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Preoperative Neutrophil lymphocyte ratio and platelet lymphocyte ratio Cannot Predict Lymph Node Metastasis and Prognosis in Patients with Early Gastric Cancer:a Single Institution Investigation in China

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2018年第1期38卷 78-84页

作者： Guang-sheng ZHU Shao-bo TIAN Hui WANG Mao-guang MA Ya LIU Han-song DU Yue-ping LONG Department of Gastrointestinal Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Shanghai Institute of Rheumatology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200020China

In the present study,we aimed at exploring the applied value of preoperative neutrophil lymphocyte ratio(NLR)and platelet lymphocyte ratio(PLR)in the prediction of lymph node metastasis(LNM)and prognosis in patients with early gastric cancer(EGC).We retrospectively analyzed a total of 248 consecutive patients who underwent curative gastrectomy to be identified T1 stage gastric adenocarcinoma between January 1,2010 and May 1,2016 in a single *** to median preoperative NLR and PLR value,we divided the patients into four groups:high NLR≥1.73 and low NLR〈1.73,high PLR≥117.78 and low PLR〈***,to evaluate the relationship between preoperative NLR and PLR values,we categorized patients according to cutoff preoperative NLR-PLR score of 2[high NLR(≥1.73)and high PLR(≥117.78)],1[either high NLR or high PLR],and 0[neither high NLR nor high PLR].Statistical analyses were conducted using SPSS 20.0 *** results showed that the preoperative NLR or PLR values,lower or higher,could not predict the LNM in patients with EGC(both P=0.5440.05).The invasive depth of tumor was significantly correlated with LNM of EGC(P〈0.001).Kaplan-Meier plots illustrated that preoperative NLR and PLR values were not associated with overall survival(OS)in patients with *** was concluded that the preoperative NLR and PLR may be the predictors for LNM and prognosis in patients with advanced gastric cancer;nevertheless,they cannot predict LNM and prognosis in patients with EGC.

关键词： early gastric cancer neutrophil lymphocyte ratio platelet lymphocyte ratio lymphnode metastasis prognosis

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Can the neutrophil-lymphocyte ratio, platelet-lymphocyte ratio and lymphocyte-monocyte ratio predict active bleeding in patients with upper gastrointestinal bleeding?

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Journal of Acute Disease 2021年第1期10卷 12-16页

作者： Cihan Bedel Mustafa Korkut Fatih Selvi Yusuf Karancı Department of Emergency Medicine Health Science University Antalya Training and Research HospitalAntalyaTurkey

Objective:To investigate the relationship between upper gastrointestinal bleeding and neutrophil-lymphocyte ratio(NLR),platelet-lymphocyte ratio(PLR),and lymphocyte-monocyte ratio(LMR),and examine whether they can be used as markers of ***:The retrospective single-center study included a total of 189 patients with upper gastrointestinal bleeding admitted to the tertiary emergency department between January 2018 and January ***,59 patients with similar demographic characteristics were selected as the control ***,42 patients with active bleeding and 147 patients without active bleeding were categorized into two groups according to their endoscopy *** NLR,PLR,LMR values,potential risk factors,and demographic characteristics were ***:The mean NLR levels were found significantly higher in the patient group compared to the control group(P<0.001),whereas the mean LMR levels were significantly lower in the patient group(P<0.001).The mean NLR and PLR levels were significantly higher in patients with active bleeding compared to those without active bleeding(P<0.001),whereas the mean LMR levels were significantly lower(P<0.001)for patients with active *** optimal cut-off value of NLR was found 2.1 for predicting uppergastrointestinal bleeding,with a sensitivity of 80.2%and specificity of 78.9%(AUC:0.840;P<0.001).Conclusions:NLR was determined to be a parameter that can be used as an indicator of active bleeding in patients with upper gastrointestinal bleeding.

关键词： Neutrophil lymphocyte ratio platelet lymphocyte ratio Upper gastrointestinal bleeding Emergency department

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Inflammatory response related scoring systems in assessing the prognosis of patients with pancreatic ductal adenocarcinoma:a systematic review

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Hepatobiliary & Pancreatic Diseases International 2014年第5期13卷 474-481页

作者： Jawad Ahmad Nathan Grimes Shahid Farid Gareth Morris-Stiff HPB Surgery Mater Hospital Department of Surgery Kettering General Hospital Department of Surgery Belfast City Hospital

BACKGROUND： Various scoring systems based on assessment of the systemic inflammatory response help assessing the prognosis of patients with pancreatic ductal *** the present systematic review we evaluated the validity of four pre-intervention scoring systems： Glasgow prognostic score（GPS） and its modified version（mGPS）, platelet lymphocyte ratio（PLR）, neutrophil lymphocyte ratio（NLR）, and prognostic nutrition index（PNI）.DATA SOURCES： MOOSE guidelines were followed and EMBASE and MEDLINE databases were searched for all published studies until September 2013 using comprehensive text word and MeSH terms. All identified studies were analyzed, and relevant studies were included in the systematic ***： Six studies were identified for GPS/mGPS with3 reporting statistical significance for GPS/mGPS on both univariate analysis（UVA） and multivariate analysis（MVA）.Two studies suggested prognostic significance on UVA but not MVA, and in the final study UVA failed to show *** studies evaluated the prognostic value of NLR. Six of them reported prognostic significance for NLR on UVA that persisted at MVA in 4 studies, and in the remaining 2 studies NLR was the only significant factor on UVA. In the remaining5 studies, all in patients undergoing resection, there was no significance on UVA. Seven studies evaluated PLR, with only one study demonstrated its prognostic significance on both UVAand MVA, the rest did not show the significance on UVA. Of the two studies identified for PNI, one demonstrated a statistically significant difference in survival on both UVA and MVA, and the other reported no significance for PNI on ***： Both GPS/mGPS and NLR may be useful but further better-designed studies are required to confirm their value. PLR might be little useful, and there are at present inadequate data to assess the prognostic value of PNI. At present, no scoring system is reliable enough to be accepted into routine use for the prognosi

关键词： pancreatic ductal adenocarcinoma Glasgow prognostic score modified Glasgow prognostic score platelet lymphocyte ratio neutrophil lymphocyte ratio prognostic nutrition index

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Neutrophil lymphocyte ratio as an Inflammatory Marker in Chronic Kidney Disease: Determinants and Correlates

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Open Journal of Nephrology 2022年第1期12卷 23-35页

作者： Peter Kehinde Uduagbamen Adesola Temitope Oyelese Abdallah Olukayode AdebolaYusuf Mary Umoh Thompson Boladale Ajani Afeez Alalade Osaze Ehioghae Division of Nephrology and Hypertension Department of Internal Medicine Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Department of Haematology and Blood Transfusion Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Division of Radiodiagnosis Department of Surgery Ben Carson (Snr) School of Medicine Babcock University/Babcock University Teaching Hospital Ilishan-Remo Nigeria Endocrine Diabetes and Metabolism Unit Department of Internal Medicine Federal Medical Centre Abeokuta Nigeria

Introduction: Inflammation has been implicated as a major reason for the higher morbidity and mortality in chronic kidney disease (CKD) compared to the diseases that commonly precedes it. The neutrophil lymphocyte ratio (NLR) has increasingly been reported to be a marker of systemic inflammation. We studied the neutrophil lymphocyte ratio and its relationship with kidney function and other markers of inflammation in health and in CKD. Methods: Two hundred and forty four participants in three cohorts: healthy, CKD stage 1 - 2 and, stage 3 - 4, were studied. Data of clinical, NLR, uric acid, urine albumin creatinine ratio (UACR), electrolytes were documented and independent associates of NLR were determined. Results: The NLR was higher in the CKD cohorts, P Conclusion: The NLR as an inflammatory marker is elevated in chronic kidney disease, and increases with disease severity hence it can be a useful tool in determining the presence and severity of inflammation in CKD.

关键词： Neutrophil lymphocyte ratio Inflammation Chronic Kidney Disease platelet lymphocyte ratio Hyperuricemia Albuminuria

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