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Routine blood tests to predict liver fibrosis in chronic hepatitis C

World Journal of Gastroenterology 2012年第8期18卷 746-753页

作者： Yung-Yu Hsieh Shui-Yi Tung Cheng-Shyong Wu Kuo- Liang Wei Chien-Heng Shen Te-Sheng Chang Kamfai Lee Yi-Hsiung Lin Department of Gastroenterology and Hepatology Chang Gung Memorial Hospital Chiayi 613 Taiwan Chang Gung University College of Medicine Taoyuan 333 Taiwan Chiayi School ChangOung Institute of Technology Chiayi 613 Taiwan Department of Pathology Chang Gung MemorialHospital Chiayi 613 Taiwan Department of Health Care Administration Taiwan Shoufu University Tainan 721 Taiwan

AIM: To verify the usefulness of FibroQ for predicting fi brosis in patients with chronic hepatitis C, compared with other noninvasive tests. METHODS: This retrospective cohort study included 237 consecutive patients with chronic hepatitis C who had undergone percutaneous liver biopsy before treatment. FibroQ, aspartate aminotransferase (AST)/alanine aminotransferase ratio (AAR), AST to platelet ratioindex, cirrhosis discriminant score, age-platelet index (API), pohl score, FIB-4 index, and Lok's model were calculated and compared. RESULTS: FibroQ, FIB-4, AAR, API and Lok's model results increased significantly as fibrosis advanced (analysis of variance test: P score in chronic hepatitis C compared with other noninvasive tests. CONCLUSION: FibroQ is a simple and useful test for predicting signifi cant fi brosis in patients with chronic hepatitis C.

关键词： Liver fibrosis Noninvasive test FibroQ Aspartate aminotransferase, Alanine aminotransferase FIB-4 index Aspartate aminotransferase to plateletratio index Lok's model Cirrhosis discriminant score pohl score

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Noninvasive assessment of hepatic fibrosis in Egyptian patients with chronic hepatitis C virus infection

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World Journal of Gastroenterology 2012年第23期18卷 2988-2994页

作者： Shawky Abdelhamid Fouad Serag Esmat Dalia Omran Laila Rashid Mohamed H Kobaisi Department of Internal Medicine Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Tropical Medicine Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Biochemistry Faculty of Medicine Cairo University Cairo 11562 Egypt Department of Pathology National Institute of Nephrology Cairo 35789 Egypt

AIM: To evaluate the accuracy of specific biochemical markers for the assessment of hepatic fibrosis in patients with chronic hepatitis C virus (HCV) infection. METHODS: One hundred and fifty-four patients with chronic HCV infection were included in this study; 124 patients were non-cirrhotic, and 30 were cirrhotic. The following measurements were obtained in all patients: serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin, total bilirubin, prothrombin time and concentration, complete blood count, hepatitis B surface antigen (HBsAg), HCVAb, HCV-RNA by quantitative polymerase chain reaction, abdominal ultrasound and ultrasonic-guided liver biopsy. The following ratios, scores and indices were calculated and compared with the results of the histopathological examination: AST/ALT ratio (AAR), age platelet index (API), AST to platelet ratio index (APRI), cirrhosis discriminating score (CDS), pohl score, G teborg University Cirrhosis Index (GUCI). RESULTS: AAR, APRI, API and GUCI demonstrated good diagnostic accuracy of liver cirrhosis (80.5%, 79.2%, 76.6% and 80.5%, respectively); P values were: 0.05). In addition, we found significant correlations for the AAR, APRI, API, GUCI and pohl score between the non-cirrhotic (F0, F1, F2, F3) and cirrhotic (F4) groups (P values: 0.05). CONCLUSION: The use of AAR, APRI, API, GUCI and pohl score measurements may decrease the need

关键词： Age platelet index Aspartate aminotrans-ferase platelet ratio index Aspartate aminotransferase-to-alanine aminotransferase ratio Cirrhosis discrimi-nating score Fibrosis evaluation G^teborg UniversityCirrhosis Index Hepatitis C virus infection Liver fibro-sis pohl score

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