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porcine placental peptides improve neuroblast proliferation and differentiation via enhancement of TrkB and BDNF levels in D-glatacose-induced mouse aging model

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Journal of Chinese Pharmaceutical Sciences 2019年第10期28卷 739-748页

作者： Xu Quan Caihong Gu Feng Yan Yaoyao Gao Lin Chen Rong Wei Bingchun Yan Rong Hul Department of Pharmacy Institute ofTranslational MedicineMedical CollegeYangzhou UniversinYamgzhou 225001JiangsuChina The Kev Laboratory of Syndrome Differentiation and Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine Yangzhou UniversityYangzhou 225001JiangsuChina Jiangsu Lianhuan Pharmaceutical Group Co. Ltd.Yangzhou 225009JianesuChina Jiangsu Yangnong Chemical Group Co LtdYangzhou 225001JiangsuChina Gaoyou Hospital of Traditional Chinese Medicine Yangzhou UniversiryYangzhou 225600JiangsuChina Tongzhou District People's Hospital Nantong 226300Jiangsu.China Nantong Tumor Hospital Nantong 226361JiangsuChina

Aging affects the nervous system as well as other *** our study,we aimed to study the pharmacological effects and mechanism of porcine placental peptides(PPP)in aging process,and to observe the changes of neuroblast proliferation and differentiation as well as partial gene expression in hippocampus of D-galactose-induced aged *** on the analysis of experimental results,it was confirmed that PPP significantly improved neurobalst proliferation and differentiation in the mouse hippocampal DG by ki-67 and DCX *** result showed that PPP had anti-aging effects on D-galactoseinduced aging mouse ***,we observed up-regulated expressions of BDNF and TrkB proteins and down-regulated expressions of Caspase 3,8,and 9 proteins in the PPP-treated mouse ***,our results showed that PPP obviously improved neuroblast proliferation and differentiation,and its anti-aging effect might berelated to down-regulation of apoptosis-related proteins,including Caspase 3,8,and 9,via BDNF/TrkB *** findings provided valuable evidence for its applications in the health and medicine sectors.

关键词： porcine placenta peptide Anti-aging Neuroblast proliferation and differentiation Apoptosis-related proteins BDNF/TrkB pathway

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