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Exploring the interconnectivity of biomimetic hierarchical porous mg scaffolds for bone tissue engineering:Effects of pore size distribution on mechanical properties,degradation behavior and cell migration ability

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Journal of Magnesium and Alloys 2021年第6期9卷 1954-1966页

作者： Gaozhi Jia Hua Huang Jialin Niu Chenxin Chen Jian Weng Fei Yu Deli Wang Bin Kang Tianbing Wang Guangyin Yuan Hui Zeng Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen 518036China National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aircraft Technology Research Institute of COMACBeijing 102211China National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen 518036China Department of Orthopaedics Peking University People's HospitalBeijing 100044China

Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration,blood vessels invasion and transport of nutrient and ***,efforts and understanding of the interconnectivity of porous mg is limited due to the diverse architectures of pore struts and pore size distribution of mg scaffold *** this work,biomimetic hierarchical porous mg scaffolds with tailored interconnectivity as well as pore size distribution were prepared by template replication of infiltration *** scaffold with better interconnectivity showed lower mechanical *** interconnected pores would enhance the interconnectivity of the whole scaffold and reduce the change of ion concentration,pH value and osmolality of the degradation microenvironment due to the lower specific surface ***,the degradation rates of five tested mg scaffolds were no different because of the same geometry of strut *** cell culture and evaluation of cell density at both sides of four typical mg scaffolds indicated that cell migration through hierarchical porous mg scaffolds could be enhanced by not only bigger interconnected pore size but also larger main pore *** summary,design of interconnectivity in terms of pore size distribution could regulate mechanical strength,microenvironment in cell culture condition and cell migration potential,and beyond that it shows great potential for personalized therapy which could facilitate the regeneration process.

关键词： Bone tissue engineering porous mg scaffold Interconnectivity Pore size distribution Cell migration

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Effects of dynamic flow rates on degradation deposition behavior of mg scaffold

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Journal of Magnesium and Alloys 2023年第6期11卷 2054-2060页

作者： Gaozhi Jia Meng Zhou Yicong Huang Chenxin Chen Liang Jin Qian Wu Jian Weng Fei Yu Ao Xiong Guangyin Yuan Frank Feyerabend Hui Zeng Department of Bone&Joint Surgery Peking University Shenzhen HospitalShenzhen Peking University-The Hong Kong University of Science and Technology Medical CenterShenzhen Institute of Information TechnologyShenzhen 518036China National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China Beijing Key Laboratory of Civil Aircraft Structures and Composite Materials Beijing Aircraft Technology Research Institute of COMACBeijing 102211China College of Life Science Zhejiang Chinese Medical UniversityHangzhou 310053China Shenzhen Branch Guangdong Laboratory of Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of Agriculture and Rural AffairsAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Department of Orthopaedics Peking University People’s HospitalBeijing 100044China Division of Metallic Biomaterials Institute of Materials ResearchHelmholtz-Zentrum HereonGeesthacht 21502Germany National&Local Joint Engineering Research Center of Orthopaedic Biomaterials Peking University Shenzhen HospitalShenzhen 518036China

Degradability of bone tissue engineering scaffold that matching the regeneration rate could allow a complete replacement of host ***,the porous structure of biodegradable mg scaffolds certainly generated high specific surface area,and the three-dimensional interconnected pores provided fast pervasive invasion entrance for the corrosive medium,rising concern of the structural integrity during the *** clarify the structural evolution of the three-dimensional(3D)porous structure,semi-static immersion tests were carried out to evaluate the degradation performance in our previous ***,dynamic immersion tests mimicking the in vivo circulatory fluid through the interconnected porous structure have yet been ***,the effects of dynamic flow rates on the degradation deposition behavior of 3D porous mg scaffolds were rarely *** this study,mg scaffolds degraded at three flow rates exhibited different degradation rates and deposition process.A flow rate of 0.5 m L/min introduced maximum drop of porosity by accumulated deposition *** deposition products provided limited protection against the degradation process at a flow rate of 1.0 m L/*** three-dimensional interconnected porous structure of mg scaffold degraded at 2.0 m L/min well retained after 14 days showing the best interconnectivity resistance to the degradation deposition *** dynamic immersion tests disclosed the reason for the different degradation rates on account of flow rates,which may bring insight into understanding of varied in vivo degradation rates related to implantation sites.

关键词： porous mg scaffold Degradability Porosity Dynamic immersion test Degradation rate

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