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miR-34b-3p Inhibition of eIF4E Causes post-stroke depression in Adult Mice

Neuroscience Bulletin 2023年第2期39卷 194-212页

作者： Xiao Ke Manfei Deng Zhuoze Wu Hongyan Yu Dian Yu Hao Li Youming Lu Kai Shu Lei Pei Department of Neurobiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China The Institute for Brain Research Collaborative Innovation Center for Brain ScienceHuazhong University of Science and TechnologyWuhan 430030China Department of Pathophysiology Basic Medical SchoolNorth Sichuan Medical CollegeNanchong 637100China Department of Physiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

post-stroke depression(PSD)is a serious and common complication of stroke,which seriously afects the rehabilitation of stroke patients.To date,the pathogenesis of PSD is unclear and efective treatments remain unavailable.Here,we established a mouse model of PSD through photothrombosis-induced focal ischemia.By using a combination of brain imaging,transcriptome sequencing,and bioinformatics analysis,we found that the hippocampus of PSD mice had a signifcantly lower metabolic level than other brain regions.RNA sequencing revealed a signifcant reduction of miR34b-3p,which was expressed in hippocampal neurons and inhibited the translation of eukaryotic translation initiation factor 4E(eIF4E).Furthermore,silencing eIF4E inactivated microglia,inhibited neuroinfammation,and abolished the depression-like behaviors in PSD mice.Together,our data demonstrated that insufcient miR34b-3p after stroke cannot inhibit eIF4E translation,which causes PSD by the activation of microglia in the hippocampus.Therefore,miR34b-3p and eIF4E may serve as potential therapeutic targets for the treatment of PSD.

关键词： post-stroke depression Hippocampus miRNA Microglia Neuroinfammation

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Management of post-stroke depression(PSD)by electroencephalography for effective rehabilitation

再生工程(英文)

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再生工程(英文) 2023年第1期4卷 44-54页

作者： Bibo Yang Yanhuan Huang Zengyong Li Xiaoling Hu Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina Beijing Key Laboratory of Rehabilitation Technical Aids for Old‐Age Disability National Research Centre for Rehabilitation Technical Aids BeijingBeijingChina University Research Facility in Behavioral and Systems Neuroscience(UBSN) The Hong Kong Polytechnic UniversityHong KongChina The Hong Kong Polytechnic University Shenzhen Research Institute ShenzhenChina Research Institute for Smart Ageing(RISA) The Hong Kong Polytechnic UniversityHong KongChina

post-stroke depression(PSD)has negative impacts on the daily life of stroke survivors and delays their neuro-logical recovery.However,traditional post-stroke rehabilitation mainly focused on motor restoration,whereas little attention was given to the affective deficits.Effective management of PSD,including diagnosis,intervention,and follow-ups,is essential for post-stroke rehabilitation.As an objective measurement of the nervous system,electroencephalography(EEG)has been applied to the diagnosis and evaluation of PSD.In this paper,we re-viewed the literature most related to the clinical applications of EEG for PSD and offered a cross-section that is useful for selecting appropriate approaches in practice.This study aimed to gather EEG-based empirical ev-idence for PSD diagnosis,review interventions for managing PSD,and analyze the evaluation approaches.In total,33 diagnostic studies and 19 intervention studies related to PSD and depression were selected from the literature.It was found that the EEG features analyzed by both band-based and nonlinear dynamic approaches were capable of quantifying the abnormal neural responses on the cortical level for PSD diagnosis and interven-tion evaluation/prediction.Meanwhile,EEG-based machine learning has also been applied to the diagnosis and evaluation of depression to automate and speed up the process,and the results have been promising.Although brain-computer interface(BCI)interventions have been widely applied to post-stroke motor rehabilitation and cognitive training,BCI emotional training has not been directly used in PSD yet.This review showed the need for understanding the cortical responses of PSD to improve its diagnosis and precision treatment.It also revealed that future post-stroke rehabilitation plans should include training sessions for motor,affect,and cognitive functions and closely monitor their improvements.

关键词： post-stroke depression stroke rehabilitation Electroencephalography Machine learning Brain-computer interface

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miR-137, a new target for post-stroke depression?

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Neural Regeneration Research 2013年第26期8卷 2441-2448页

作者： Lixia Zhao Huazi Li Ruiyou Guo Teng Ma Rongyao Hou Xiaowei Ma Yifeng Du Department of Neurology Shandong Provincial Hospital Department of Neurology Haici Hospital Affiliated to Medical College of Qingdao University Department of Medical Imaging Haici Hospital Affiliated to Medical College of Qingdao University

Expression of miR-137 is downregulated in brain tissue from patients with depression and suicidal behavior, and is also downregulated in peripheral blood from stroke patients. However, it is not yet known if miR-137 acts as a bridge between stroke and depression. To test this, we used middle cerebral artery occlusion and chronic mild stress to establish a post-stroke depression model in rats. Compared with controls, we found significantly lower miR-137 levels in the brain and peripheral blood from post-stroke depression rats. Injection of a miR-137 antagonist into the brain ventricles upregulated miR-137 levels, and improved behavioral changes in post-stroke depression rats. Luciferase assays showed miR-137 bound to the 3＇UTR of Grin2A, regulating Grin2A expression in a neuronal cell line. Grin2A gene overexpression in the brain of post-stroke depression rats, no- ticeably suppressed the inhibitory effect of miR-137 on post-stroke depression. Overall, our results show that miR-137 suppresses Grin2A protein expression through binding to Grin2A mRNA, thereby exerting an inhibitory effect on post-stroke depression. Our results offer a new therapeutic direction for post-stroke depression.

关键词： neural regeneration brain injury post-stroke depression microRNA cerebrovascular disease Grin2A miR-137 neuroregeneration

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Apolipoprotein E polymorphisms increase the risk of post-stroke depression

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Neural Regeneration Research 2016年第11期11卷 1790-1796页

作者： Xue-bin Li Jie Wang An-ding Xu Jian-min Huang Lan-qing Meng Rui-ya Huang Jun-li Wang stroke Center & Neurology Division the First Affiliated Hospital of Jinan University Department of Nephrology the Affiliated Hospital of Youjiang Medical University for Nationalities Department of Neurology the Affiliated Hospital of Youjiang Medical University for Nationalities Department of Laboratory Medicines the Affiliated Hospital of Youjiang Medical University for Nationalities

Recent reports have shown that apolipoprotein E （APOE） polymorphisms are involved in neurodegenerative disease. However, it is unclear whether APOE affects post-stroke depression. Accordingly, we hypothesized that APOE polymorphisms modify the risk of post-stroke depression. Here, we performed a hospital-based case-control study （including 76 cerebral infarction cases with post-stroke depression, 88 cerebral infarction cases without post-stroke depression, and 109 controls without any evidence of post-stroke depression or cerebral infarction） to determine possible association between APOE rs429358 and rs7412 polymorphisms and risk of post-stroke depression. Our findings show no difference among the groups with regards genotype distribution of the rs7412 polymorphism. In contrast, APOE genotypes with rs429358-C alleles increased the risk of post-stroke depression. Further, the rs429358 polymorphism was associated with significantly decreased regional cerebral blood flow values in the left temporal lobe of post-stroke depression cases. Additionally, the rs429358 polymorphism was not only associated with depression severity, but with increasing serum levels of total cholesterol. These resuits suggest that the APOE rs429358 polymorphism is associated with increased risk of developing post-stroke depression, and that APOE rs429358-C allele genotypes may be detrimental to recovery of nerve function after stoke. Indeed, these findings provide clinical data for future post-stroke depression gene interventions.

关键词： nerve regeneration apolipoprotein E genetic polymorphism post-stroke depression risk regional resting-state cerebral blood flow rs429358 rs7412 cerebral infarction neural regeneration

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Metabolic changes of prefrontal cerebral lobe,white matter and cerebellum in patients with post-stroke depression A proton magnetic resonance spectroscopy study

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Neural Regeneration Research 2008年第2期3卷 142-147页

作者： Qinggang Xu Hong Cao Qingwei Song Jianlin Wu Department of Radiology First Affiliated Hospital of Dalian Medical University Dalian 116011 Liaoning Province China Department of Radiology Bering TongRen Hospital Capital Medical University Beijing 100730 China Department of Neurology First Affiliated Hospital of Dalian Medical University Dalian 116011 Liaoning Province China

BACKGROUND： Proton magnetic resonance spectroscopy （IH-MRS） non-invasively detects changes in chemical substances in the brain, which reflects the pathological metabolism.OBJECTIVE： To investigate changes in N-acetyl-aspartate （NAA）, choline （Cho）, creatine （Cr）, and myoinositol （MI） in the gray and white matter of cerebral prefrontal lobe and cerebellum of patients with differential degrees of post-stroke depression （PSD） using ^1H-MRS. DESIGN： A case control study. SETTING： The First Affiliated Hospital of the Dalian Medical University. PARTICIPANTS： A total of 38 patients with stroke （28 male and l0 female patients, aged 40 to 79 years） were selected from the Department of Neurology, 1st Affiliated Hospital, Dalian Medical University, from February to October in 2004. All subjects met the DSM-IV criteria for cerebrovascular disease and depression. The degree of depression was defined according to Hamilton criteria. 38 patients with PSD were divided into two groups according to the time after ischemia, 20 patients in the acute group with less than 10 days after ischemic attack （mild： 16 patients, moderate/severe： 4 patients） and 18 patients in the chronic group with more than l l days after ischemic attack （mild： 15 patients, moderate/severe： 3 patients）. Seventeen healthy volunteers with matching age from 41 to 80 years were examined as a control group. The study was approved by the Medical Ethics Committee of the University Medical Center Utrecht, and each participant signed an informed consent form. METHODS： Spectra were acquired by multi-voxel point-resolved spectroscopy （PRESS） sequence with GE signal.5T MR/i, localized in prefrontal cerebral lobe and cerebellum. Values of NAA, Cho, MI, and Cr ere compared between different graded PSD patients and control subjects with one-way analysis of variance in software SPSS 11.5. MAIN OUTCOME MEASURES： Metabolite concentration in different brain regions of interest. Difference in metabolites between distinctly graded PSD patients and control subjects. Ex

关键词： post-stroke depression proton magnetic resonance spectroscopy N-acetyl-aspartate creatine

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Electroacupuncture at the Wangu (GB 12) acupoint suppresses expression of inflammatory factors in the hippocampus and frontal lobe of rats with post-stroke depression

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Neural Regeneration Research 2011年第36期6卷 2839-2844页

作者： Rubo Sui Lei Zhang Department of Neurology First Affiliated Hospital of Liaoning Medical College Jinzhou 121001 Liaoning Province China Department of School of Nursing Liaoning Medical College Jinzhou 121001 Liaoning Province China

Electroacupuncture was performed at the Wangu （GB 12） acupoint, whose position is similar to the cerebellar fastigial nucleus in rats with post-stroke depression. Results showed that the expression of nuclear factor-κB and the levels of tumor necrosis factor-α and interleukin-1β decreased. Simultaneously, the extent of edema in the hippocampus and frontal lobe decreased, and the morphology of the nerve cells recovered to near normal. In addition, fluoxetine treatment displayed a similar effect on post-stroke depression as electroacupuncture at GB 12 acupoint. The results indicate that electroacupuncture at GB 12 acupoint can reduce the levels of cytokines in the hippocampus and frontal lobe of rats with post-stroke depression, and thus provide a neuroprotective effect on post-stroke depression.

关键词： post-stroke depression hippocampus frontal lobe cytokines electroacupuncture Wangu （GB 12） acupoint traditional Chinese medicine neural regeneration

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Progress of Traditional Chinese Medicine in the Treatment of post-stroke depression

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Medicinal Plant 2022年第3期13卷 92-95页

作者： Shanbei ZHONG Luchuan County Hospital of Traditional Chinese Medicine Luchuan 537700 China

The patients with post-stroke depression often form a negative evaluation of themselves,and even have the idea of suicide in serious cases.Therefore,post-stroke depression has become one of the most common complications of mental illness after stroke,which seriously hinders the normal rehabilitation of the central nervous system,thus increasing the disability rate,early recurrence rate and mortality rate of patients.Therefore,the active treatment of post-stroke depression is very necessary.Western medicine uses antidepressant drugs for this kind of patients,but because the side effects of antidepressants are relatively large,the compliance of patients is not good,it is not easy to see the effect,while traditional Chinese medicine(TCM)has many ways to deal with post-stroke depression with obvious advantages,the side effects are relatively small,and there is more compliance in patients.This paper focuses on several TCM treatment methods,hoping to provide a reference for the treatment of post-stroke depression.

关键词： post-stroke depression TCM treatment Clinical progress

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Clinical Study of Acupuncture Combined with Emotional Intervention in Patients with post-stroke depression

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Journal of Clinical and Nursing Research 2023年第4期7卷 133-138页

作者： Fajin Wang Yanyan Huang Zhidan Zhang Yanhong Yang Huikai Wang Hao Han Yongsheng Zhang Yuxiang Jiao Jianyong Gao Binzhou Hospital of Traditional Chinese Medicine Binzhou 256600Shandong ProvinceChina

Objective:To investigate the clinical efficacy of acupuncture combined with emotional intervention in patients with post-stroke depression(PSD).Methods:A total of 100 patients with PSD who met the inclusion criteria were randomly divided into an experimental group(50 cases)and a control group(50 cases)using the random number table method,and the enrollment was in order of admission time.The control group used conventional treatment of oral antidepressant Deanxit tablets(0.5 mg flupenthixol+10 mg melitracen)with the dose appropriately adjusted according to the patient’s medication effect,and modern rehabilitation treatment given selectively according to the patient’s condition.The experimental group had similar treatment as the control group with the addition of traditional Chinese medicine(TCM)acupuncture combined with emotional intervention.The application effects of both groups before and after treatment were verified using the Hamilton depression Rating Scale(Ham-D),National Institutes of Health stroke Scale(NIHSS),and Activities of Daily Living(ADL),serotonin levels were measured,and statistical analyses were carried out.Results:The total effective rate of patients in the experimental group was significantly higher than that in the control group,and the Ham-D score,NIHSS score,ADL score,and serotonin level after treatment were significantly higher than those in the control group,and the difference between the two groups was statistically significant(P<0.05).Conclusion:For patients with PSD,adding TCM acupuncture with emotional intervention on top of conventional treatment significantly improve the clinical efficacy and better improve the daily life ability of patients.

关键词： post-stroke depression Emotional intervention Acupuncture Conventional treatment

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Research progress on pharmacological effect of Salvianolic acid for injection in post-stroke depression

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Journal of Hainan Medical University 2020年第10期26卷 69-72页

作者： Wen Gu Li Wang The Second Hospital of Shanxi Medical University

post-stroke depression (PSD) is one of the most common affective disorders after acute cerebrovascular injury. It significantly increases the mortality, disability rate and recurrence rate of stroke, which places a heavy burden on families and society. The etiology of PSD is not yet clear, involving a series of complex mechanisms. Inflammatory response, apoptosis, neurotrophic factors, neurotransmitters and many others may play important roles, and there is no effective treatment. Salvianolic acid for injection (SAFI) has the functions of anti-inflammatory, anti-oxidative stress, anti-apoptotic and can improve depressive behavior. It is expected to become a new antidepressant for the treatment of PSD.

关键词： Salvianolic acid for injection Inflammatory response Brain-derived neurotrophic factor Apoptosis stroke post-stroke depression

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Research Progress in the Pathogenesis of post-stroke depression

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Journal of Clinical and Nursing Research 2021年第2期5卷 77-79页

作者： Weiwei He Yongmei Yan Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina Affiliated Hospital of Shaanxi University of Chinese Medicine Xianyang 712046Shaanxi ProvinceChina

post-stroke depression is an affective disorder that occurs after stroke.Its pathogenesis has not yet been fully understood,and it mainly involves neurobiology,neuroanatomy,and psychology.This paper provides an overview on the neurobiological mechanism of post-stroke depression to further understand post-stroke depression and to provide references for further research.

关键词： post-stroke depression Neurotransmitter Neuroanatomy euroimmunity Cytokines Neuroplasticity

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