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Sub-nanosized vanadate hybrid clusters maintain glucose homeostasis and restore treatment response in inflammatory disease in obese mice

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Nano Research 2024年第3期17卷 1818-1826页

作者： Kun Chen Shengqiu Liu Yujun Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Technique and Equipment for Macromolecular Advanced Manufacturing South China University of TechnologyGuangzhou 510641China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China

Obesity is closely related with insulin resistance and chronic inflammation.Here,we report that unsaturated lipid-modified polyoxovanadates(ULPOVs)can restrict weight gain of diet-induced obese mice and improve their glycemic control and obesity-associated inflammation.Oral administration of the sub-nanosized ULPOVs at a low dosage for 7 weeks reduces the body weight and almost normalizes the blood glucose levels of obese mice fed on a high-fat diet.ULPOV treatment increases the activity of the nuclear receptor peroxisome proliferator-activated receptorγ(PPARγ)and reduces intestinal caloric intake,which may be the main reason for blood sugar and body weight control.In addition to insulin-sensitizing,PPARγactivation induced by ULPOV treatment in obese mice with atopic dermatitis(AD)promotes the type 2 T helper(TH_(2))cell selective responses and therapeutic effects on immune dysregulation caused by obesity.These data suggest sub-nanosized polyoxovanadate clusters as a class of potential candidates to relieve symptoms accompanied by diet-induced obesity.

关键词： polyoxovanadates lipid modification glucose homeostasis obesity inflammatory disease peroxisome proliferator-activated receptorγ(PPARγ)

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Weak interaction-steered evolution of polyoxovanadate-based metal-organic polyhedra from transformation via interlock to packing

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Chinese Chemical Letters 2024年第2期35卷 527-533页

作者： Yan-Hu Wang Ke-Wei Tong Chao-Qin Chen Jing Du Peng Yang College of Chemistry and Chemical Engineering Advanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082China College of Chemistry and Materials Science Testing and Analysis CenterHebei Normal UniversityShijiazhuang 050024China

A bottleneck in biomimetic synthesis consists in the full copy of,for example,the hierarchical structure of proteins directed by weak interactions.By contrast with covalent bonds bearing definite orientation and high stability,weak intermolecular forces within a continuous dynamic equilibrium can be hardly tamed for molecular design.In this endeavor,a ligand-dominated strategy that embodies tunable electrostatic repulsion andπ···πstacking was first employed to shape polyoxovanadate-based metal-organic polyhedra(VMOPs).Structural evolution involving transformation,interlock,and discovery of an unprecedented prototype of the Star of David was hence achievable.Not only as a handy tool for the primary structural control over VMOPs,these weak forces allow for an advanced management on the spatial distribution of such manmade macromolecules as well as the associated physicochemical behaviors,representing an ideal model for simulating and interpreting the conformation-function relationship of proteins.

关键词： Polyoxometalates polyoxovanadates Metal-organic polyhedron Interlock Weak intermolecular forces

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Polyoxovanadate-based metal-organic frameworks consisted of open vanadium sites for selective catalytic oxidation of sulfides

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钨科技(英文) 2023年第2期5卷 261-269页

作者： Jin-Lin Zhang Qi-Xin Zhao Meng-Yuan Cheng Wei-Min Xuan Yan Liu College of Chemistry and Chemical Engineering and State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua UniversityShanghai201620China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and State Key Laboratory of Metal Matrix CompositesShanghai Jiao Tong UniversityShanghai 200240China

Three novel polyoxovanadate-based metal-organic frameworks(POV-MOFs),[Co_(2)(1,4-dtzb)_(3)]{V_(4)O_(12)}(V-Co-MOF_(1),1,4-dtzb=1,4-di(4H-1,2,4-triazol-4-yl)benzene],[Co_(3)(1,3-dtzb)_(2)][{V_(6)O_(18)}(V-Co-MOF_(2),1,3-dtzb=1,3-di(4H-1,2,4-triazol-4-yl)benzene],[Co_(4)(4,4’-bdtzb)_(2)]{V_(8)O_(24)}(V-Co-MOF_(3),4,4’-bdtzb=4,4’-(1,1’-biphenyl)-4,4’-diylbis(4H-1,2,4-triazole)benzene]were facilely synthesized and structurally characterized.Single-crystal X-ray diffraction analysis indicates that all the POV-MOFs possess open V sites lined on POV clusters of{V_(4)O_(12)}/{V_(6)O_(18)}/{V_(8)O_(24)}that uniformly distribute on the robust three-dimensional frameworks.This unique structural feature allows them to show high performance for sulfidesulfoxide transformation when performing the reaction in MeOH at 50℃ for 45 min using H_(2)O_(2) as green oxidant.Notably,V-Co-MOF1 exhibited the highest catalytic efficiency,with a conversion>99% and selectivity up to 97% for a series of sulfide substrates.Control reaction demonstrated the catalytically active centers are the open V sites while the MOF skeleton constructed from Co^(2+)and ligands also contributes to enhance the conversion and selectivity via synergistic effect.Furthermore,V-Co-MOF1 can be used as a stable heterogeneous catalyst,and both the structural integrity and catalytic performance were well reserved after five cycles,demonstrating their great potential for advanced catalytic oxidation.

关键词： polyoxovanadates Polyoxometalate-based metal-organic framework Sulfoxide Catalytic oxidation

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Reducing obesity and inflammation in mice with organically-derivatized polyoxovanadate clusters

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Chinese Chemical Letters 2023年第5期34卷 631-636页

作者： Kun Chen Guoyong Dai Shengqiu Liu Yongge Wei South China Advanced Institute for Soft Matter Science and Technology School of Emergent Soft MatterSouth China University of TechnologyGuangzhou 510641China Key Lab of Organic Optoelectronics&Molecular Engineering of Ministry of Education Department of ChemistryTsinghua UniversityBeijing 100084China Guangdong Provincial Key Laboratory of Functional and Intelligent Hybrid Materials and Devices South China University of TechnologyGuangzhou 510641China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100191China

Obesity,characterized by the dysregulation of energy balance in adipose tissue and other metabolic organs,is frequently accompanied by chronic low-grade inflammation.As long-acting insulin sensitizers,the organically-derivatized polyoxovanadates(POVs),can extend the dosing interval of antidiabetic drugs from hourly to almost daily.In this work,the protective activity of POVs is investigated by an eight-week in vivo experiment,in which a small amount of POVs was administrated orally to a mouse model of dietinduced obesity every day.The present study shows that administration of POVs significantly decreases the body weight of mice,reduces adipose tissue accumulation,and simultaneously reduces adipose tissue inflammation.In addition,the anti-obesogenic population of i NKT cells is protected potentially by POVs,which subsequently alleviates visceral adipose tissue inflammation in high-fat-diet(HFD)-fed mice against diet-induced obesity.By contrast,the change in body weight after POV treatment is the result of a substantial reduction in fat mass,with no obvious effects on lean body mass.These findings demonstrate that supplementary of POVs would be an effective way to combat obesity and metabolic disorders while lowering metabolic inflammation.

关键词： polyoxovanadates Diet-induced obesity Anti-obesity Anti-inflammation Metabolic disease

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Investigation on the Photoelectric Properties of polyoxovanadates

Investigation on the Photoelectric Properties of Polyoxovana...

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中国化学会第七届全国多酸化学学术研讨会

作者： Jia-Peng Cao Feng-Cui Shen Xi-Ming Luo Chen-Hui Cui Ning-Fang Li Ya-Qian Lan Yan Xu College of Chemical Engineering State Key Laboratory of Materials-Oriented Chemical EngineeringNanjing Tech University Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials Jiangsu Key Laboratory of New Power Batteries School of Chemistry and Materials Science Nanjing Normal University

Triazole,similar as imidazole,makes a prominent contribution to proton conductivity of porous materials.To investigate the effect of triazole-based ligands in polyoxovanadates (POVs) on proton conduction,we designed and synthesized two decavanadate-based POVs,[Zn(CHN)(HO)](VO)·14HO (1) and[Zn(CHN)(HO)](VO)·8HO (2) constructed by the ligands 3-amino-1,2,4-triazole and 1H-1,2,4-triazole,respectively,via the aqueous solution evaporation method.Surprisingly,compound 1 obtained superior proton conductivity of 1.24×10 S cm under 60℃and 98%RH,which is much higher than that of compound 2.Furthermore,due to the contribution of the conjugate property of the ligands,we also tried its research of two-photon responses and achieved satisfactory results.To further investigate the third-order nonlinear optical (NLO) properties of POVs,two isolated polyoxovanadogermanates,[Cd(CHN)]{[Cd(CHN)][GeVO(OH)](HO)}·7HO (3)and{[Cd(CHN)][Cd(CHN)(HO)]}{[Cd(CHN)][Cd(CHN)]GeVO(OH)(HO)}·4HO (4),have been hydro-/solvothermally synthesized and structurally characterized.Notably,it is the first time to investigate the nonlinear optical (NLO) properties of vanadium-based heteropolyacids and obtain strong two photon responses.The results of open aperture Z-scan based on the two compounds manifest that they are the highest value among the reported polyoxovanadates and may be a decent potential NLO materials.At the same time,the electrochemical and electrocatalytic properties of compounds 3 were also measured in detail.

关键词： polyoxovanadates Proton Conductivity Third-order NLO Properties Electrochemical and Electrocatalytic Properties

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