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Toxicity Profile of Karuho poison on the Brain of Wistar Albino Rats

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Neuroscience & Medicine 2018年第2期9卷 63-80页

作者： Samuel Kule Kyolo Godfrey S. Bbosa John Odda Aloysius M. Lubega Ntabe Namegabe Edmond Department of Pharmacology & Therapeutics Makerere University College of Health Sciences Kampala Uganda Department of Medicine Faculty of Medicine Université Libre des Pays des Grands Lacs (ULPGL) Goma City DR Congo

Various forms of Karuho poisoning are a common traditional mystery and a public health challenge in Goma city, North Kivu in DRC practiced by unscrupulous people. Its signs and symptoms are commonly mistaken by local communities and medical world with those of tuberculosis, HIV/AIDS and typhoid fever;with neurological and psychological symptoms. Study investigated sub-acute toxicity of Karuho poison on brain of Wistar albino rats. Laboratory based experimental study was conducted at Department of Pharmacology & Therapeutics, Makerere University College of Health Sciences. A total of 4 Karuho poisons (OMGKRP, DLNKRP, CHKRP and BHKRP) were screened for acute and sub-acute toxicity. Fifty animals, 10 in each group were daily dosed for 28 days with 1 mg, 5 mg, 20 mg and 5000 mg/kg bwt of OMGKRP (most active following screening) and normal saline for control group using OECD 407 and NIH 2011 guidelines. Behavioral changes were noted. Histopathological changes in brain regions were analyzed. Treated rats by OMGKRP, most active Karuho poison, were associated with sign of depression, piloerection and shortness of breath. Histopathological changes revealed moderate diffuse congestion and mononuclear inflammatory cells infiltration (plasma cells, lymphocytes and macrophage) in cerebral region with severe inflammation observed in meninges of cerebellum. OMGKRP poison induced inflammation of meninges of cerebellar region of brain.

关键词： Karuho poison OMGKRP Brain Tissue and Sub-Acute Toxicity

Blood Chemistry and Major Body Organ Induced-Toxicity by Locally-Made Traditional OMGKRP Karuho poison in Wistar Albino Rats

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Neuroscience & Medicine 2019年第3期10卷 272-291页

作者： Samuel Kule Kyolo John Odda Aloysius Lubega Godfrey S. Bbosa Department of Pharmacy Provincial Hospital of North Kivu Goma DR. Congo Department of Pharmacology and Therapeutics Makerere University College of Health Sciences Kampala Uganda

OMGKRP is one of various Karuho poison mysteriously used by unscrupulous individuals to kill people during conflict and animals in Goma City, in DRC. The symptoms and signs of most cases are usually confused with many chronic diseases like tuberculosis and HIV/AIDS;with renal, hepatic and cardiac manifestations as well as blood chemistry changes. The study investigated the toxic effect of OMGKRP poison on blood chemistry, serum enzymes and organ toxicity including the kidney, lung, liver and heart of Wistar albino rats. A laboratory-based experimental study was conducted. Fifty animals in 5 groups each with 10 animals were dosed daily for 28 days with 1.0 mg, 5.0 mg, 20.0 mg and 5000.0 mg/Kg body weight of OMGKRP and normal saline as control group. International standard guidelines, OECD 407 and NIH 2011 were followed during the study period. The blood chemistry analysis, relative organ weight and histopathological changes in the kidney, lung, liver and heart were performed. The findings showed that OMGKRP was associated with increased blood chemistry parameters including total proteins, creatinine, urea, K+?levels, direct albumin levels, a decrease in Cl−?levels and albumin levels. Histopathological findings showed an increased relative weight and tissue damages of the lung, kidney, liver and heart. Therefore, OMGKRP Karuho poison caused toxicity on blood chemistry, serum enzymes as well as histopathological changes in the lung, renal, hepatic and cardiac tissue damages in Wistar albino rats.

关键词： Blood Chemistry Serum Enzymes OMGKRP Karuho poison Organ Toxicity Sub-Acute Toxicity

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进口宝马poison Ivy

黑客防线 2006年第9期 61-63页

作者：望海潮

应黑防VIP忘了忘了之约．为他“做”只宝马，翻遍了工具箱才发现真的验证了蝴蝶的一句话“冰河已经离我们远去，黑洞也不再继续，所以我们能够选择的国产木马只有灰鸽子和PcShare“。可既然已经夸下海口怎么能不算数呢？经过一段时间的... 详细信息

应黑防VIP忘了忘了之约．为他“做”只宝马，翻遍了工具箱才发现真的验证了蝴蝶的一句话“冰河已经离我们远去，黑洞也不再继续，所以我们能够选择的国产木马只有灰鸽子和PcShare“。可既然已经夸下海口怎么能不算数呢？经过一段时间的寻寻觅觅，终于请出了我们今天的主角．进口宝马poison Ivy2．0．0。

关键词：宝马 poison Ivy 工具箱灰鸽子木马

迪奥“poison”毒药香水20年的魅惑传奇

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旅游时代 2013年第5期 91-92页

作者：化春光

浓烈的魅惑战胜羞怯的情愫,以征服的欲望打碎传统的规则,这样的时刻、这样的胜利注定要惊世骇俗。20世纪80年代,奢侈品牌迪奥推出了旗下第一款"poison"毒药香水后,它那独出心裁的大胆命名和洋溢极致诱惑的香调即启开了长达20年的魅惑传... 详细信息

浓烈的魅惑战胜羞怯的情愫,以征服的欲望打碎传统的规则,这样的时刻、这样的胜利注定要惊世骇俗。20世纪80年代,奢侈品牌迪奥推出了旗下第一款"poison"毒药香水后,它那独出心裁的大胆命名和洋溢极致诱惑的香调即启开了长达20年的魅惑传奇。而后推出的TENDRE

关键词： poison 迪奥奢侈品牌华丝水瓶名字即浪漫气质生化危机时子在黑暗中

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编程免杀poison Ivy远控

黑客防线 2010年第3期 32-33页

作者： masepu

P0ison Ivy是一款非常有名的远控软件，体积小，功能全．相信很多人都用过它。但是木秀于林．风必摧之。由于其名气太大，导致各类杀毒软件都没有放过它。我下载了poisonlvy2．3．2版，服务端在生成时立即被杀毒软件杀掉，试了好几种杀... 详细信息

P0ison Ivy是一款非常有名的远控软件，体积小，功能全．相信很多人都用过它。但是木秀于林．风必摧之。由于其名气太大，导致各类杀毒软件都没有放过它。我下载了poisonlvy2．3．2版，服务端在生成时立即被杀毒软件杀掉，试了好几种杀软，无一例外，百分百被杀。我不会做EXE的免杀，

关键词：工具免杀 poison Ivy

Concept of dushi visha(latent poison)a review in ayurveda

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TMR Theory and Hypothesis 2019年第2期2卷 166-172页

作者： Dr.Deepti Patel Dr.S.R.Inchulkar Dr.YuvrajKaushik Dr.N.S.Chauhan Department of Agad Tantra Evam Vidhi Vaidyak Govt. Ayurveda CollegeRaipurIndia Senior Scientific Officer Grade-II Drug Testing Laboratory Avam Anusandhan Kendra RaipurIndia

A poison,which is having fewer properties,which means less thanit’s own ten classical properties or the poison which is having lesser potency of all ten properties,attains a accumulative or hidden stage in the body is called Dushi Visha(latent poison).Low potency of all the ten qualities of poison are said to be responsible for the delayed action and cumulative toxicity on the body.A much detailed description about DushiVisha is not seen in Ayurvedic *** concept of DushiVisha is still an *** understand Dushi Visha,it is important to understand that what are theoriginating factors can be considered under DushiVisha,how it remains in the body without undergoing elimination,how does it causes cumulative toxicity,which factors will aggravate DushiVisha,how the clinical features of DushiVisha will be presented in the *** get proper answer to all these practical queries,it is necessary to go through it’*** an attempt is made to review the concept of DushiVisha in detail.

关键词： DushiVisha Latent poison Virudhahara Cumulative toxicity

kill，poison，execute和slaughter辨异

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大学英语 1996年第12期 67-67页

作者：刘明东张治英

ｋｉｌ，ｐｏｉｓｏｎ，ｅｘｅｃｕｔｅ和ｓｌａｕｇｈｔｅｒ辨异刘明东张治英《大学英语》精读（复旦大学编）第三册中出现的ｋｉｌ，ｐｏｉｓｏｎ，ｅｘｅｃｕｔｅ和ｓｌａｕｇｈｔｅｒ四个动词，其共性为ｍａｋｅｄｅａｄ，但在具体... 详细信息

ｋｉｌ，ｐｏｉｓｏｎ，ｅｘｅｃｕｔｅ和ｓｌａｕｇｈｔｅｒ辨异刘明东张治英《大学英语》精读（复旦大学编）第三册中出现的ｋｉｌ，ｐｏｉｓｏｎ，ｅｘｅｃｕｔｅ和ｓｌａｕｇｈｔｅｒ四个动词，其共性为ｍａｋｅｄｅａｄ，但在具体的用法上各有不同，现辨别如下：１．...

关键词：《大学英语》刘明东 poison slaughter execute

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兴奋剂的种类、毒性和副作用

成都体育学院学报 1992年第3期18卷 88-92页

作者：谭进毕新奇杨幼之成都体育学院解剖教研室成都地质学院

兴奋剂的范围很广,违禁药物是兴奋剂的一部分,国际奥委会医务委员会到1991年底公布的违禁药物计五大类100种。这五大类是刺激剂、麻醉止痛剂、合成类固醇、β—阻断剂和利尿剂,以及血液兴奋剂。运动员使用这些违禁药物在竞赛中能获得非... 详细信息

兴奋剂的范围很广,违禁药物是兴奋剂的一部分,国际奥委会医务委员会到1991年底公布的违禁药物计五大类100种。这五大类是刺激剂、麻醉止痛剂、合成类固醇、β—阻断剂和利尿剂,以及血液兴奋剂。运动员使用这些违禁药物在竞赛中能获得非法利益,但滥用药物对于身体健康的运动员危害极大。本文就违禁药物的种类、各类药物的作用机理、毒性和副作用作了较全面的介绍。

关键词： poison Side effects Doping Category

The Conidae Family (Snails Producers of poisons) Associated with the Rocky Intertidal Zone of Acapulco, Mexico

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Natural Resources 2014年第8期5卷 343-350页

作者： Rafael Flores-Garza Yareni M. Garcia-Moctezuma Pedro Flores-Rodríguez Jesús E. Michel-Morfín Carmina Torreblanca-Ramírez Departamento de Estudios para el Desarrollo Sustentable de Zonas Costeras Universidad de Guadalajara Jalisco Mexico Laboratorio de Ecología Costera y Sustentabilidad Unidad Académica de Ecología Marina Universidad Autónoma de Guerrero Acapulco Mexico Unidad de Ciencias de Desarrollo Regional Universidad Autónoma de Guerrero Acapulco Mexico

Acapulco, Mexico has a coastline of 62 km where large areas of rocky substrate inhabited by organisms such as the GASTROPODA Class can be found. Conidae (Fleming, 1822) Family is among the members of this Class, which has been poorly studied in the Mexican Pacific, despite their biomedical potential. This research was carried out in the rocky intertidal of nine sites in Acapulco. The objectives were: 1) Prepare an inventory of species associated with rocky intertidal of Conidae family, 2) examine the composition of the family based on two criteria: a) species richness and b) abundance, 3) determine the geographical distribution and 4) analyze the size composition. The unit sampled was 1 m2 and the sampled area was 10 m2 persite. A total of 97 organisms were analyzed, corresponding to two subfamilies, five genera and five species. The Puncticuliinae (Tucker & Tenorio, 2009) subfamily had higher species richness, abundance and frequency of occurrence. The most abundant and most common species were Harmoniconus nux (Broderip, 1833) and Gladioconus gladiator (Broderip, 1833) both showed regular distribution. The size structure found for Conidae family is similar to what has been reported in other research. For the first time G. gladiator is being reported for the state of Guerrero.

关键词： Conidae Acapulco poison Distribution Rocky Intertidal Zone