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Nature’s marvels endowed in gaseous molecules Ⅰ:Carbon monoxide and its physiological and therapeutic roles

Acta Pharmaceutica Sinica B 2021年第6期11卷 1434-1445页

作者： Xiaoxiao Yang Wen Lu Christopher P.Hopper Bowen Ke Binghe Wang Department of Chemistry and Center for Diagnostics and Therapeutics Georgia State UniversityAtlantaGA 30303USA Institut für Experimentelle Biomedizin Universit?tsklinikum WürzburgBavaria 97080Germany Department of Anesthesiology West China HospitalChengdu 610041China

Nature has endowed gaseous molecules such as O_(2),CO_(2),CO,NO,H2 S,and N2 with critical and diverse roles in sustaining life,from supplying energy needed to power life and building blocks for life ’s physical structure to mediating and coordinating cellular *** this article,we give a brief introduction of the complex functions of the various gaseous molecules in life and then focus on carbon monoxide as a specific example of an endogenously produced signaling molecule to highlight the importance of this class of *** past twenty years have seen much progress in understanding CO’s mechanism(s) of action and pharmacological effects as well as in developing delivery methods for easy *** remarkable trait of CO is its pleiotropic effects that have few parallels,except perhaps its sister gaseous signaling molecules such as nitric oxide and hydrogen *** review will delve into the sophistication of CO-mediated signaling as well as its validated pharmacological functions and possible therapeutic applications.

关键词： Carbon monoxide Gasotransmitter Gaseous signaling molecule CO releasing molecule Organic CO prodrug Homeostasis pleiotropic effect Yin and Yang

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Genetic Architecture of Natural Variation in Rice Chlorophyll Content Revealed by a Genome-Wide Association Study

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Molecular Plant 2015年第6期8卷 946-957页

作者： Quanxiu. Wang Weibo Xie Hongkun Xing Ju Yan Xiangzhou Meng Xinglei Li Xiangkui Fu Jiuyue Xu Xingming Lian Sibin Yu Yongzhong Xing Gongwei Wang National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070China

Chlorophyll content is one of the most important physiological traits as it is closely related to leaf photo- synthesis and crop yield potential. So far, few genes have been reported to be involved in natural variation of chlorophyll content in rice （Oryza sativa） and the extent of variations explored is very limited. We con- ducted a genome-wide association study （GWAS） using a diverse worldwide collection of 529 O. sativa accessions. A total of 46 significant association loci were identified. Three F2 mapping populations with parents selected from the association panel were tested for validation of GWAS signals. We clearly demon- strated that Grain number, plant height, andheading date7 （GhdT） was a major locus for natural variation of chlorophyll content at the heading stage by combining evidence from near-isogenic lines and transgenic plants. The enhanced expression of Ghd7 decreased the chlorophyll content, mainly through down- regulating the expression of genes involved in the biosynthesis of chlorophyll and chloroplast. In addition, Narrow leaf1 （NAL1） corresponded to one significant association region repeatedly detected over two years. We revealed a high degree of polymorphism in the 5＇ UTR and four non-synonymous SNPs in the cod- ing region of NAL1, and observed diverse effects of the major haplotypes. The loci or candidate genes iden- tified would help to fine-tune and optimize the antenna size of canopies in rice breeding.

关键词： chlorophyll GWAS Ghd7 NAL 1 pleiotropic effect Oryza sativa

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Immunological Aspects of the Statins' Function in Patients with Heart Failure:A Report from the Annual Conference of ESC-Heart Failure 2005

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Cellular & Molecular Immunology 2005年第6期2卷 433-437页

作者： Maciej Banach Jarostaw Drozdz Piotr Okonski Jacek Rysz Department of Cardiac Surgery University Hospital No 3 in LodzMedical University in LodzPoland Medical University Hospital No.2 in Lodz Medical University of LodzPoland Department of Cardiac Surgery Medical University of LodzPolandSterlinga St.1/3 91-425 Lodz Poland The 2nd Department of Cardiology and Cardiac Surgery Bieganski Hospital in LodzMedical University in LodzPoland The 2nd Department of Family Medical University Hospital No.2 in Lodz Medical University of LodzPoland

The annual meeting of the Heart Failure Association of ESC in Lisbon, in June 2005, was exceptionally successful. There were many very interesting presentations and workshops with the unique rifle： Statins in heart failureCholesterol-lowering is not the only goal. Heart failure （HF） is a progressive disease with coronary artery disease （CAD） as the most often underlying etiology. Treatment to prevent progression of heart failure has been targeted to reverse the consequences of HF and to a less extent the cause - the atherosclerotic plaque itself. On the average 50% of patients with heart failure are treated with lipid intervention. Lipid-lowering treatment with statins clearly reduces morbidity and mortality of patients with documented CAD. Since the prevalent etiology of heart failure is CAD, its prevention may reduce heart failure progression. However, recent studies suggest that pleiotropic effects of statins are more important than the influence related to their cholesterol lowering mechanism. Furthermore it is suggested that low levels of circulating lipoproteins and cholesterol may be independent predictors of impaired outcome in patients with heart failure. There are some possible explanations for this finding. High levels of cholesterol can be beneficial to heart failure patients; cholesterol-rich serum lipoproteins are able to modulate inflammatory immune function because they bind and detoxify bacterial lipopolysaccharide, a very strong stimulator of the release of proinflammatory cytokines that promote heart failure progression and death. So current recommendations strongly emphasize that the aim of treatment of HF is not to lower cholesterol. Cellular ＆ Molecular Immunology. 2005;2（6）：433-437.

关键词： heart failure hypothesis statins pleiotropic effect

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Additive and additive × additive interaction make important contributions to spikelets per panicle in rice near isogenic (Oryza sativa L.) lines

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Journal of Genetics and Genomics 2010年第12期37卷 795-803页

作者： Qin He Kexin Zhang Caiguo Xu Yongzhong Xing National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan) Huazhong Agricultural University Wuhan 430070 China

Epistasis plays an important role in the genetic basis of rice yield traits. Taking interactions into account in breeding programs will help the development of high-yielding rice varieties. In this study, three sets of near isogenic lines （NILs） targeting three QTLs for spikelets per panicle （SPP）, namely qSPP1, qSPP2 and qSPP7, which share the same Zhenshan 97 genetic background, were used to produce an F 2 population in which the three QTLs segregated simultaneously. The genotypes of the individual F 2 plants at the three QTLs were replaced with three markers that are closely linked to the corresponding QTLs. These QTLs were validated in the F 2 and F 3 populations at the single marker level. qSPP7 exhibited major pleiotropic effects on SPP, plant height and heading date. Multifactor analysis of variance was performed for the F 2 population and its progeny. Additive × additive interaction between qSPP2 and qSPP7 had significant effects on SPP in both the F 2 population and its progeny. Both additive and additive × additive interactions could explain about 73% of the total SPP phenotypic variance. The SPP performance of 27 three-locus combinations was ranked and favorable combinations were rec- ommended for rice breeding in different ecosystems.

关键词： QTL validation phenotypic variance pleiotropic effect favorable combination

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Mapping of the genetic determinant for grain size in rice using a recombinant inbred line(RIL) population generated from two elite indica parents

Mapping of the genetic determinant for grain size in rice us...

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广东省遗传学会第九届代表大会暨学术研讨会

作者：刘迪林 Meihua Kang 王丰 Wuge Liu Chongyun Fu Jinhua Li Manshan Zhu Xueqin Zeng Yilong Liao Zhenrong Liu Huijun Huang Rice Research Institute Guangdong Academy of Agricultural Sciences Guangdong Provincial Key Laboratory of New Technology in Rice Breeding

Grain size is a major component of rice grain yield and grain *** we conducted genetic analysis for grain size using an F recombinant inbred lines(RILs)population derived from the cross between two elite indica parents,the slender-grain line Taifeng B(TFB) with good grain quality and the high-yielding short-grain cultivar Tesanai 2(TSA2).Strong positive association between hundred-grain weight and grain width was observed,but significant negative correlation was found between grain length and grain width.A total of 31 QTLs for grain weight,grain length,grain width,grain length/width ratio and grain thickness were identified and they explained a total phenotypic variance ranging from 51.4%to 73.8%.Of them,9 QTLs were reported for the first time and they are likely novel genetic ***,QTLs for grain size tend to form clusters at similar *** of them were detected on chromosome 3,5,and 7,locating at the regions of the previously reported loci GS3,qSW5IGW5 and GS7,*** allele variance of the above three loci between the parental lines was verified by using functional marker and genome *** major QTLs and QTL clusters discovered in this study are valuable for improvement of rice grain yield and quality through marker-assisted selection(MAS).The repeatedly detected QTLs and newly identified loci provide foundation for further fine mapping and map-based cloning.

关键词： Rice(Oryza sativa L) grain size QTL mapping pleiotropic effect marker-assisted selection(MAS)

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