Ji SUN Xuan MA Peng ZHANG Yi-Ran LANG Jin-Xu MA Jun DAI Jin ZHOU Chang-Yong WANG Department of Advanced Interdisciplinary Studies Institute of Basic Medical Sciences and Tissue Engineering Research Center Academy of Military Medical Sciences School of Life and Technology Harbin Institute of Technology College of Automation Huazhong University of Science and Technology

Objective The performing of dexterous reaching and grasping movements with arm and hand requires the participation of multiple brain areas. In previous studies, researchers have tried to investigate the moving related neuronal activity with in-vivo electrophysiology recordings on monkeys, and found neuronal ensembles tuned to target location, moving velocity or grasping gestures. However, most of them have just focused on single brain area. In this study, we aim to explore the neuronal activity in both M1 and posterior parietal cortex(PPC) simultaneously on awake behaving monkeys. Methods We trained two monkeys to perform a novel reach-to-grasp task with a moving target. With a special designed apparatus, the monkey must finish serial movements before liquid reward. The parameters set for baseline and grasping period are 500 ms and 200 ms separately. Three and four microelectrode arrays were inserted into two monkeys separately. Neural signals were collected with an Omni Plex-128 system. And spikes were detected with a threshold crossing paradigm and single units were isolated using a principle component analysis(PCA) based method for each channel. Firing rates were calculated from spike counts in non-overlapping sliding windows. Results(1) Compared with baseline, we find modulated neurons of different percentages related other movement stages;(2) Among modulated neurons, several neurons show tuning pattern for certain parameters such as direction. Conclusion From the results, it indicates that neurons in posterior parietal cortex and primary motor cortex show different tuning patterns for reaching and grasping a moving target.

关键词： motor cortex posterior parietal cortex monkey brain machine interface

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Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor cortex during Movement Preparation

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Neuroscience Bulletin 2019年第5期35卷 826-840页

作者： Hongji Sun Xuan Ma Liya Tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou Changyong Wang School of Life Science and Technology Harbin Institute of Technology 92 West Dazhi Street Nan Gang District Harbin 150080 China Department of Neural Engineering and Biological Interdisciplinary Studies Institute of Military Cognition and Brain Sciences Academy of Military Medical Sciences 27 Taiping Rd Beijing 100850 China Department of Neurology Chinese PLA General Hospital Beijing 100853 China

Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) ***, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention.

关键词： Macaque Primary motor cortex Primary somatosensory cortex posterior parietal cortex Temporal perception Local field potentials

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