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Structural and Functional Tailoring of Melanin-Like polydopamine Radical Scavengers

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CCS Chemistry 2020年第2期2卷 128-138页

作者： Peng Yang Zhipeng Gu Fang Zhu Yiwen Li College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Melanin is a ubiquitous but poorly understood polymeric,dark brown to black pigment biomaterial found both in nature and by organic *** structural heterogeneity and disordered covalent/noncovalent interactions make it a grand challenge to tune and improve the physical and biological properties of both melanin ***,we report a facile one-pot fabrication approach for synthetic melanins with controlled size and composition via copolymerization of dopamine and basic amino acid such as arginine in an aqueous *** resulting arginine-doped polydopamine melanin-like nanoparticles possess less ordered nonplanar microstructures within the particles,whereas the conventional polydopamine-based melanins contain a variety of compactπ-stacked *** assembly of these distinct polymeric microstructures could lead the preceding ones for greater accessibility to free radicals,with resultant stronger free-radical scavenging effect,and thus,exhibit superior antioxidant performance toward cellular oxidative *** work has inspired us to continue to fabricate new synthetic melanin pigments with tunable and improved functions by rational structural tailoring.

关键词： polydopamine synthetic melanin antioxidant free-radical scavenging structure-and-function

polydopamine Particles Effect on Melanoma Cells Proliferation and Melanin Secretion

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Advances in Chemical Engineering and Science 2013年第3期3卷 1-10页

作者： Sandy Eap Alice Ferrand Valérie Machi Vincent Ball Olivier Huck Nadia Benkirane-Jessel INSERM Institut National de la Santé et de la Recherche Médicale “Osteoarticular and Dental Regenerative Nanomedicine” Team Strasbourg France Université de Strasbourg Faculté de Chirurgie Dentaire Strasbourg France

Melanin is a biopolymer implicated in the protection of cellular membranes and DNA produced by melanocytes. This pigment has a dual role and should be considered as a photo-protector and as a photosensitizer due to its interaction with UV. The design of multifunctional and biologically responsive coatings is of major interest in modern biomaterials science. The aim of this study is not only to characterize the deposition of multilayered polyelectrolytes films made from polydopamine particles and polyamines like poly-(L-lysine hydrobromide) (PLL), but also to evaluate melanoma cells activity in terms of proliferation and their capacity to stimulate melanin secretion. One could expect that the presence of a melanin like material in the film may have a positive or a negative feedback on the melanin biosynthesis and consequently on melanoma development. Some comparisons are also done with pure polydopamine grains in suspension in the cell culture medium, to investigate if the immobilization of the polydopamine grains has an influence on their bioactivity.

关键词： polydopamine Particles Polyelectrolyte Multilayers Films Melanin Melanoma Cells

polydopamine Coating on Titanium Affects Osteoblastic Differentiation to a Greater Degree than Does Surface Roughness

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Advances in Materials Physics and Chemistry 2020年第12期10卷 339-349页

作者： Seyed Mohsen Latifi Ravi Shankar Henry J. Donahue Bone Engineering Science and Technology (BEST) Lab Virginia Commonwealth University Richmond USA

Biointerface design can greatly influence cell behavior. Therefore, in this study we examined the effects of three surface characteristics, roughness, chemistry, and wettability, on osteoblastic cell differentiation. We examined osteoblastic differentiation on titanium (Ti) samples with four levels of roughness (average roughness: 148.6 ± 23.1, 42 ± 6.2, 14.3 ± 5.5, 7.2 ± 1.6 nm) with or without a nanolayer coating of polydopamine (PDA). In vitro osteogenic differentiation was evaluated by quantifying alkaline phosphatase (AP) activity of human fetal preosteoblastic (hFOB 1.19) cells. The change in surface chemistry of Ti samples as a result of PDA coating was assessed by XPS analysis and water contact angle measurement. Results demonstrated that PDA treated samples were more hydrophilic, compared to untreated samples, and this was substrate roughness independent. Moreover, with the exception of the substrate with an oriented texture of surface nanotopography (RTi-4), the presence of a PDA nanolayer increased AP activity independent of substrate roughness. Our results suggest that surface chemistry and wettability, induced by a PDA nanolayer coating, had a greater effect on osteoblastic differentiation than did surface roughness.

关键词： Surface Chemistry Roughness polydopamine Wettability Osteoblastic Differentiation

polydopamine nanoparticles for treatment of acute inflammation-induced injury

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Polydopamine nanoparticles for treatment of acute inflammati...

Study on Water Resistance of polydopamine Treatment Wood Flour/Polypropylene Composites

第十二届全国免疫学学术大会

作者： zhao he Liu Zhuang Wang Jian Children's Hospital of Soochow University Soochow University

Nanotechnology-mediated anti-inflammatory therapy is emerging as a novel strategy for treatment of inflammation-induced ***,one of the main hurdles for these anti-inflammatory nano-drugs is their potential toxic side effects in ***,we uncovered that polydopamine(PDA) nanoparticles with structure and chemical properties similar to melanin,a natural bio-polymer,displayed significant anti-inflammation therapeutic effect on acute inflammation-induced *** with enriched phenol groups functioned as a radical scavenger to eliminate reactive oxygen species(ROS)generated during inflammatory *** revealed by in vivo photoacoustic imaging with a H O-specific nanoprobe,PDA nanoparticles remarkably reduced intracellular ROS levels in murine macrophages challenged with either H O or lipopolysaccharide(LPS).The anti-inflammatory capacity of PDA nanoparticles was further demonstrated in murine models of both acute peritonitis and acute lung injury(ALI),where significantly diminished ROS generation,substantially reduced proinflammatory cytokines,markedly attenuated neutrophil infiltration,and strongly alleviated lung tissue damage were observed in PDA-treated mice after a single dose of PDA *** work therefore presents the great promise of PDA nanoparticles as a biocompatible nano-drug for anti-inflammation therapy to treat acute inflammationinduced injury.

关键词： polydopamine Acute inflammation injury Reactive oxygen species Anti-inflammation therapy

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Journal of Materials Science and Chemical Engineering 2016年第5期4卷 7-15页

作者： Do Khoa Thi Lanh Tran Duc Thien Department of Polymer Science and Materials Sichuan University Chengdu China Vietnam National University of Forestry Hanoi Vietnam

This paper aims to investigate the water absorption of wood flour/polypropylene composites and its effects on dimensional stability and crystallization properties. Wood-plastic composites (WPCs) makes using polydopamine modified wood flour (WF-D), virgin polypropylene, maleic anhydride-grafted polypropylene (MA) and antioxidant, by using hot-pressing moulding. Water absorption (WA), thickness swelling (TS) and failure of flexural properties of the composites have studied for a range of immersion times. It is found that the WA and TS have increased with WF content and immersion time. The water absorption and thickness swelling of WPCs are 0.85% and 0.99%, respectively, after 8 days immersion. With the prolonging of immersion time, the impact strength, flexural strength and flexural modulus of WPCs increase first and then decrease. The impact strength decreases from 3.32 kJ/m2 to 2.94 kJ/m2, the retention rate is 88.55%;the flexural strength and flexural modulus by 68.58 Mpa and 3.92 Gpa, respectively. WPCs crystallization and thermal properties decrease slightly. Microstructures of the composites are examined to understand the mechanisms for the wood-plastic interaction which affects the water absorption and thickness swelling. Our work demonstrates that using polydopamine treatment wood flour for preparing WPCs can be an efficient way to improve the water resistance of WPCs.

关键词： Wood Flour Water Absorption Polypropylene Wood-Plastic Composites polydopamine Thickness Swelling

How polydopamine Modulates Biological Responses to PTFE Prostheses

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Materials Sciences and Applications 2019年第5期10卷 377-392页

作者： Isabelle Talon Anne Schneider Eric Mathieu Bernard Senger Benoit Frisch Cendrine Seguin Vincent Ball Joseph Hemmerlé National Institute of Health and Medical Research INSERM UMR_S 1121 11 rue Humann Strasbourg France Pediatric surgery Department University Hospital of Strasbourg Avenue de Moliere Strasbourg France National Center of Scientific Research CNRS UMR_7199 UMR_7199 University of Pharmacy of Strasbourg 74 Route du Rhin-CS 60024 Illkirch Cedex France

Diaphragm repair after congenital diaphragmatic hernia is associated with hernia recurrence due to prosthesis failure. Expanded polytetrafluoroethylene (e-PTFE), a synthetic non-degradable biomaterial, is currently used for those diaphragmatic defect repairs. The drawback of e-PTFE is its poor wettability that leads to coating difficulties, bonding that could favor implant integration. However, polydopamine (PDA) can be deposited as well on organic as on inorganic substrates. Therefore, we assessed the biological responses of a clinically used e-PTFE biomaterial treated with PDA in two different manners: one impregnated with PDA and the other coated with a one side PDA film. Mechanical properties of the raw e-PTFE, the PDA soaked biomaterial and the PDA coated surface were characterized by colloidal probe atomic force microscopy. Behaviors of primary human fibroblasts and Wharton’s jelly stem cells were investigated by electron microscopy. Findings reveal that the mechanical properties at the microscopic scale are not modified by the PDA treatments. Cells spread onto both PDA functionalized substrates. In addition, microscopic observations disclose numerous focal cell contacts, evidencing cell attachment, and cytoplasmic projections particularly with the nanoscale PDA coating. Results clearly suggest that PDA in general but above all the PDA coating enhance cellular colonization of the implant material.

关键词： Biomaterials Expanded Polytetrafluoroethylene polydopamine Functionalization Electron Microscopy

Structural disruption of melanin-like polymers with boosted UV protection

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Science China Chemistry 2024年第5期67卷 1653-1663页

作者： Zhen Yang Xianheng Wang Wanjie Bai Zikun Zou Haoxing Wu Yiwen Li Department of Radiology Huaxi MR Research CenterFunctional and Molecular Imaging Key Laboratory of Sichuan ProvinceNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengdu 610041China College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu 610065China

Manipulating the energy structure of materials represents an efficient way to regulate their light absorption behaviors. For example, constructing donor-acceptor(D-A) structures to increase the polarizability and reduce the energy bandgap of local molecules has been widely used in the field of organic photovoltaics with ordered structures. Remarkably, even in disordered and chaotic systems such as melanin-like polydopamine(PDA), visible and near-infrared light absorption can be significantly improved using this strategy. However, there has been a noticeable dearth of research on the ultraviolet(UV) light absorption regulation of bioinspired polymers with disordered and chaotic architectures by tailoring the D-A microstructures. In this study, a series of benzoheterocyclic molecules with strong electron-donating features screened by molecular simulation calculations were involved in disrupting the D-A structures within PDA. The destruction of D-A structures promoted the increase of the energy band gap and finally boosted the UV absorption of PDA. The resulting PDA nanoparticles with enhanced UV absorption were further employed to fabricate UV shielding composite films to protect the growth of plants from harmful UV radiation. This research may open up new avenues for structural disruption of bioinspired polymers for enhanced photoprotection applications.

关键词： melanin-like polymers polydopamine D-A structure UV absorption photoprotection

Highly Conductive Ag/pCF/MVQ Composite Rubber for Efficient Electromagnetic Interference Shielding

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Chinese Journal of Polymer Science 2024年第6期42卷 864-873页

作者： Yang Chen Xiao-Ming Shao Liang He Yi-Nuo Xu Qi-Yuan Yao Ding Feng Wen-Cai Wang State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing100029China Key Laboratory of Beijing City for Preparation and Processing of Novel Polymer Materials Beijing University of Chemical TechnologyBeijing100029China Sino-german School of Engineering Qingdao University of Science and TechnologyQingdao266400China

In this study,flexible and highly conductive composite rubber at low filler content was successfully prepared through polydopamine-assisted electroless silver plating plus mechanical ***,carbon fibers(CF)were activated by polydopamine(PDA)to improve the surface activity by self-polymerization ***,because of the metal chelating ability of PDA,silver layer was firmly deposited on the surface of CF through a facile electroless silver plating ***,flexible silver-plated carbon fibers(Ag/pCF)silicone rubber composites prepared by mechanical *** using X-ray photoelectron spectroscopy(XPS)and X-ray diffraction(XRD),the chemical composition and crystal structure of Ag/pCF were examined,and scanning electron microscopy(SEM)was used to assess the surface morphology of the Ag/*** results showed that a uniform and dense silver layer was formed on the surface of the CF,and the conductivity of the Ag/pCF could reach 7885 S/*** was noteworthy that the composite rubber filled with only 45 phr Ag/pCF had a high electromagnetic interference shielding effectiveness(100 dB)due to the low density and high aspect ratio of Ag/*** composite rubber has excellent potential for application in the field of electromagnetic interference shielding.

关键词： Carbon fibers polydopamine Electroless plating Silver Electromagnetic interference shielding

Anti-aging performance improvement and enhanced combustion efficiency of boron via the coating of PDA

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Defence Technology（防务技术） 2024年第3期33卷 399-410页

作者： Shuai Ma Qinghai Shu Mengyang Zhang Hongyu Huang Yansong Shi Xijuan Lv Shuai Zhao School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement(MOE) Beijing Key Lab of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of TechnologyBeijing100081China Tangshan Research Institute of Beijing Institute of Technology Tangshan063000HebeiChina

Boron is an ambitious fuel in energetic materials since its high heat release values,but its application is prohibited by low combustion efficiency and oxidization during *** polydopamine(PDA)was introduced into boron particles,investigating the impact of PDA content on the energetic behavior of *** results indicated that the PDA coating formed a fishing net structure on the surface of boron *** heat release results showed that the combustion calorific value of B@PDA was higher than that of the raw ***,the actual combustion heat of boron powder in B@10%PDA increased by 38.08%.Meanwhile,the DSC peak temperature decreased by 100.65℃under similar oxidation rate compared to raw ***,the B@PDA@AP and B@AP composites were prepared,and their combustion properties were *** was demonstrated that B@10%PDA@AP exhibited superior performance in terms of peak pressure and burning time,*** peak pressure is 12.43 kPa more than B@AP and burning time is 2.22 times higher than B@***,the coating of PDA effectively inhibits the oxidization of boron during storage and enhances the energetic behavior of boron and corresponding composites.

关键词： Boron particles polydopamine Anti-aging performance improvement Heat release