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Clinical outcomes of sildenafil application in patients of poor endometrial development

Gynecology and Obstetrics Clinical Medicine 2022年第1期2卷 14-19页

作者： Meiling Guo Yuchen Yan Jianan Lv Hua Xin Wei Zhou Na Yu Mingdi Xia Jing Li Qian Zhang Junhao Yan Qigdao Women and Chiltren's Hapital QingrdoShandong266021China Cener for Reproductive Medicine Cheelbo College of MedicineShondong UniversipyJinanShondong250012China Key Labonatory of Reproductive Endcrinology of Minisry of Eduatin Shandong UnivensityJInanShandong 250012 China Shandong Key Labonatory of Reproductive Medicine JinanShandong 250012 China Shandong Provincial Cirical Research Cener for Reroductive Health JInanShundong250012 China National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong UniversilyJinanShandong 250012China Departnent of Ulorusonography Shandong Pravincial Hospital Aftited to Shandong Fist Medical UniversiyJIinanShandong250021China

Objective:To determine whether sildenafil has an efect on pregnancy outcomes in patients with poor endometrial ***:This study included 472 infertility patients who underwent in viro fer tilization/intracytoplasmadc spemm injection and frozen-thawed embryo tr ansfer(IVF/ICSI-FET)and subsequently sufered from poor endo-metral dewelopment during homnone replacement cycle(HRC)from April 2017 to July *** patients were divided into two groups:the sildenafl group(n=88)and the control group(n=384).We analyzed endometrial thicknuess and types on endometrial transformation day,as well as pregnancy outcomes after FET(biochemical pregnancy,clinical pregnancy,early abortion,late abortion,and live birth rates)between the two ***:After adjusting for confounding factors,we found no significant differences in endometrial thicknesses and types on endometrial transfomation day between the sildenafil group and the control group(0.79±0.08 vs 0.81±0.09,P=0.144;79.76%vs83.87%,P=0.402).There were also no statistcally significant differences in biochemical pregnancy rate(75.0%vs76.8%,P=0.892),clinical pregnancy rate(59.09%vs 69.53%,P=0.087),early abortion rate(17.31%vs 14.61%,P=0.557),late abortion rate(3.85%vs 4.49%,P=0.859),or live birth rate(45.45%vs 55.47%,P=0.101)between the two *** subgroup analysis,the application of sildenafil was unable to improve endometrial thickness(group one:0.80±0.08 cm vs 0.82±0.08 cm;group two:0.78±0.08 cm vs 0.80±0.10 cm;group three:0.75±0.11 cm vs 0.77±0.08 cm,p>0.05)and type endometrium on transfomation day(group one:78.57%vs 86.78%;group two:80.65%vs 77.78%;group three:81.82%ws.83.78%,p>0.05).Moreover,sildenafil use was not closely associated with clinical pregnancy outcomes,clinical pregnancy rate,early abortion rate,late abortion rate,and live birth rate(p>0.05).Conclusions:Sildenafl did not benefit endometrial development and pregnancy outcomes in patients with poor endometr:ial development during the hormone repl

关键词： Sildenafil poor endometrial development Pregnancy outcome

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