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polysaccharide krestin Prevents Alzheimer’s Disease-type Pathology and Cognitive Deficits by Enhancing Monocyte Amyloid-βProcessing

引用

Neuroscience Bulletin 2022年第3期38卷 290-302页

作者： Si-Han Chen Chen-Yang He Ying-Ying Shen Gui-Hua Zeng Ding-Yuan Tian Yuan Cheng Man-Yu Xu Dong-Yu Fan Cheng-Rong Tan An-Yu Shi Xian-Le Bu Yan-Jiang Wang Department of Neurology and Centre for Clinical Neuroscience Daping HospitalThird Military Medical UniversityChongqing400042China The Institute of Brain and Intelligence Third Military Medical UniversityChongqing400042China Chongqing Key Laboratory of Ageing and Brain Diseases Chongqing400042China State Key Laboratory of Trauma Burn and Combined InjuryDaping HospitalThird Military Medical UniversityChongqing400042China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai201200China Department of Neurology Nanchong Central HospitalThe Second Clinical Medical SchoolNorth Sichuan Medical CollegeNanchong637000China

Deficits in the clearance of amyloidβprotein(Aβ)by the peripheral system play a critical role in the pathogenesis of sporadic Alzheimer’s disease(AD).Impaired uptake of Aβby dysfunctional monocytes is deemed to be one of the major mechanisms underlying deficient peripheral Aβclearance in AD.In the current study,flow cytometry and biochemical and behavioral techniques were applied to investigate the effects of polysaccharide krestin(PSK)on AD-related pathology in vitro and in vivo.We found that PSK,widely used in therapy for various cancers,has the potential to enhance Aβuptake and intracellular processing by human monocytes in vitro.After administration of PSK by intraperitoneal injection,APP/PS1 mice performed better in behavioral tests,along with reduced Aβdeposition,neuroinflammation,neuronal loss,and tau hyperphosphorylation.These results suggest that PSK holds promise as a preventive agent for AD by strengthening the Aβclearance by blood monocytes and alleviating AD-like pathology.

关键词： Alzheimer’s disease Aβuptake polysaccharide krestin Monocyte

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