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中国药理学通报 2015年第B11期31卷 142-143页

Fibrosis is a phenomenon of fibrous connective tissue increase in the organs. Activated hepatic stellate cells （HSCs） are the preferred targets of anti-hepatic fibrotic therapies. Ginseng and platycodon grandiflorum are impor- tant traditional Chinese medicine herbs. The study was to investigate the anti-fibrosis effects of ginseng extract and platycodon grandiflorum extract in HSCs. Extract include Ginseng water extract and alcohol extract, platycodon gran- diflorum water extract and alcohol extract, combination of both water extract and alcohol extract. Activated hepatic stellate cells were treated with Ginseng and platycodon grandiflorum extracts for 24h. The maximum concentration of the drug is 2000 mg · L^-1, the lowest concentration of 7.8 mg · L^-1 , with concentration gradient dilution. 3-（4 , 5- dimethylthiazol-2-yl）-2, 5-diphenylte-trazolium bromide （MTT） can evaluate the survival rate of cells. The expres- sions of SIRT1, NF-KB and p53 were detected by western blot. The results showed that extract effectively decreased the HSC cells viability in concentration dependent manner. Among them, the effect of combination of both extract is best. Ginseng and platycodon grandiflorum activated the protein expressions of SIRT1 in activated HSCs. The expres- sion of NF-KB and p53 were significantly decreased by Ginseng and platycodon grandiflorum. This study demonstrated that ginseng extract and platycodon grandiflorum extract showed obviously anti-fibrosis effect, and decreased expres-sion of NF-KB and p53 via SIRT1 signaling pathway.

关键词： hepatic fibrosis ginseng platycodon grandiflorum HSCs SIRT1 p53

Enhancement of Power Generation in Microbial Fuel Cells through Supplementation of <i>platycodon grandiflorum</i>in Doraji Roots

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Journal of Sustainable Bioenergy Systems 2019年第4期9卷 169-178页

作者： Jung-In Park Hyunjin Kim Dae Kyung Go Peter S. Park Sang Heon Lee Min Jung Koh Jonathan Jo Donghoon Lee Seungshin Lee Paul S. Chung Fuzbien Technology Institute Rockville MD USA Youth with Talents Fairfax VA USA St. Johnsbuury Academy Jeju Korea Department of Biology School of Arts and Sciences Cornell University Ithaca NY USA School of Arts and Sciences Johns Hopkins Baltimore MD USA

The current study reports the evidence of enhancement in power generation from cellulosic biomass in microbial fuel cell (MFC) systems by supplementing dried Doraji (platycodon grandiflorum) roots powder. Mediator-less two chamber H-type MFCs were prepared using rumen fluid as anode inocula to convert finely ground pine tree (Avicel) at 2% (w/v) to electricity. Dried Doraji roots were ground to pass 1 mm sieve and added to the anode of MFC at 0.1% w/v dosage for treatment. MFC power and current across an external resistor were measured daily for 10 d. At the end of incubation on d10, collected gases were measured for total gas volume and analyzed for gas composition on gas chromatography. Supplementation of Doraji roots powder to MFC anode chamber increased power generation and CO2 production. Over the 10d experimental period, power density normalized to anode surface area were between 17.0 and 37.7 with average of 32.5 mW/m2 in Doraji MFCs, and between 16.8 and 19.8 with average of 18.2 mW/m2 in control group. CO2 production increased and methane to CO2 ratio decreased in Doraji root treatment comparing to control group. These observations imply that Doraji root components would inhibit methanogenesis and alter microbial fermentation of cellulose compounds favorable to produce bioenergy efficiently in MFC.

关键词： MFC platycodon grandiflorum

Changes of respiratory function on urine volume, renal AQP1, and AQP2 in mice with bronchial asthma and effects of lung-diffusing herb platycodon grandiflorus (JACQ.) ***.

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Journal of Traditional Chinese Medical Sciences 2018年第1期5卷 72-79页

作者： Min Wang Yan Sun Fengjie Zheng Yushan Gao Shujing Zhang Yanan Wei Pengna Zhao Yixi Jin Yuhang Li Beijing University of Chinese Medicine Beijing 100029China

Objective:To observe the effect of respiratory-function changes on urinary output and expression of aquaporin (AQP) in kidney tissue in bronchial asthma (BA) model *** explore the correlation between the lung controlling breathing and the lung regulating the waterways,and observe regulation by the lung-diffusing herb platycodon root (platycodon grandiflorus (JACQ.) ***.).Methods:Forty-five healthy female Balb/c mice were divided randomly into normal,model and platycodon root *** BA model was replicated by complex sensitization and stimulation with ovalbumin (OVA).Changes in airway resistance were detected using an AniRes2005 system,and 24-hour urine output collected by metabolic *** changes in the lung and kidney were observed by H&rE *** of the mRNA of AQP1 and AQP2 was detected by reverse transcription-polymerase chain reaction,immunohistochemistry,and ***:Compared with the normal group,airway resistance in the inspiratory phase intensified in the model group (P platycodon root ***:Changes in respiratory function in BA model mice can affect how the lung regulates water *** root diffusing the lung can ameliorate the respiratoryfunction and pathologic changes in the lung tissues of BA model mice,but also regulate urinary output and renal expression of AQP1 and AQP2.

关键词： Bronchial asthma The lung controlling breathing Regulation of water pathways platycodon grandiflorus (JACQ.)A.DC. Aquaporin

Lodging-Resistance Breeding of platycodon grandiflorus Using Distant Hybridization

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American Journal of Plant Sciences 2015年第18期6卷 2844-2849页

作者： Yan Ma Yan Lin Huali Zhang Fang Liang Liping Sun Maoliang Wang Haibo Xin Beijing Institute of Landscape and Architecture Beijing Key Laboratory of Green Plants Breeding Beijing China

The distant hybridization was used in lodging-resistance breeding of platycodon grandiflorus. The parents were platycodon grandiflorus (♀) and Campanula medium (♂). 187 seeds of F1 were harvested by using the inter-generic hybridization in 2009 and 2010, 2 repeat, and 88 normal plants were obtained. The characteristics of leaves, stems and branches were the same as female for F1 generation, F2 generation, backcross generation and S1 generation, and there were some different characteristics with female which were flower colors, branching habit and plant height. A lodging-resistance plant was selected in F1, which was about 75 cm high, deep pink flower color and developed lateral branches. The DNA groups of each generation were separated by 1% agarose gel electrophoresis and there were not significant differences. Among the each generation many flower colors and forms were obtained.

关键词： Lodging-Resistance Breeding platycodon grandiflorus Campanula medium Distant Hybridization

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桔梗吸肥规律研究

桔梗吸肥规律研究

作者：李松吉林农业大学

学位级别：硕士

桔梗以根茎入药,主要活性成分为桔梗皂苷,广泛应用于咳嗽痰多、胸闷不畅、咽痛、音哑,肺痛吐脓、疱疹脓咽喉疾病、急性腰扭伤等症,桔梗苍耳煎可以有效的治疗鼻炎,而以桔梗为主开发出的常春茶具有益气养颜、活血化瘀、理气运脾之功效,是... 详细信息

桔梗以根茎入药,主要活性成分为桔梗皂苷,广泛应用于咳嗽痰多、胸闷不畅、咽痛、音哑,肺痛吐脓、疱疹脓咽喉疾病、急性腰扭伤等症,桔梗苍耳煎可以有效的治疗鼻炎,而以桔梗为主开发出的常春茶具有益气养颜、活血化瘀、理气运脾之功效,是保健和抗衰老的佳品。为了弄清楚桔梗的生长发育和吸肥规律,揭示其在不同生长发育阶段对氮、磷、钾及铜、铁、锰等营养元素的需求特点,我们以黑土为供试土壤,以3年生桔梗为试验材料,分别调查桔梗的生长发育规律和桔梗在各生育期内对各营养元素的需求规律。结果表明:6月中旬至10月上句,经调查发现4月上旬至4月中旬开始萌芽;4月下旬至5月上旬开始出苗;5月上旬至5月下旬大多数已完全展叶,叶色嫩绿;6月初时极少植株开始现蕾,6月初时开始有极少植株开花为初花期,6月下旬至7月下旬大部分都已开花为盛花期,从8月中下旬开始有少数花朵凋谢,开始进入末花期;9月初至9月中旬花朵大部分都已凋落。10月上旬至10月中旬地上植株开始萎谢。桔梗全株中,根茎中的氮、磷、钾含量分别在地上部营养生长期及枯萎期有较大的波动,并且含量都有明显的升高,经过生育中期含量的降低在枯萎期含量又出现明显的升高。在长春地区,氮在7月10日～7月17日是第一个吸收高峰期,磷则在6月26日～7月3日,磷则在7月3日～7月10日是第一个吸收高峰期;氮、磷在8月28日-9月4日时均出现了第二个吸收高峰期;钾在9月18日～9月25日出现了第二次非常明显的吸收高峰期,7月24日～8月28日之间吸收量均较低且变化较小,结果表明,地上部分快速生长期、枯萎期是桔梗营养吸收的高峰期;根据其营养特点,除一次性施足底肥外,以后在8月中旬第二次吸收高峰期来临前为最佳追肥期。

关键词：桔梗花 platycodon 枯萎期含量变化规律桔梗科植物咳嗽痰多营养生长期生长发育阶段快速生长期需求规律

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桔梗的用途和其栽培种植技术的应用

黑龙江医药 2014年第3期27卷 575-577页

作者：崔振刚

桔梗（platycodon grandiflorum（Jacp）***.）为桔梗科、桔梗属多年生草本植物，别名灯龙棵、包袱花根、苦桔梗、玉桔梗。属多年生双子叶草本，花期7～9月，果期8～l0月。具有宣肺祛痰、利咽、排脓的功效，主治外感咳嗽、胸满肋痛、痢... 详细信息

桔梗（platycodon grandiflorum（Jacp）***.）为桔梗科、桔梗属多年生草本植物，别名灯龙棵、包袱花根、苦桔梗、玉桔梗。属多年生双子叶草本，花期7～9月，果期8～l0月。具有宣肺祛痰、利咽、排脓的功效，主治外感咳嗽、胸满肋痛、痢疾腹痛，为常用中药材。桔梗不仅是一种传统中药，也是我国东北地区及日、韩等东亚国家的常用蔬菜之一，是一种很好的功能性食品。近年来，日本学者发现将桔梗提取物用于化妆品和浴液，具有独特的护肤抗衰老作用。桔梗为桔梗科多年生草本植物桔梗的根。主产于我国安徽、江苏、山东等地。东北、华北、华东、华中各省以及广东、广西（北部）、贵州、云南东南部（蒙自、砚山、文山）、四川（平武、凉山以东）、陕西。朝鲜、日本、苏联的远东和东西伯利亚地区的南部也有。桔梗于每年春、秋两季采挖，尤以秋季的质量最好，经清洗、晒干后入药。全国南北大多数省区均可以种植。桔梗喜温暖湿润、阳光充足的环境，气温20℃时适宜其生长。一般土壤均能种植，以沙壤土最好。一般为春秋播种。亩用种子1.5-2公斤。一年亩产150公斤干货，干鲜货为1：4.5，二年亩产300公斤干货，干鲜货：1：4。采收储藏：春、秋季采挖根，除去茎叶及须根，洗净泥土，刮去栓皮，晒干，切片备用。炮制：拣净杂质，除去芦头，洗净捞出，润透后切片，晒干。

关键词：桔梗花东亚国家 platycodon 苦桔梗常用中药材双子叶草外感咳嗽多年生草本桔梗属

张家口地区的野生桔梗科药用植物(药用植物普查报告之二)

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神经药理学报 1989年第3期 43-44页

作者：姜希强

张家口地区.桔梗科Campamulaceae的野生药用植物,经过全面普查共发现了四属十七种。一、桔梗属platycodon A、DC、桔梗P、grandiflorum(Jacg)A、DC、根入药。分布:生长在赤城、涿鹿、怀来、阳原、蔚县的山地草原及草甸。开发:蓄产量不大... 详细信息

张家口地区.桔梗科Campamulaceae的野生药用植物,经过全面普查共发现了四属十七种。一、桔梗属platycodon A、DC、桔梗P、grandiflorum(Jacg)A、DC、根入药。分布:生长在赤城、涿鹿、怀来、阳原、蔚县的山地草原及草甸。开发:蓄产量不大,怀来,涿鹿等少数山区已开发利用。

关键词：药用植物桔梗科张家口地区 platycodon 山地草原普查报告稀有种党参属怀来风铃草

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庭院桔梗的栽培与开发利用

特种经济动植物 2016年第8期19卷 43-45页

作者：金贤子严文岱刘冰抚顺市农业特产学校辽宁抚顺113000

桔梗[platycodon gradiflorus（Jacq）***]又名包袱花、白药、铃铛花、梗草、苦梗、苦桔梗、道拉基等,为桔梗科桔梗属多年生宿根草本植物,既适合大面积陆地栽培,也适合庭院栽培和盆栽。桔梗因其特有的经济价值和广布种的特点而倍受人们... 详细信息

桔梗[platycodon gradiflorus（Jacq）***]又名包袱花、白药、铃铛花、梗草、苦梗、苦桔梗、道拉基等,为桔梗科桔梗属多年生宿根草本植物,既适合大面积陆地栽培,也适合庭院栽培和盆栽。桔梗因其特有的经济价值和广布种的特点而倍受人们的青睐。近年来,由于野生桔梗频遭采挖,资源遭到破坏,为了保护野生资源,保持资源的恒定性和永久性,采用变野生为家植是使桔梗全面繁殖、

关键词：桔梗花庭院栽培 platycodon 苦桔梗苦梗包袱花广布种梗草桔梗属铃铛花