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Enhancing cell infiltration of electrospun fibrous scaffolds in tissue regeneration

Bioactive Materials 2016年第1期1卷 56-64页

作者： Jinglei Wu Yi Hong Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76019USA Joint Graduate Program in Biomedical Engineering University of Texas Southwestern Medical CenterDallasTX 75390USA

Electrospinning is one of the most effective approaches to fabricate tissue-engineered scaffolds composed of nano-to sub-microscale fibers that simulate a native extracellular ***,one major concern about electrospun scaffolds for tissue repair and regeneration is that their small pores defined by densely compacted fibers markedly hinder cell infiltration and tissue *** address this problem,researchers have developed and investigated various methods of manipulating scaffold structures to increase pore size or loosen the *** methods involve the use of physical treatments,such as salt leaching,gas foaming and custom-made collectors,and combined techniques to obtain electrospun scaffolds with loose fibrous structures and large *** article provides a summary of these motivating electrospinning techniques to enhance cell infiltration of electrospun scaffolds,which may inspire new electrospinning techniques and their new biomedical applications.

关键词： Electrospinning Scaffolds porosity control Cell infiltration Tissue regeneration

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Design, Analysis, Fabrication, and Test for Low-Cost and Out-of-Autoclave Composite Airship Gondolas

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Transactions of Nanjing University of Aeronautics and Astronautics 2022年第3期39卷 304-313页

作者： ZHU Qiang TONG Mingbo XIAO Peng LIU Chong QIU Chen MA Jingjing JIN Tao College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016P.R.China China Special Vehicle Research Institute Jingmen 448000P.R.China

Out-of-autoclave(OoA) processing has the advantages of low cost,light weight and environmental protection,and has become a hot spot in the field of composite materials worldwide. This paper investigates the application of OoA processing in the gondola of the AS700 civil manned airship. The production cost of gondolas is reduced by selecting low cost materials such as glass fiber,PVC foam and OoA processing. The porosity of parts is reduced and controlled at about 2% by optimizing the edge breathing of prepreg during curing. The maximum tensile strain of the glass fiber is 4 593 με;its maximum compressive strain is 3 680 με;and its maximum shear strain is4 884 με. The maximum Von Mises stress of the foam is 0.70 MPa. These settings all meet the margin requirement of safety. Finally,the ultimate load test of the gondola is carried out to verify the safety of the gondola structure. Our study presents critical parameters for the gondola design,including load,structure,strength,and manufacturing process test,and provides certain references for the design of similar products.

关键词： out-of-autoclave(OoA)processing airship gondola foam sandwich porosity control

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