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Successful treatment of severe monkeypox case with advanced HIV infection using plasma from smallpoxvaccinated healthy population:A case report

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iLABMED 2024年第1期2卷 60-66页

作者： Chuming Chen Weiming Yao Siran Huang Ling Peng Shiyan Feng Weibo Wu Yunlan Yi Zhiqiang Cheng Yang Yang Yan Yang Liuqing Yang Hongzhou Lu Fuxiang Wang Department of Infectious Diseases National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Department of Pathology National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina Department of Blood Transfusion National Clinical Research Center for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated HospitalSchool of MedicineSouthern University of Science and TechnologyShenzhenGuangdongChina

Since the first reported case of monkeypox in the UK in May 2022,there has been an upward trend in monkeypox cases and a global ***,reports of severe cases are relatively *** this study,we report a case of severe monkeypox in a patient with *** patient presented with skin lesions that started on his face and around the penis and persisted for several *** the course of the disease,he received systematic symp-tomatic supportive treatment,topical remedies,and special care for the *** also underwent cidofovir antiviral therapy and smallpox‐vaccinated healthy population‐derived plasma therapy in succession,with the condition ultimately showing improvement after plasma *** more than 3 months of hospitalization,he fully *** the best of our knowledge,this is the first reported use of smallpox‐vaccinated healthy population‐derived plasma in the treatment of severe monkeypox cases.

关键词： antiviral therapy co‐infection HIV monkeypox plasma therapy severe infection

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Update on hemolytic uremic syndrome:Diagnostic and therapeutic recommendations

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World Journal of Nephrology 2013年第3期2卷 56-76页

作者： Maurizio Salvadori Elisabetta Bertoni Renal Unit Careggi HospitalCareggi UniversityFlorence 50139Italy

Hemolytic uremic syndrome （HUS） is a rare disease. In this work the authors review the recent findings on HUS, considering the different etiologic and patho-genetic classifications. New findings in genetics and, in particular, mutations of genes that encode the complement-regulatory proteins have improved our understanding of atypical HUS. Similarly, the comple-ment proteins are clearly involved in all types of thrombotic microangiopathy： typical HUS, atypical HUS and thrombotic thrombocytopenic purpura （TTP）. Fur-thermore, several secondary HUS appear to be related to abnormalities in complement genes in predisposed patients. The authors highlight the therapeutic as-pects of this rare disease, examining both “traditional therapy” （including plasma therapy, kidney and kidney-liver transplantation） and “new therapies”. The latter include anti-Shiga-toxin antibodies and anti-C5 mono-clonal antibody “eculizumab”. Eculizumab has been recently launched for the treatment of the atypical HUS, but it appears to be effective in the treatment of typical HUS and in TTP. Future therapies are in phases Ⅰ and Ⅱ. They include anti-C5 antibodies, which are more purifed, less immunogenic and absorbed orally and, anti-C3 antibodies, which are more powerful, but potentially less safe. Additionally, infusions of recombinant complement-regulatory proteins are a potential future therapy.

关键词： Enterohemorrhagic Escherichia coli Diarrhea, Shiga toxin (Stx) 1 and Stx 2 Atypical hemolytic uremic syndrome Complement factors Thrombotic thrombocytopenic purpura Secondary thrombotic microangiopathy plasma therapy Eculizumab

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Immunological aspects of COVID-19:What do we know?

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World Journal of Biological Chemistry 2020年第2期11卷 14-29页

作者： Tsvetelina Veselinova Velikova Stanislav Vasilev Kotsev Daniel Stefanov Georgiev Hristiana Momchilova Batselova Department of Clinical Immunology University Hospital LozenetzSofia 1407Bulgaria Department of Infectious Diseases Pazardzhik Multiprofile Hospital for Active TreatmentPazardzhik 4400Bulgaria Dental Faculty Medical University of PlovdivPlovdiv 4002Bulgaria Department of Epidemiology and Disaster Medicine Medical UniversityPlovdivUniversity Hospital“St George”Plovdiv 4002Bulgaria

The newly emerged coronavirus(severe acute respiratory syndrome coronavirus 2 SARS-CoV-2)and the disease that it causes coronavirus disease 2019(COVID-19)have changed the world we ***,the origin and evolution of SARS-CoV-2 remain mostly *** virulence factors and immune mechanisms contribute to the deteriorating effects on the organism during SARS-CoV-2 *** humoral and cellular immune responses are involved in the pathophysiology of the disease,where the principal and effective immune response towards viral infection is the cell-mediated *** clinical picture of COVID-19,which includes immune memory and reinfection,remains unclear and ***,many hopes are put in developing an effective vaccine against the virus,and different therapeutic options have been implemented to find effective,even though not specific,treatment to the *** can assume that the interaction between the SARS-CoV-2 virus and the individual's immune system determines the onset and development of the disease significantly.

关键词： SARS-CoV-2 COVID-19 Immune memory Anti-SARS-CoV-2 antibodies COVID-19 treatment plasma therapy

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COVID-19 Vaccine

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Advances in Infectious Diseases 2020年第3期10卷 195-210页

作者： Zameer Shervani Intazam Khan Tasrina Khan Umair Yaqub Qazi Nanomaterials Production Division Food and Energy Security Research and Product Centre Sendai Japan Department of Neurology North Shore University Hospital Northwell Health Manhasset New York USA Department of Neurology and Neuroscience Weill Cornell Medical College New York USA Flushing Hospital Medical Center Flushing New York USA Biology Department University at Buffalo Buffalo USA Chemistry Department College of Science University of Hafar Al Batin Hafar Al Batin KSA

A number of companies have announced the vaccines for COVID-19 pandemic that has caused extreme poverty, famine, and more than a billion people have lost livelihood all across the globe. Mass production of vaccine Sputnik V is underway at different locations to inoculate population in Russia, Philippines, Vietnam, Brazil, Saudi Arab, and United Arab Emirates (UAE), and India. mRNA based vaccine of Pfizer-BioNTech after passing phase 2 trial is ready for testing on thousands of volunteers. Oxford University-AstraZeneca vaccine is also under phase 3 trial in US, Brazil, and India. In September, Novavax Inc.’s vaccine will be ready for phase 3 trial. By early next year, two billions of doses will be ready of Novavax. Moderna Therapeutics conducting vaccine trial on 30 thousands volunteers, results will be known soon. Hundreds of thousand volunteers have registered already for vaccination in US and other parts of the world. SinoVac Biotech Ltd. has prepared a vaccine “CoronaVac” and inoculating volunteers in Indonesia and Brazil. CanSino Biologics Inc. in phase 2 trial on 508 volunteers found a satisfactory immune response to COVID-19 virus. Apart from vaccine preparation and availability, we provided data for therapy and treatment for COVID-19 and transmission and stability aspect of COVID-19 SARS-Cov-2 virus. The data and results presented in this article are very important and useful in containing, treating, and eliminating the pandemic COVID-19.

关键词： COVID-19 Vaccine plasma therapy COVID-19 Transmission SARS-Cov-2 in Feces COVID-19 in Pets Community Transmission Super Spreader

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