检索结果-南通市图书馆

MSIsensor-pro: Fast, Accurate, and Matched-normal-sample-free Detection of Microsatellite Instability

Genomics, Proteomics & Bioinformatics 2020年第1期18卷 65-71页

作者： Peng Jia Xiaofei Yang Li Guo Bowen Liu Jiadong Lin Hao Liang Jianyong Sun Chengsheng Zhang Kai Ye School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China MOE Key Laboratory for Intelligent Networks&Networks Security Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Computer Science and Technology Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China School of Life Science and Technology Xi’an Jiaotong UniversityXi’an 710049China Leiden Institute of Advanced Computer Science Leiden UniversityLeiden 2311 ZENetherlands School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China Precision Medicine Center the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China Jackson Laboratory for Genomic Medicine FarmingtonCT 06032USA Genome Institute the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061China

Microsatellite instability(MSI)is a key biomarker for cancer therapy and *** experimental assays are laborious and time-consuming,and next-generation sequencingbased computational methods do not work on leukemia samples,paraffin-embedded samples,or patient-derived xenografts/organoids,due to the requirement of matched normal ***,we developed MSIsensor-pro,an open-source single sample MSI scoring method for research and clinical ***-pro introduces a multinomial distribution model to quantify polymerase slippages for each tumor sample and a discriminative site selection method to enable MSI detection without matched normal *** demonstrate that MSIsensor-pro is an ultrafast,accurate,and robust MSI calling *** samples with various sequencing depths and tumor purities,MSIsensor-pro significantly outperformed the current leading methods in both accuracy and computational ***-pro is available at https://***/xjtu-omics/msisensor-pro and free for non-commercial use,while a commercial license is provided upon request.

关键词： Microsatellite polymerase slippage Multinomial distribution Microsatellite instability Tumor

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：