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polydopamine Coating on Titanium Affects Osteoblastic Differentiation to a Greater Degree than Does Surface Roughness

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Advances in Materials Physics and Chemistry 2020年第12期10卷 339-349页

作者： Seyed Mohsen Latifi Ravi Shankar Henry J. Donahue Bone Engineering Science and Technology (BEST) Lab Virginia Commonwealth University Richmond USA

Biointerface design can greatly influence cell behavior. Therefore, in this study we examined the effects of three surface characteristics, roughness, chemistry, and wettability, on osteoblastic cell differentiation. We examined osteoblastic differentiation on titanium (Ti) samples with four levels of roughness (average roughness: 148.6 ± 23.1, 42 ± 6.2, 14.3 ± 5.5, 7.2 ± 1.6 nm) with or without a nanolayer coating of polydopamine (PDA). In vitro osteogenic differentiation was evaluated by quantifying alkaline phosphatase (AP) activity of human fetal preosteoblastic (hFOB 1.19) cells. The change in surface chemistry of Ti samples as a result of PDA coating was assessed by XPS analysis and water contact angle measurement. Results demonstrated that PDA treated samples were more hydrophilic, compared to untreated samples, and this was substrate roughness independent. Moreover, with the exception of the substrate with an oriented texture of surface nanotopography (RTi-4), the presence of a PDA nanolayer increased AP activity independent of substrate roughness. Our results suggest that surface chemistry and wettability, induced by a PDA nanolayer coating, had a greater effect on osteoblastic differentiation than did surface roughness.

关键词： Surface Chemistry Roughness polydopamine Wettability Osteoblastic Differentiation

polydopamine Modified Biomimetic Gold Nanoparticles for Dual Photothermal Therapy

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Advances in Modern Oncology Research 2019年第1期5卷 6-11页

作者： Zhiming Su Hem Sagar Rim China Medical Medicine Institute Beijing100000China Medicine Nepal Health Research Council44601Nepal

Our study producted polydopamine modified gold nanoflowers with controlled morphology for anti-tumor photothermal therapy.The branch structure containsabundant(Au NFs).By adjusting the reduction rate,the dosage of reducing agent(sodium borohydride)and the reduction temperature,we can adjust tthe morphology and particle size of Au NFs.We found that the lower reaction temperature is,the more abundant the surface branching structure of gold nanoflowers is,by adjusting the reaction temperature.and the largest specific surface area of golden nanopowder was found at 0℃.The results of TEM indicated that with the increase of sodium borohydride,the diameter of gold nano flowers gold nanoflowers decreased and was in the range of 60~100nm,and it has good EPR effect After that,we modify poly(dopamine)(PDA)biomimetic layer on the surface of golden nanoparticles to obtain Au NFS@PDA.Poly(dopamine)has the ability,of photothermal conversion,which can enhance the plasma resonance ability and biocompatibility of gold nanoflowers in the near infrared region.We can control the thickness of polydopamine layer on the surface of gold nanoflowers between 7~15nm by adjusting dopamine DA concentrationgold nanoflowers.Au NFS@PDA was characterized by its morphology and physical properties.We detect(UV-Vis)spectra in the near infrared region.And it showed obvious absorption peaks in the near infrared region of 575~650nm.Under the 808nm irradiation laser,the photothermal conversion of gold nanoflowers and polydopamine can be rapidly increased to 57°C.Fourier Transform Infrared Absorption Spectroscopy(FTIR)and X-ray Diffraction(XRD)analysis showed that polydopamine was modified successfully,Au NFS@PDA and Au NFs had no obvious difference in crystal form.The cell viability test showed that the bionic Au NFS@PDA had good biocompatibility and showed good antitumor activity against HeLa cells under NIR irradiation.The cell viability was only 12%.Therefore,we can use Au NFS@PDA with good biocompatibility as a promising photothermal conversion agent

关键词： gold nanoflowers polydopamine Template-free method Controllable Photothermal therapy

polydopamine Particles Effect on Melanoma Cells Proliferation and Melanin Secretion

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Advances in Chemical Engineering and Science 2013年第3期3卷 1-10页

作者： Sandy Eap Alice Ferrand Valérie Machi Vincent Ball Olivier Huck Nadia Benkirane-Jessel INSERM Institut National de la Santé et de la Recherche Médicale “Osteoarticular and Dental Regenerative Nanomedicine” Team Strasbourg France Université de Strasbourg Faculté de Chirurgie Dentaire Strasbourg France

Melanin is a biopolymer implicated in the protection of cellular membranes and DNA produced by melanocytes. This pigment has a dual role and should be considered as a photo-protector and as a photosensitizer due to its interaction with UV. The design of multifunctional and biologically responsive coatings is of major interest in modern biomaterials science. The aim of this study is not only to characterize the deposition of multilayered polyelectrolytes films made from polydopamine particles and polyamines like poly-(L-lysine hydrobromide) (PLL), but also to evaluate melanoma cells activity in terms of proliferation and their capacity to stimulate melanin secretion. One could expect that the presence of a melanin like material in the film may have a positive or a negative feedback on the melanin biosynthesis and consequently on melanoma development. Some comparisons are also done with pure polydopamine grains in suspension in the cell culture medium, to investigate if the immobilization of the polydopamine grains has an influence on their bioactivity.

关键词： polydopamine Particles Polyelectrolyte Multilayers Films Melanin Melanoma Cells

A Lightweight, Adhesive, Dual-Functionalized Over-Coating Interphase Toward Ultra-Stable High-Current Density Lithium Metal Anodes

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Energy & Environmental Materials 2021年第1期4卷 103-110页

作者： Shaowen Li Yue Ma Bingqing Wei State Key Laboratory of Solidification Processing Centre for Nano Energy Materials School of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072 China Department of Mechanical Engineering University of DelawareNewark DE19716 USA

Coherent manipulation of the lithium plating pattern is at the heart of the safe operation of metallic anodes in the battery technologies. In this article,a lightweight (~0.3 mg cm^(-2)), dual-functionalized carbon spheres are anchored onto the Cu foil as the interfacial protective layer via the chelation process of the catechol groups in the polydopamine precursor and the copper foil. The dual-functionalized carbon spheres exhibit the intriguing complementary features:Lithiophilic nitrogen dopants favor the Li+ion absorption and mitigate the nucleation barrier, while the micro/mesopore reservoir spatially homogenizes the ion flux distribution, confining the metallic propagation without dendrite-like protrusions. The metallic anode exhibits an ultra-stable plating/stripping process for 1 400 hr with the average Coulombic efficiency of ~99%. A full-cell prototype is constructed by pairing the N-doped carbon spheres on the bare Cu (NCS-Cu) electrode with the high-mass-loading LiVPO4F (12.5 mg cm^(-2)) cathode that can deliver a high energy density of 421.2 Wh kg^(-1) with the highest power density of 2106 W kg^(-1) to promise the anode use for high-power/energy-dense metallic batteries.

关键词： dual-functionalized carbon spheres hierarchical porosity lightweight protective layer metallic anode polydopamine

Bioactivation of titanium dioxide scaffolds by ALP-functionalization

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Bioactive Materials 2017年第2期2卷 108-115页

作者： A.Sengottuvelan P.Balasubramanian J.Will A.R.Boccaccini Department of Materials Science and Engineering Institute of BiomaterialsUniversity of Erlangen-NurembergCauerstraße 691058 ErlangenGermany

Three dimensional TiO2 scaffolds are receiving renewed attention for bone tissue engineering (TE) due totheir biocompatibility and attractive mechanical properties. However the bioactivity of these scaffolds iscomparatively lower than that of bioactive glass or hydroxyapatite (HA) scaffolds. One strategy toimprove bioactivity is to functionalize the surface of the scaffolds using biomolecules. Alkaline phosphatase(ALP) was chosen in this study due to its important role in the bone mineralization process. Thecurrent study investigated the ALP functionalization of 3D titanium dioxide scaffolds using selfpolymerizationof dopamine. Robust titanium scaffolds (compressive strength^2.7 ± 0.3 MPa) wereproduced via foam replica method. Enzyme grafting was performed by dip-coating in polydopamine/ALPsolution. The presence of ALP was indirectly confirmed by contact angle measurements and enzymaticactivity study. The influence of the enzyme on the bioactivity, e.g. hydroxyapatite formation on thescaffold surface, was measured in simulated body fluid (SBF). After 28 days in SBF, 5 mg ALP coatedtitania scaffolds exhibited increased hydroxyapatite formation. It was thus confirmed that ALP enhancesthe bioactivity of titania scaffolds, converting an inert bioceramic in an attractive bioactive system forbone TE.

关键词： Alkaline phosphatase Titanium dioxide Scaffolds polydopamine Surface modification Bioactivity

Multi-functionalized nanofibers with reactive oxygen species scavenging capability and fibrocartilage inductivity for tendon-bone integration

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Journal of Materials Science & Technology 2021年第11期70卷 91-104页

作者： Peixing Chen Sixiang Wang Zhi Huang Yan Gao Yu Zhang Chunli Wang Tingting Xia Linhao Li Wanqian Liu Li Yang Key Laboratory of Biorheological Science and Technology Ministry of EducationBioengineering CollegeChongqing UniversityChongqing400044China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China

The presence of excessive reactive oxygen species(ROS)after injuries to the enthesis could lead to cellular oxidative damage,high inflammatory response,chronic inflammation,and limited fibrochondral inductivity,making tissue repair and functional recovery difficult.Here,a multifunctional silk fibroin nanofiber modified with polydopamine and kartogenin was designed and fabricated to not only effectively reduce inflammation by scavenging ROS in the early stage of the enthesis healing but also enhance fibrocartilage formation with fibrochondrogenic induction in the later stages.The in vitro results confirmed the antioxidant capability and the fibrochondral inductivity of the functionalized nanofibers.In vivo studies showed that the multifunctional nanofiber can significantly improve the integration of tendon-bone and accelerate the regeneration of interface tissue,resulting in an excellent biomechanical property.Thus,the incorporation of antioxidant and bio-active molecules into extracellular matrix-like biomaterials in interface tissue engineering provides an integrative approach that facilitates damaged tissue regeneration and functional recovery,thereby improving the clinical outcome of the engineered tissue.

关键词： polydopamine Kartogenin Tendon-bone interface Reactive oxygen species Scavenging Fibrochondrogenic

Formation of uniform reduced graphene oxide films on modified PET substrates using drop-casting method

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Particuology 2014年第6期12卷 66-73页

作者： Chunlin Zhao Li Xing Junhui Xiang Lijie Cui JianbinJiao Huazheng Sai Zhenyou Li Fei Li College of Materials Science and Opto-Electronic Technology University of Chinese Academy of Sciences College of Chemistry and Chemical Engineering University of the Chinese Academy of Sciences College of Engineering and Information Technology University of the Chinese Academy of Sciences

In this work,uniform reduced graphene oxide（RGO） films were formed on poly-（ethylene terephthalate）（PET） substrates using a simple drop-casting method.We investigated four types of substrates：unmodified PET,polydopamine-coated PET.carboxyl-group-modified PET,and alkyl-group-modified PET.Upon water evaporation,the surface of the polydopamine-modified PET substrates can interact with the reduced graphene oxide sheets to form flattened and continuous RGO films,which exhibit a sheet resistance of 21.75 kΩ/sq at 82% transmittance.The result indicates that the properties of the surface groups determined whether uniform and flattened RGO films could be formed on the substrates.Hence,we proposed a simple and effective way to produce transparent and conductive films in which the catechol unit exhibits a great effect on the deposition of uniform RGO films on PET substrates.

关键词： Reduced graphene oxide Modified PET substrates Drop-casting polydopamine Transparent conductive films

Gram-scale synthesis of nanotherapeutic agents for CT/Tl-weighted MRI bimodal imaging guided photothermal therapy

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Nano Research 2017年第9期10卷 3124-3135页

作者： Xianguang Ding Xiaoxia Hao Dongdong Fu Mengxin Zhang Tian Lan Chunyan Li Renjun Huang Zhijun Zhang Yonggang Li Qiangbin Wang Jiang Jiang Lab and Division of Nanobiomedicine CAS Key Laboratory of Nano-Bio Interface CAS Center for Excellence in NanoscienceSuzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Suzhou 215123 China Department of Radiology The First Affiliated Hospital of Soochow University Suzhou 215006 China

Theranostic nanomedicine, which uses both imaging and therapeutic components for simultaneous disease diagnosis and treatment, is expected to improve patient treatment safety and outcomes by offering a more personalized approach to medicine. However, the poor reproducibilities of nanomedicines synthesized for optimized bioavailability and their potential toxicity are impeding clinical development. Moreover, milligram-scale synthetic methods are often inconsistent when transferred to mass production. To address these challenges, a facile, room temperature, aqueous phase synthesis of nanotheranostic agents using clinically validated mesoporous silica and naturally derived polydopamine has been developed. Since the synthetic procedure is simple and robust, and requires only simple mixing under ambient conditions, excellent batch-to-batch consistency has been achieved. As a result, this process can be easily scaled-up to produce gram-scale batches with physicochemical parameters similar to those of materials synthesized in smaller batches. The resulting nanotheranostic agents exhibit efficient X-ray tomography and T1-weighted magnetic resonance image contrast enhancing abilities due to their chemically ligated, benign Bi3+ and Fe3+ ions. Furthermore, the inclusion of a polydopamine shell makes the nanoparticle surface easy to functionalize and renders these materials highly efficient as photothermal agents. These nanotheranostic agents are suitable for mass production and for potential applications in multimodal imaging-guided therapy in clinical settings.

关键词： mesoporous silica polydopamine theranostic multimodal imaging mass production

Si/C particles on graphene sheet as stable anode for lithium-ion batteries

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Journal of Materials Science & Technology 2021年第21期80卷 259-265页

作者： Jian Han Xiaonan Tang Shaofan Ge Ying Shi Chengzhi Zhang Feng Li Shuo Bai Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang110016China School of Chemical Engineering Shandong University of TechnologyZibo255049China Jihua Laboratory Foshan528225China

Silicon is considered as one of the most promising anodes for Li-ion batteries(LIBs), but it is limited for commercial applications by the critical issue of large volume expansion during the lithiation. In this work, the structure of silicon/carbon(Si/C) particles on graphene sheets(Si/C–G) was obtained to solve the issue by using the void space of Si/C particles and graphene. Si/C–G material was from Si/PDA-GO that silicon particles was coated by polydopamine(PDA) and reacted with oxide graphene(GO). The Si/C–G material have good cycling performance as the stability of the structure during the lithiation/dislithiation.The Si/C–G anode materials exhibited high reversible capacity of 1910.5 mA h g^(-1) and 1196.1 mA h g^(-1) after 700 cycles at 357.9 m A g^(-1), and have good rate property of 507.2 mA h g^(-1) at high current density,showing significantly improved commercial viability of silicon electrodes in high-energy-density LIBs.

关键词： Li-ion batteries polydopamine Graphene sheets Silicon anode