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Pulsatile core-in-cup valsartan tablet formulations:In vitro evaluation

Asian Journal of Pharmaceutical Sciences 2013年第4期8卷 234-243页

作者： M.S.Sokar A.S.Hanafy A.H.El-Kamel S.S.El-Gamal pharmaceutics department faculty of pharmacyalexandria universityalexandriaegypt pharmaceutics department faculty of pharmacy and drug manufacturingpharos universityalexandriaegypt

The aim of the present study was to design and evaluate single pulse and floating double pulse valsartan core-in-cup *** tablets were prepared by direct compression of a homogenous mixture of valsartan,Avicel PH-101,Croscarmellose sodium(CCNa),magnesium stearate&*** variation,Hardness and Disintegration time were measured for the core ***-in-cup tablets were formulated using different polymers as a plug layer,including sodium alginate(SA),sodium carboxymethylcellulose(NaCMC)and hydroxypropyl methyl cellulose(HPMC).The floating behavior,water uptake and drug release from the prepared formulations were *** Scanning Calorimetry(DSC)was also performed to detect the possible drug excipient *** study of the selected formula was performed at 25C&60%RH and at 40C&75%RH for 3 ***,the existence of the selected formula in the stomach after oral administration to human volunteers was verified via x-ray *** results showed that the release lag time of the tablets increased when the quantity of the plug layer increased thus decreasing the drug *** layer polymers showed a lag time with rank order:SAplug polymer)released valsartan after a lag time of 2 h while F6 released the drug in two successive pulses with a reasonable lag time in between due to its floating *** were stable for at least 3 months under standard long-term and accelerated storage *** conclusion,pulsatile single pulse and floating double pulse stable valsartan core-incup tablets were successfully formulated which provided a desirable lag time followed by a rapid drug release.

关键词： Core-in-cup tablets plug layer Lag time Floating Double pulse

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