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Higher risk of type 2 diabetes in young women with polycystic ovary syndrome: A 10-year retrospective cohort study

World Journal of Diabetes 2022年第3期13卷 240-250页

作者： Wan-Ting Liao Jing-Yang Huang Ming-Tsung Lee Yu-Cih Yang Chun-Chi Wu Institute of Medicine Chung-Shan Medical UniversityTaichung 402Taiwan Chinese Medicine Department Show Chwan Memorial HospitalChanghua 500Taiwan Research Center for Health Data Science Chung Shan Medical University HospitalTaichung 402Taiwan National Center for Geriatrics and Welfare Research National Health Research InstitutesYunlin 632Taiwan Clinical Trial Research Center China Medical University HospitalTaichung 404Taiwan

BACKGROUND Polycystic ovary syndrome(PCOS)is a common disorder in women of reproductive *** the last few decades,research studies have revealed that PCOS is strongly associated with metabolic disorders,including metabolic syndrome,obesity,insulin resistance and *** observation has shown that women with PCOS are expected to have an increased risk of developing type 2 diabetes(T2DM)in the *** To assess the hazard ratio(HR)of T2DM between women with/without *** This population-based,retrospective cohort study evaluated data retrieved from the National Health Insurance Research *** subjects were women with PCOS(n=2545)identified on the basis of diagnosis,testing,or treatment codes,and women without PCOS as controls(n=2545).The HR of T2DM between women with or without PCOS was the main outcome measure *** Our study found that, during a 10-year follow-up period, the overall incidence of T2DM was 6.25per 1000 person-years in the PCOS group compared with 1.49 in the control group. Afteradjustment for potential confounding variables, the overall incidence of T2DM was higher in thePCOS group vs the control group (HR = 5.13, 95%CI: 3.51-7.48, P < 0.0001). The risk of developingT2DM subsequent to PCOS decreased with increasing diagnosis age: the adjusted HR was 10.4 inthe 18–24-year age group, 5.28 in the 25-29-year age group, and 4.06 in the 29-34-year age ***, no such significant association was noted in women older than 35 *** findings highlight the importance of prompting a more aggressive treatment to preventdiabetes in women diagnosed with PCOS at a young age, and, in contrast, the lessened importanceof this type of intervention in women diagnosed with PCOS at a late reproductive age.

关键词： Polycystic ovary syndrome Diabetes Incidence Hazard ratio population-based cohort study

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