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Key factors in developing the trinitrobenzene sulfonic acid-induced post-inflammatory irritable bowel syndrome model in rats

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World Journal of Gastroenterology 2012年第20期18卷 2481-2492页

作者： Hong-Yan Qin Hai-Tao Xiao Justin CY Wu Brian M Berman Joseph JY Sung Zhao-Xiang Bian School of Chinese Medicine Hong Kong Baptist University Hong Kong 999077 China Faculty of Medicine The Chinese University of Hong Kong.Hong Kong 999077 China Center for Integrative Medicine University of Maryland School of Medicine Baltimore MD 21201 United States

AIM:To investigate the key factors in developing the trinitrobenzene sulfonic acid(TNBS)-induced postinflammatory irritable bowel syndrome(PI-IBS)model in rats. METHODS:TNBS was administered to rats at the following conditions:(1)with different doses(20,10,5 mg/0.8 mL per rat);(2)with same dose in different concentrations(20 mg/rat,25,50 mg/mL);(3)in different ethanol percentage(25%,50%);and(4)at depth either 4 cm or 8 cm from *** 5 d and 4 wk after TNBS administration,inflammation severity and inflammation resolution were *** 4 and 8 wk after TNBS application,visceral hyperalgesia and enterochromaffin(EC)cell hyperplasia were assayed by abdominal withdrawal reflex test,silver staining and capillary electrophoresis. RESULTS:Our results showed that:(1)TNBS induced dose-dependent acute inflammation and inflammation *** 5 d post TNBS,the pathological score and myeloperoxidase(MPO)activity in all TNBS treated rats were significantly elevated compared to that of the control(9.48±1.86,8.18±0.67,5.78± 0.77 vs 0,and 3.55±1.11,1.80±0.82,0.97±0.08 unit/mg vs 0.14±0.01 unit/mg,Ppost TNBS,the pathological score in high and median dose TNBS-treated rats were still significantly higher than that of the control(1.52±0.38 and 0.80±0.35 vs 0,Ppost TNBS,abdominal withdrawal reflex (AWR)threshold pressure in all TNBS-treated groups were decreased compared to that of the control(21.52 ±1.73 and 27.10±1.94 mmHg vs 34.44±1.89 mmHg,Ppost TNBS,AWR threshold pressure in 8 cm administration group was still significantly decreased(23.33±1.33 mmHg vs 36.79±2.29 mmHg,P<0.05);(3)Ethanol percentage affected the TNBS-induced inflammation severity and visceral *** TNBS-25%ethanol-treated group,the pathological score and MPO activity were significantly lowered compared to that of the TNBS-50%ethanoltreated group,while AWR thres

关键词： post-inflammatory Irritable bowel syndrome Rat model Trinitrobenzene sulfonic acid Key factors

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Dramatic Improvement of Long Lasting post-inflammatory Hyperpigmentation by Oral and Topical Tranexamic Acid

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Journal of Cosmetics, Dermatological Sciences and Applications 2012年第2期2卷 62-63页

作者： Jae Kyung Kim Sung Eun Chang Chong Hyun Won Mi Woo Lee Jee Ho Choi Kee Chan Moon Department of Dermatology Asan Medical Center University of Ulsan College of Medicine Seoul Korea

post-inflammatory hyperpigmentation is common problem, but its treatment still remains challenging. Tranexamic acid has been used to treat or prevent excessive bleeding loss in various medical conditions. There have been some reports of the effect of oral and topical tranexamic acid for treatment of pigmented disorder. Herein we report on a case of female patient who showed improvement of PIH after oral and topical tranexamic acid administration.

关键词： post-inflammatory Hyperpigmentation Tranexamic Acid

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Camouflage Therapy for post-inflammatory Hyperpigmentation on the Face Caused by Fixed Drug Eruption

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Journal of Cosmetics, Dermatological Sciences and Applications 2013年第3期3卷 8-10页

作者： Tomoko Kayama Hiroko Fujii Miki Tanioka Yoshiki Miyachi Department of Dermatology Kyoto University Graduate School of Medicine Kyoto Japan

Camouflage therapy has been used for permanent contour and pigmentary defects including telangiectasias, vitiligo, lentigines, nevi, atrophic scars and burn scars. The goal of the therapy is to provide new and innovative ways to normalize the appearance of patients with abnormalities. A variety of cosmetic techniques are used to assist these patients in making their irregularities as inconspicuous as possible. post-inflammatory hyperpigmentation is a frustrating problem afflicting many dermatology patients, particularly on the face. Here we report a case of successful cosmetic camouflage using the theory of complementary colors of light in a patient with post-inflammatory hyperpigmentation of the face caused by fixed drug eruption. Our case report supports the idea that camouflage for patients with post-inflammatory hyperpigmentation on the face caused by fixed drug eruption improves their quality of life and also supports the idea that camouflage should be part of the after care for patients who have received patch testing.

关键词： Cosmetic Camouflage post-inflammatory Hyperpigmentation Complementary Colors

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Rare case of an abdominal mass: Reactive nodular fibrous pseudotumor of the stomach encroaching on multiple abdominal organs

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World Journal of Clinical Cases 2014年第4期2卷 111-119页

作者： Xiao-Jiang Yi Chuang-Qi Chen Yin Li Jin-Ping Ma Zhi-Xun Li Shi-Rong Cai Yu-Long He Department of Gastrointestinal Surgery and Colorectal Surgery the First Affiliated Hospital Sun Yat-Sen University Department of Pathology the First Affiliated Hospital Sun Yat-Sen University

Reactive nodular fibrous pseudotumor(RNFP), which presents abdominal clinical manifestations and malignant radiographic results, usually requires radical resection as the treatment. However, RNFP has been recently described as an extremely rare benign postinflammatory lesion of a reactive nature, which typically arises from the sub-serosal layer of the digestive tract or within the surrounding mesentery in association with local injury or inflammation. In addition, a postoperative diagnosis is necessary to differentiate it from the other reactive processes of the abdomen. Furthermore, RNFP shows a good prognosis without signs of recurrence or metastasis. A 16-year-old girl presented with a 3-mo history of epigastric discomfort, and auxiliary examinations suggested a malignant tumor originating from the stomach; postoperative pathology confirmed RNFP, and after a 2-year follow-up period, the patient did not display any signs of recurrence. This case highlights the importance of preoperative pathology for surgeons who may encounter similar cases.

关键词： Reactive nodular fibrous pseudotumor post-inflammatory lesion Digestive tract Mesentery Good prognosis

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