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Evaluation the Properties of polycaprolactone/Fluorapatite Nano-biocomposite

Journal of Bionic Engineering 2022年第1期19卷 179-187页

作者： Mojtaba Momeni Kamran Amini Ali Heidari Mohammad Khodaei Department of Mechanical Engineering Khomeinishahr BranchIslamic Azad UniversityKhomeinishahr84181-48499IsfahanIran Center for Advanced Engineering Research Majlesi BranchIslamic Azad University86316-56451IsfahanIran Materials Engineering Group Golpayegan College of EngineeringIsfahan University of Technology87717-67498GolpayeganIran

In this study,nano-biocomposites of polycaprolactone(PCL)as the matrix and different amounts of nanofluorapatite(nFA)(0,10,20 and 30 wt.%)as the reinforcement were prepared for possible scaffold fabrication using the fused filament fabrication(FFF)3D *** Emission Scanning Electron Microscopy(FE-SEM)and Energy Dispersive Spectroscopy(EDS)showed that nFA particles were well distributed in the PCL matrix.X-ray diffraction analysis(XRD)and Fourier Transform Infrared Spectroscopy(FTIR)depicted no chemical interaction between the elements of the *** Scanning Calorimetric(DSC)analysis was then used to assess the thermal properties of the composites,suggesting that this could be due to the amorphous phase formation of the intermolecular hydrogen bonds between PCL and nFA,resulting in the suppression of PCL *** results of mechanical characterization also showed that the addition of nFA up to 20 wt.%to the PCL increased the tensile and yield strength,as well as reducing the elongation at both yield and failure points and increasing the Young *** best mechanical properties were obtained for the PCL/20nFA *** strength and Young modulus were increased by 30%and 179%,respectively;meanwhile,elongation of PCL/20nFA was decreased by 70%,as compared to the naked *** changes could be attributed to the better distribution of the nFA filler in the PCL *** to the obtained results,PCL/20nFA could be regarded as a good composite in terms of the mechanical properties for the regeneration of the bone tissue.

关键词： Nano-biocomposite polycaprolactone Fluorapatite Bone tissue engineering Mechanical properties

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3D-printed Mg-1Ca/polycaprolactone composite scaffolds with promoted bone regeneration

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Journal of Magnesium and Alloys 2024年第3期12卷 966-979页

作者： Xiao Zhao Siyi Wang Feilong Wang Yuan Zhu Ranli Gu Fan Yang Yongxiang Xu Dandan Xia Yunsong Liu Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing 100081China National Center of Stomatology National Engineering Laboratory for Digital and Material Technology of StomatologyNational Clinical Research Center for Oral DiseasesBeijing Key Laboratory of Digital StomatologyResearch Center of Engineering and Technology for Computerized Dentistry Ministry of HealthNMPA Key Laboratory for Dental MaterialsBeijing 100081China Department of Dental Materials Peking University School and Hospital of StomatologyBeijing 100081China

In bone tissue engineering,polycaprolactone(PCL)is a promising material with good biocompatibility,but its poor degradation rate,mechanical strength,and osteogenic properties limit its *** this study,we developed an Mg-1Ca/polycaprolactone(Mg-1Ca/PCL)composite scaffolds to overcome these *** used a melt blending method to prepare Mg-1Ca/PCL composites with Mg-1Ca alloy powder mass ratios of 5,10,and 20 wt%.Porous scaffolds with controlled macro-and microstructure were printed using the fused deposition modeling *** explored the mechanical strength,biocompatibility,osteogenesis performance,and molecular mechanism of the Mg-1Ca/PCL *** 5 and 10 wt%Mg-1Ca/PCL composites were found to have good ***,they promoted the mechanical strength,proliferation,adhesion,and osteogenic differentiation of human bone marrow stem cells(hBMSCs)of pure *** vitro degradation experiments revealed that the composite material stably released Mg_(2)+ions for a long period;it formed an apatite layer on the surface of the scaffold that facilitated cell adhesion and *** tomography and histological analysis showed that both 5 and 10 wt%Mg-1Ca/PCL composite scaffolds promoted bone regeneration bone *** results indicated that the Wnt/β-catenin pathway was involved in the osteogenic ***,Mg-1Ca/PCL composite scaffolds are expected to be a promising bone regeneration material for clinical *** of significance:Bone tissue engineering scaffolds have promising applications in the regeneration of critical-sized bone ***,there remain many limitations in the materials and manufacturing methods used to fabricate *** study shows that the developed Ma-1Ca/PCL composites provides scaffolds with suitable degradation rates and enhanced boneformation ***,the fused deposition modeling method allows precise control of the macroscopic morphology and microsc

关键词： 3D printing Bone tissue engineering Magnesium Osteogenic polycaprolactone Scaffold.

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Thermally driven carbon nanotube@polycaprolactone coaxial artificial muscle fibers working in subzero environments

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International Journal of Smart and Nano Materials 2023年第2期14卷 216-229页

作者： Lizhong Dong Xulin Wei Ming Ren Jiangtao Di Advanced Materials Division Suzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhouChina Division of Nanomaterials and Jiangxi Key Lab of Carbonene Materials Jiangxi Institute of NanotechnologyNanchangChina Zhejiang Lab HangzhouChina

Artificial muscle fibers driven electrothermally with excellent properties of response,stroke,and work capacity are expected to serve in some intelligent structures and ***,muscle fibers that operate in subzero environments are highly needed in industrial production and aerospace applications but remain ***,we reported a coaxial artificial muscle fiber by electrospinning a sheath of polycaprolactone(PCL)nanofibers on the surface of a carbon nanotube(CNT)fiber core,achieving the actuation in response to thermal at subzero *** CNT@PCL coaxial muscle fiber under 0.3 MPa achieved a maximum contractile stroke of~18%as the temperature changed from−130℃ to 45℃.The actuation mechanism at subzero temperatures of this muscle fiber was analyzed in combination with the temperature-deformation schematic curve of different ***,a temperature sensor based on this muscle fiber was developed,due to the excellent linear relationship between the contraction and temperature.A 3D-printed prosthetic arm was designed to further exhibit the application demonstrations of this muscle fiber in subzero *** work provides new insights into artificial muscle fibers for serving in extreme environments with ultralow temperatures.

关键词： Artificial muscles thermally driven subzero environment carbon nanotubes polycaprolactone

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Electrospun Aloe Vera Extract Loaded polycaprolactone Scaffold for Biomedical Applications:A Promising Candidate for Corneal Stromal Regeneration

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Journal of Bionic Engineering 2024年第4期21卷 1949-1959页

作者： Amin Orash Mahmoud Salehi Mohammad Rafienia Narsimha Mamidi Saeed Heidari Keshel Alireza Baradaran-Rafii Department of Chemistry and Nanotechnology School of Engineering and ScienceTecnologico de MonterreyMonterreyNuevo Leon64849Mexico Biosensor Research Center Isfahan University of Medical SciencesIsfahan81746-73461Iran Wisconsin Center for NanoBioSystems School of PharmacyUniversity of Wisconsin-MadisonMadisonWisconsin53705USA Medical Nanotechnology Research Center Shahid Beheshti University of Medical SciencesTehran19857-17443Iran Department of Ophthalmology Ophthalmic Research CenterLabbafinejad Medical CenterShahid Beheshti University of Medical SciencesTehran19395-4631Iran Department of Ophthalmology Morsani College of MedicineUniversity of South FloridaTampaFL33612USA Department of Tissue Engineering and Applied Cell Science School of Advanced Technologies in MedicineShahid Beheshti University of Medical SciencesTehran19857-17443Iran

Corneal diseases,the second leading cause of global vision loss affecting over 10.5 million people,underscores the unmet demand for corneal tissue *** the scarcity of fresh donor corneas and the associated risks of immune rejection,corneal tissue engineering becomes *** nanofibrous scaffolds that mimic the natural corneal structure is crucial for creating transparent and mechanically robust corneal equivalents in tissue ***,Aloe Vera Extract(AVE)/polycaprolactone(PCL)nanofibrous scaffolds were primed using *** electrospun AVE/PCL fibers exhibit a smooth,bead-free morphology with a mean diameter of approximately 340±95 nm and appropriate light *** measurements reveal Young’s modulus and ultimate tensile strength values of around 3.34 MPa and 4.58 MPa,respectively,within the range of stromal *** addition,cell viability of AVE/PCL fibers was measured against Human Stromal Keratocyte Cells(HSKCs),and improved cell viability was *** cell-fiber interactions were investigated using scanning electron *** conclusion,the incorporation of Aloe Vera Extract enhances the mechanical,optical,hydrophilic,and biological properties of PCL fibers,positioning PCL/AVE fiber scaffolds as promising candidates for corneal stromal regeneration.

关键词： Corneal stromal regeneration Aloe vera extract polycaprolactone Electrospinning

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polycaprolactone strengthening keratin/ bioactive glass composite scaffolds with double cross-linking networks for potential application in bone repair

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Journal of Leather Science and Engineering 2022年第1期4卷 1-13页

作者： Liying Sun Shan Li Kaifeng Yang Junchao Wang Zhengjun Li Nianhua Dan National Engineering Research Center of Clean Technology in Leather Indus-try Sichuan UniversityChengduChina Key Laboratory of Leather Chemistry and Engineering of Ministry of Education Sichuan UniversityChengduChina

In this study, we aimed at constructing polycaprolactone (PCL) reinforced keratin/bioactive glass composite scaffolds with a double cross-linking network structure for potential bone repair application. Thus, the PCL-keratin-BG com-posite scaffold was prepared by using keratin extracted from wool as main organic component and bioactive glass (BG) as main inorganic component, through both cross-linking systems, such as the thiol-ene click reaction between abundant sulfhydryl groups of keratin and the unsaturated double bond of 3-methacryloxy propyltrimethoxy silane (MPTS), and the amino-epoxy reaction between amino groups of keratin and the epoxy group in (3-glycidoxymethyl) methyldiethoxysilane (GPTMS) molecule, along with introduction of PCL as a reinforcing agent. The success of the thiol-ene reaction was verified by the FTIR and 1H-NMR analyses. And the structure of keratin-BG and PCL-keratin-BG composite scaffolds were studied and compared by the FTIR and XRD characterization, which indicated the successful preparation of the PCL-keratin-BG composite scaffold. In addition, the SEM observation, and contact angle and water absorption rate measurements demonstrated that the PCL-keratin-BG composite scaffold has interconnected porous structure, appropriate pore size and good hydrophilicity, which is helpful to cell adhesion, differentiation and prolifera-tion. Importantly, compression experiments showed that, when compared with the keratin-BG composite scaffold, the PCL-keratin-BG composite scaffold increased greatly from 0.91 ± 0.06 MPa and 7.25 ± 1.7 MPa to 1.58 ± 0.21 MPa and 14.14 ± 1.95 MPa, respectively, which suggesting the strong reinforcement of polycaprolactone. In addition, the biomineralization experiment and MTT assay indicated that the PCL-keratin-BG scaffold has good mineralization abil-ity and no-cytotoxicity, which can promote cell adhesion, proliferation and growth. Therefore, the results suggested that the PCL-keratin-BG composite scaffold has the

关键词： Keratin Bioactive glass polycaprolactone Double cross-linking networks Bone regeneration

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Multidimensionally Nano‑topologized polycaprolactone Fibrous Membrane Anchored with Bimetallic Peroxide Nanodots for Microenvironment‑Switched Treatment on Infected Diabetic Wounds

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Advanced Fiber Materials 2024年第6期6卷 1777-1797页

作者： Lin Qi Yong Huang Zheng Liu Jiangshan Liu Jing Wang Huilun Xu Hao Yang Limin Liu Ganjun Feng Shuyu Zhang Yubao Li Li Zhang Analytical and Testing Center Sichuan UniversityChengdu 610065China Department of Orthopedic Surgery and Orthopedic Research Institute&West China Hospital Sichuan UniversityChengdu 610065China West China School of Basic Medical Science and Forensic Medicine Sichuan UniversityChengdu 610065China

Delayed healing of diabetic wounds poses a major challenge to human health due to severe vascular dysfunction,sustained inflammation,and vulnerability to microbial ***,we constructed multidimensionally nano-topologized elec-trospun polycaprolactone(PCL)fibrous membranes with shish-kebab nanoarrays on each fiber through self-induced crys-tallization,on which the CuO2-MgO2 bimetallic peroxide nanodots(BPNs)were anchored by polydopamine(PDA)as the bridging *** activated by the acidic microenvironment(typically infected diabetic wound),BPNs on fibers reacted immediately to release Cu2+and Mg2+ions together with hydrogen peroxide(H2O2)molecules,which were then transferred into·OH radicals through Fenton-type reactions catalyzed by Cu2+for instant bacteria *** the same time,the released Cu2+and Mg2+ions were retained to improve the angiogenesis and suppress the inflammation infiltration,thus remodeling the wound ***,the one-dimensional(1D)-constructed nano shish-kebabs and PDA coating on fibers provided additional topological activation for cell adhesion and directed migration along the aligned fiber *** the meticulous design,the resultant membranes markedly accelerated the infected wound healing in the diabetic rat *** study pioneers a unique design to develop a nanocomposite fibrous membrane that combines multidimensional topologies with chemodynamic therapy(CDT),for efficiently combating infected diabetic wounds.

关键词： Electrospinning polycaprolactone Multidimensional topology Metal peroxides Diabetic wound

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Enzymatic Synthesis of polycaprolactone:Effect of Immobilization Mechanism of CALB on polycaprolactone Synthesis

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Journal of Renewable Materials 2018年第6期6卷 619-629页

作者： Yasemin Kaptan.M.Sc Yüksel Avcıbaşı-Güvenilir Istanbul Technical University Department of Chemical EngineeringIstanbul Technical University34469Maslak-Istanbul

Surface-modified rice husk ash was used as an inorganic support material for immobilization of Candida antarctica lipase B.(3-aminopropyl)trimethoxysilane was used for surface *** of CALB was performed via both physical adsorption and *** synthesis was carried out by using these immobilized enzymes,free enzyme and Novozyme 435®.Molecular weight distribution of polymer samples was obtained by gel permeation chromatography(GPC)and chain structures of the polymer samples were observed by hydrogen nuclear magnetic resonance(1H-NMR).The highest monomer conversion is generally obtained by using cross-linked enzyme,around 90%.PDI values for all polymer samples were approximately 1.5 which can be considered as *** general cross-linked enzymes were better than physically adsorbed enzymes in terms of average molecular *** can be concluded that PCL can be synthesized with these immobilized enzymes with high molecular weight and low PDI values.

关键词： Candida antarctica lipase B cross-linking physical adsorption polycaprolactone rice husk ash

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The Accelerated Thermo-Oxidative Aging Characteristics of Wood Fiber/polycaprolactone Composite:Effect of Temperature,Humidity and Time

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Journal of Renewable Materials 2021年第12期9卷 2209-2222页

作者： Shuang Si Qian Tang Xingong Li Central South University of Forestry and Technology Changsha410004China

This study investigated the characteristics of wood fiber/polycaprolactone composite after an artificial accelerated thermo-oxidative aging *** effect of time,temperature and humidity during the treatment on their mechanical,chemical and morphology properties were *** composite was prepared from melted wood fibers and modified polycaprolactone by a molding process.A temperature and humidity controllable test chamber was used for the thermo-oxidative aging of the *** thermo-oxidative aging caused surface of the composite to be much more rougher and even a few cracks and holes appeared on *** to the spectra of Fourier Transform Infrared(FTIR)and Gel Permeation Chromatography(GPC),C=O in the molecular chain of polycaprolactone was hydrolyzed and C–O was broken after the aging treatment,which resulted in a reduction in average molecular weight of the ***,results showed that the mechanical strength decreased a lot with the increase in time,temperature and humidity,and the effect of temperature and humidity was more significant compared with that of *** the temperature and humidity during thermo-oxidative aging treatment could accelerate the aging of composite,which provided a quick and effective method for evaluating the aging resistance of the composite.

关键词： Wood fiber polycaprolactone wood plastic composite thermo-oxidative aging

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Three-dimensional-printed polycaprolactone scaffolds with interconnected hollow-pipe structures for enhanced bone regeneration

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Regenerative Biomaterials 2022年第1期9卷 471-479页

作者： Jiahua Duan Dong Lei Chen Ling Yufeng Wang Zhicheng Cao Ming Zhang Huikang Zhang Zhengwei You Qingqiang Yao Department of Orthopaedic Surgery Nanjing First HospitalNanjing Medical UniversityNanjing 210006China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Materials Science and EngineeringInstitute of Functional MaterialsDonghua UniversityShanghai 201620China Research Base of Textile Materials for Flexible Electronics and Biomedical Applications(China Textile Engineering Society) Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineShanghai 201620China Department of Cardiology Shanghai 9th People’s HospitalShanghai Key Laboratory of Tissue EngineeringSchool of MedicineShanghai Jiao Tong UniversityShanghai 200011China

Three-dimensional(3D)-printed scaffolds are widely used in tissue engineering to help regenerate critical-sized bone ***,conventional scaffolds possess relatively simple porous structures that limit the delivery of oxygen and nutrients to cells,leading to insufficient bone ***,in the present study,perfusable and permeable polycaprolactone scaffolds with highly interconnected hollow-pipe structures that mimic natural micro-vascular networks are prepared by an indirect onepot 3D-printing *** vitro experiments demonstrate that hollow-pipe-structured(HPS)scaffolds promote cell attachment,proliferation,osteogenesis and angiogenesis compared to the normal non-hollow-pipe-structured ***,in vivo studies reveal that HPS scaffolds enhance bone regeneration and vascularization in rabbit bone defects,as observed at 8 and 12weeks,***,the fabricated HPS scaffolds are promising candidates for the repair of critical-sized bone defects.

关键词： three-dimensional printing interconnected hollow-pipe structure bone regeneration vascularization polycaprolactone

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Unravelling the physicochemical and antimicrobial mechanisms of human serum albumin/tannic acid coatings for medical-grade polycaprolactone scaffolds

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Bioactive Materials 2024年第12期42卷 68-84页

作者： Silvia Cometta Bogdan C.Donose Alfredo Juarez-Saldivar Akhilandeshwari Ravichandran Yanan Xu Nathalie Bock Tim R.Dargaville Aleksandar D.Rakic Dietmar W.Hutmacher Faculty of Engineering School of MechanicalMedical and Process EngineeringQueensland University of TechnologyBrisbaneQLD4000Australia Australian Research Council Training Centre for Multiscale 3D Imaging Modelling and Manufacturing(M3D Innovation)Queensland University of TechnologyKelvin GroveQLD4059Australia Max Planck Queensland Centre Queensland University of TechnologyBrisbaneQLD4000Australia School of Electrical Engineering and Computer Science The University of QueenslandBrisbaneQLD4072Australia Unidad Academica Multidisciplinaria Reynosa Aztlan Universidad Autonoma de TamaulipasReynosa88740Mexico Central Analytical Research Facility(CARF) Queensland University of TechnologyBrisbaneQLD4000Australia Faculty of Health School of Biomedical SciencesQueensland University of TechnologyBrisbaneQLD4000Australia Translational Research Institute WoolloongabbaQLD4102Australia Centre for Materials Science School of Chemistry and PhysicsQueensland University of TechnologyBrisbaneQLD4000Australia Australian Research Council Training Centre for Cell and Tissue Engineering Technologies Queensland University of TechnologyBrisbaneQLD4059Australia

Biofilm-related biomaterial infections are notoriously challenging to treat and can lead to chronic infection and persisting *** date,a large body of research can be reviewed for coatings which potentially prevent bacterial infection while promoting implant *** only a very small number has been translated from bench to *** study provides an in-depth analysis of the stability,antibacterial mechanism,and biocompatibility of medical grade polycaprolactone(mPCL),coated with human serum albumin(HSA),the most abundant protein in blood plasma,and tannic acid(TA),a natural polyphenol with antibacterial *** docking studies demonstrated that HSA and TA interact mainly through hydrogen-bonding,ionic and hydrophobic interactions,leading to smooth and regular *** vitro bacteria adhesion testing showed that coated scaffolds maintained their antimicrobial properties over 3 days by significantly reducing *** colonization and biofilm ***,amplitude modulation-frequency modulation(AMFM)based viscoelasticity mapping and transmission electron microscopy(TEM)data suggested that HSA/TA-coatings cause morphological and mechanical changes on the outer cell membrane of *** leading to membrane disruption and cell death while proving non-toxic to human primary *** results support this antibiotic-free approach as an effective and biocompatible strategy to prevent biofilm-related biomaterial infections.

关键词： Bacterial infection Biofilm Human serum albumin Tannic acid polycaprolactone 3D printing Scaffold

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