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polydopamine-modified chitin conduits with sustained release of bioactive peptides enhance peripheral nerve regeneration in rats

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Neural Regeneration Research 2022年第11期17卷 2544-2550页

作者： Ci Li Song-Yang Liu Li-Ping Zhou Tian-Tian Min Meng Zhang Wei Pi Yong-Qiang Wen Pei-Xun Zhang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration Ministry of EducationBeijingChina National Center for Trauma Medicine BeijingChina Beijing Key Laboratory for Bioengineering and Sensing Technology School of Chemistry and Biological EngineeringUniversity of Science and Technology BeijingBeijingChina

The introduction of neurotrophic factors into injured peripheral nerve sites is beneficial to peripheral nerve regeneration.However,neurotrophic facto rs are rapidly degraded in vivo and obstruct axonal regeneration when used at a supraphysiological dose,which limits their clinical benefits.Bioactive mimetic peptides have been developed to be used in place of neurotrophic factors because they have a similar mode of action to the original growth fa ctors and can activate the equivalent receptors but have simplified sequences and structures.In this study,we created polydopamine-modified chitin conduits loaded with brain-derived neurotrophic factor mimetic peptides and vascular endothelial growth fa ctor mimetic peptides(Chi/PDA-Ps).We found that the Chi/PDA-Ps conduits were less cytotoxic in vitro than chitin conduits alone and provided sustained release of functional peptides.In this study,we evaluated the biocompatibility of the Chi/P DA-Ps conduits.Brain-derived neurotrophic factor mimetic peptide and vascular endothelial growth fa ctor mimetic peptide synergistically promoted prolife ration of Schwann cells and secretion of neurotrophic factors by Schwann cells and attachment and migration of endothelial cells in vitro.The Chi/P DA-Ps conduits were used to bridge a 2 mm gap between the nerve stumps in rat models of sciatic nerve injury.We found that the application of Chi/PDA-Ps conduits could improve the motor function of rats and reduce gastrocnemius atrophy.The electrophysiological results and the microstructure of regenerative nerves showed that the nerve conduction function and re myelination was further resto red.These findings suggest that the Chi/PDA-Ps conduits have great potential in peripheral nerve injury repair.

关键词： angiogenesis bioactive peptides nerve repair neurotrophic factor peripheral nerve injury peripheral nerve regeneration polydopamine surface modification synergistic effects tissue engineering

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polydopamine-Based Colorimetric Superwettable Biosensor for Highly Sensitive Detection of Hydrogen Peroxide and Glucose

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Journal of Analysis and Testing 2023年第2期7卷 118-127页

作者： Jinze Li Yuhao Li Zhongfeng Gao Key Laboratory of Interfacial Reaction and Sensing Analysis in Universities of Shandong School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China College of Chemistry and Chemical Engineering Linyi UniversityLinyi 276005China

Superwettable surface has broad application prospects in fabricating biosensors due to its significant enrichment effect.Here,we report a polydopamine-based colorimetric superwettable sensor that integrates superhydrophobic-superhydrophilic micropatterns for the determination of hydrogen peroxide(H_(2)O_(2))and glucose.Dopamine can be oxidized into polydopamine with the addition of horseradish peroxidase(HRP)and H_(2)O_(2),leading to the deposited spots color change from colorless to black.The concentration of target can be determined by analyzing RGB value using a smartphone software.The superhydrophobic area on the superwettable surface helps capture droplets by confining them to superhydrophilic microwells.After droplet evaporation,the analytes are concentrated in the small superhydrophilic domain,thus greatly enhancing the sensitivity.The experimental results manifested that superwettable sensor is able to detect H_(2)O_(2)with a broad linear range of 0.25μmol/L-25 mmol/L and a low limit of detection(LOD)of 0.25μmol/L by naked eye.For glucose detection,the linear range of the sensor is from 2μmol/L to 20 mmol/L and LOD is 0.69μmol/L.The superwettable sensor has been successfully applied in practical samples,including cancerous cells,milk,urine,and human serum samples with acceptable results.This superwettable sensor has several merits,such as high sensitivity,rapid response,and low sample volume in a single microdroplet,and shows great potential in manufacturing portable devices for complex biosensing applications.

关键词： Colorimetric assay polydopamine Hydrogen peroxide Glucose detection Superwettable sensor

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polydopamine nanolayer assisted internal photo-deposition of CdS nanocrystals for stable cosensitized photoanode

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Nano Research 2022年第10期15卷 8836-8845页

作者： Na Li Lu Han Hainan Zhang Juntong Huang Xudong Luo Xibao Li Yuanhao Wang Weiqi Qian Ya Yang School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China School of Materials Science and Engineering Nanchang Hangkong UniversityNanchang 330063China SUSTech Engineering Innovation Center School of Environmental Science and EngineeringSouthern University of Science and TechnologyShenzhen 518055China CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and SensorBeijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China

Hydrogen evolution via photo-electro-chemical(PEC)co-catalysis is potential for solving energy crisis and environmental issues.The rapidly advances of fabrication and broad applications of polydopamine(PDA)and its derivatives have drawn intense attentions in recent years.Herein,an ultrathin PDA coating with nanometer accuracy was conformally grown on TiO_(2) nanotube arrays(NTAs)via electrochemical polymerization,in which the polymer provided a platform for further photoinduced assembly of CdS nanocrystals in the embedded mode.The optimized CdS@PDA/TiO_(2) NTAs hierarchical heterostructure as photoanode gave an excellent PEC performance and exhibited outstanding stability under light irradiation.The photocurrent density was heightened to 5.48 mA·cm^(–2),which was beneficial to H_(2) evolution with a rate of 20μmol·h^(–1)·cm^(–2).The improvement of PEC activity was ascribed to co-photosensitization,optimized carriers transfer,and transport route arised from CdS embedding,resulting to provide a persistent driving force for charge separation based on secure heterojunction of CdS/TiO_(2) glued by PDA.The improvement of PEC stability was due to the inhibition of CdS photocorrosion covered by PDA shelter.This advance boded well for the development of PEC field founded on multifunctional PDA.

关键词： polydopamine TiO_(2)nanotube arrays photoelectrocatalysis photocorrosion

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polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes

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Bioactive Materials 2022年第12期7卷 213-227页

作者： Yazhen Li Lu Yang Yue Hou Zhenzhen Zhang Miao Chen Maoxia Wang Jin Liu Jun Wang Zhihe Zhao Chaoming Xie Xiong Lu State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of OrthodonticsWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengduSichuan610031China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Oral ImplantologyWest China Hospital of StomatologySichuan UniversityChengduSichuan610041China Lab for Aging Research and National Clinical Research Center for Geriatrics West China HospitalSichuan UniversityChengduSichuan610041China

Regenerating periodontal bone tissues in the aggravated inflammatory periodontal microenvironment under diabetic conditions is a great challenge.Here,a polydopamine-mediated graphene oxide(PGO)and hydroxyapatite nanoparticle(PHA)-incorporated conductive alginate/gelatin(AG)scaffold is developed to accelerate periodontal bone regeneration by modulating the diabetic inflammatory microenvironment.PHA confers the scaffold with osteoinductivity and PGO provides a conductive pathway for the scaffold.The conductive scaffold promotes bone regeneration by transferring endogenous electrical signals to cells and activating Ca2+channels.Moreover,the scaffold with polydopamine-mediated nanomaterials has a reactive oxygen species(ROS)-scavenging ability and anti-inflammatory activity.It also exhibits an immunomodulatory ability that suppresses M1 macrophage polarization and activates M2 macrophages to secrete osteogenesis-related cytokines by mediating glycolytic and RhoA/ROCK pathways in macrophages.The scaffold induces excellent bone regeneration in periodontal bone defects of diabetic rats because of the synergistic effects of good conductive,ROS-scavenging,anti-inflammatory,and immunomodulatory abilities.This study provides fundamental insights into the synergistical effects of conductivity,osteoinductivity,and immunomodulatory abilities on bone regeneration and offers a novel strategy to design immunomodulatory biomaterials for treatment of immune-related diseases and tissue regeneration.

关键词： polydopamine Graphene oxide Conductive scaffold ROS-Scavenging Macrophage polarization

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Sustained release of exosomes loaded into polydopamine-modified chitin conduits promotes peripheral nerve regeneration in rats

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Neural Regeneration Research 2022年第9期17卷 2050-2057页

作者： Ci Li Song-Yang Liu Meng Zhang Wei Pi Bo Wang Qi-Cheng Li Chang-Feng Lu Pei-Xun Zhang Department of Orthopedics and Trauma Peking University People’s HospitalBeijingChina Key Laboratory of Trauma and Neural Regeneration Ministry of EducationBeijingChina National Center for Trauma Medicine BeijingChina Department of Orthopedics Beijing Jishuitan HospitalBeijingChina

Exosomes derived from mesenchymal stem cells are of therapeutic interest because of their important role in intracellular communication and biological regulation.On the basis of previously studied nerve conduits,we designed a polydopamine-modified chitin conduit loaded with mesenchymal stem cell-derived exosomes that release the exosomes in a sustained and stable manner.In vitro experiments revealed that rat mesenchymal stem cell-derived exosomes enhanced Schwann cell proliferation and secretion of neurotrophic and growth factors,increased the expression of Jun and Sox2 genes,decreased the expression of Mbp and Krox20 genes in Schwann cells,and reprogrammed Schwann cells to a repair phenotype.Furthermore,mesenchymal stem cell-derived exosomes promoted neurite growth of dorsal root ganglia.The polydopamine-modified chitin conduits loaded with mesenchymal stem cell-derived exosomes were used to bridge 2 mm rat sciatic nerve defects.Sustained release of exosomes greatly accelerated nerve healing and improved nerve function.These findings confirm that sustained release of mesenchymal stem cell-derived exosomes loaded into polydopamine-modified chitin conduits promotes the functional recovery of injured peripheral nerves.

关键词： exosome mesenchymal stem cells modification strategy nerve conduits peripheral nerve injury peripheral nerve regeneration polydopamine reprogramming state Schwann cells sustained release

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Inhaled curcumin mesoporous polydopamine nanoparticles against radiation pneumonitis

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2522-2532页

作者： Ting Chen Bo Zhuang Yueqi Huang Yan Liu Bochuan Yuan Wanmei Wang Tianyu Yuan Lina Du Yiguang Jin Guangdong Pharmaceutical University Guangzhou 510006China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Chemical Defense Institute of NBC DefenseBeijing 102205China

Radiation therapy is an effective method to kill cancer cells and shrink tumors using highenergy X-ray or γ-ray. Radiation pneumonitis(RP) is one of the most serious complications of radiation therapy for thoracic cancers, commonly leading to serious respiratory distress and poor prognosis. Here,we prepared curcumin-loaded mesoporous polydopamine nanoparticles(CMPN) for prevention and treatment of RP by pulmonary delivery. Mesoporous polydopamine nanoparticles(MPDA) were successfully synthesized with an emulsion-induced interface polymerization method and curcumin was loaded in MPDA via π-π stacking and hydrogen bonding interaction. MPDA owned the uniform spherical morphology with numerous mesopores that disappeared after loading curcumin. More than 80% curcumin released from CMPN in 6 h and mesopores recovered. CMPN remarkably protected BEAS-2 B cells from γ-ray radiation injury by inhibiting apoptosis. RP rat models were established after a single dose of15 Gy^(60)Co γ-ray radiation was performed on the chest area. Effective therapy of RP was achieved by intratracheal administration of CMPN due to free radical scavenging and anti-oxidation ability, and reduced proinflammatory cytokines, high superoxide dismutase, decreased malondialdehyde, and alleviated lung tissue damages were observed. Inhaled CMPN paves a new avenue for the treatment of RP.

关键词： Radiation pneumonitis Curcumin Mesoporous polydopamine Nanoparticle Pulmonary delivery Inhalation Free radical scavenging

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Chemo-photothermal immunotherapy for eradication of orthotopic tumors and inhibition of metastasis by intratumoral injection of polydopamine versatile hydrogels

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Acta Pharmaceutica Sinica B 2022年第3期12卷 1447-1459页

作者： Bo Zhuang Ting Chen Yueqi Huang Zhimei Xiao Yiguang Jin Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Department of Chemical Defense Institute of NBC DefenseBeijing 102205China

Cancer remains one of the leading causes of death globally and metastasis always leads to treatment failure.Here,we develop a versatile hydrogel loading photothermal agents,chemotherapeutics,and immune-adjuvants to eradicate orthotopic tumors and inhibit metastasis by combinational therapy.Hydrogel networks were synthesized via the thiol-Michael addition of polydopamine(PDA)with thiolated hyaluronic acid.PDA acted as a cross-linking agent and endowed the hydrogel with excellent photothermal property.Meanwhile,a chemotherapeutic agent,doxorubicin(DOX),was loaded in the hydrogel viaπ-πstacking with PDA and an immune-adjuvant,CpG-ODN,was loaded via electrostatic interaction.The release of DOX from the hydrogel was initially slow but accelerated due to near infrared light irradiation.The hydrogels showed remarkably synergistic effect against 4T1 cancer cells and stimulated plenty of cytokines secreting from RAW264.7 cells.Moreover,the hydrogels eradicated orthotopic murine breast cancer xenografts and strongly inhibited metastasis after intratumoral injection and light irradiation.The high anticancer efficiency of this chemo-photothermal immunotherapy resulted from the strong synergistic effect of the versatile hydrogels,including the evoked host immune response.The combinational strategy of chemo-photothermal immunotherapy is promising for highly effective treatment of breast cancer.

关键词： Breast cancer polydopamine Hydrogel Intratumoral injection Photothermal Chemotherapy Immunotherapy Metastasis

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Dimethylamino group modified polydopamine nanoparticles with positive charges to scavenge cell-free DNA for rheumatoid arthritis therapy

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Bioactive Materials 2022年第12期7卷 409-420页

作者： Ying Chen Yonglin Wang Xianfang Jiang Jinhong Cai Yuting Chen Hanji Huang Yuan Yang Li Zheng Jinmin Zhao Ming Gao Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Guangxi Collaborative Innovation Center of Regenerative Medicine and Medical Bioresource Development and Application The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of Orthopedics The First Affiliated Hospital of Guangxi Medical UniversityNanning530021China Department of Oral Radiology College of Stomatology of Guangxi Medical UniversityNanning530021China Guangxi Key Laboratory of Regenerative Medicine International Joint Laboratory on Regeneration of Bone and Soft TissuesThe First Affiliated Hospital of Guangxi Medical UniversityNanning530021China

Excessive cell-free DNA(cfDNA)released by damaged or apoptotic cells can cause inflammation,impacting the progression of rheumatoid arthritis(RA).cfDNA scavengers,such as cationic nanoparticles(NPs),have been demonstrated as an efficient strategy for treating RA.However,most scavengers are limited by unfavorable biocompatibility and poor scavenging efficacy.Herein,by exploiting the favorable biocompatibility,biodegradability and bioadhesion of polydopamine(P),we modified P with dimethylamino groups to form altered charged DPs to bind negatively charged cfDNA for RA therapy.Results showed that DPs endowed with superior binding affinity of cfDNA and little cytotoxicity,which effectively inhibited lipopolysaccharide(LPS)stimulated inflammation in vitro,resulting in the relief of joint swelling,synovial hyperplasia and cartilage destruction in RA rats.Significantly,DPs with higher DS of bis dimethylamino group exhibited higher positive charge density and stronger cfDNA binding affinity,leading to excellent RA therapeutic effect among all of the treated groups,which was even close to normal rats.These finding provides a novel strategy for the treatment of cfDNA-associated diseases.

关键词： Cell-free DNA polydopamine Rheumatoid arthritis Nucleic acid binding affinity Immunotherapy

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Recent Advances in Bio-Inspired Versatile polydopamine Platforms for “Smart” Cancer Photothermal Therapy

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Chinese Journal of Polymer Science 2023年第5期41卷 699-712,I0007页

作者： Zhi-Yuan Ma Dan-Ya Li Xin Jia Rui-Li Wang Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringDonghua UniversityShanghai 201620China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003China

Although photothermal therapy(PTT)has been developed for fighting cancers,the degradative,toxic,and metabolic nature of photothermal conversion materials(PCMs)has prevented them from being clinically implemented.Taking advantage of the surface modification strategy of mussel-inspired dopamine chemistry and its excellent photothermal conversion effect,polydopamine(Pdop)represents a versatile PTT platform,providing strategies and methods for the construction of novel Pdop-functionalized PCMs.Thanks to its adhesion and secondary reactivity,Pdop can be deposited on virtually all substrates to improve their bioavailability and biocompatibility.Pdop-based PCMs could not be only functionalized with small biomolecules via chemical bonds and/or noncovalent force but also modified with functional polymers via either the“grafting to”or“grafting from”method.This review highlights the synthetic methods,therapeutic strategies,and designs of PCMs based on Pdop in recent years to explore its scope and limitations.

关键词： polydopamine Photothermal therapy Drug delivery systems Polymers Tumor theranostics

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A Novel Method to Improve the Physical Property and Biocompatibility of Decellularized Heart Valve Scaffold with Sericin and polydopamine

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Journal of Bionic Engineering 2022年第4期19卷 1109-1123页

作者： Peng Bai Gangcheng Kong Weihua Qiao Yu Song Yixuan Wang Jiawei Shi Nan Zhang Chungeng Liu Chong Chu Tixiusi Xiong Ying Zhou Cuifen Lu Lin Wang Nianguo Dong Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhou 310003China Research Center for Tissue Engineering and Regenerative Medicine Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Endocrinology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430032China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry Hubei UniversityWuhan 430062China Department of Clinical Laboratory Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Cardiac valve replacement is an effective method to treat valvular heart disease.Artificial valves used routinely in clinic still have defects.In our study,we explored a novel method to modify the performance of Decellularized Heart Valve(DHV)scaffold.The decellularized porcine aortic valve was prepared using sequential hydrophile and lipophile solubilization method.The sericin was extracted from silk fibroin-deficient silkworm cocoon by lithium bromide method.First,DHV was immersed in sericin solution to produce the sericin–DHV composite scaffold.Then,we modified the DHV by making a polydopamine(PDA)coating on the DHV first and then binding the sericin.The physical properties and biological compatibility of our composite scaffold were assessed in vitro and in vivo.Sericin were successfully prepared,combined to DHV and improved its biocompatibility.PDA coating further promoted the combination of sericin on DHV and improved the physical properties of scaffolds.The decay rate of our modified valve scaffold was decreased in vivo and it showed good compatibility with blood.In conclusion,our modification improved the physical properties and biocompatibility of the valve scaffold.The combination of PDA and sericin promoted the recellularization of decellularized valves,showing great potential to be a novel artificial valve.

关键词： Decellularized heart valve Sericin polydopamine Biocompatibility

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