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Effect of Bushen Yiqi Huoxue Recipe on placental Vasculature in Pregnant Rats with Fetal Growth Restriction Induced by Passive Smoking

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2013年第2期33卷 293-302页

作者：陈镇燕李婧黄光英 Institute of Integrated Traditional Chinese and Western Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

Interactions of vascular endothelial growth factor （VEGF） with receptors VEGFR1/Fltl and VEGFR2/Flk1, and those of angiopoietins （Ang-1, Ang-2） with receptor Tie2 play important roles in placental angiogenesis. This study investigated vascular morphology and expression of these angiogenic factors in rat placenta on the day 15, 18, 21 of gestation （D 15, D 18 and D21）. The rats were randomly assigned into 3 groups： normal group, model group [fetal growth restriction （FGR） model], and Bushen Tqi Huoxue （BYHR） recipe treatment group （BYHR group, the pregnant rats with FGR were treated with BYHR recipe）. Morphological analysis indicated that during initial villous formation, fetal nucle- ated erythrocytes （FNEs） appeared in maternal blood sinus （MBS）. Subsequently, FNEs were sur- rounded by endothelial cells to form fetal capillary （FC） and then by trophoblast cells to form villi. As pregnancy proceeded, FC density increased progressively with increasing endothelial identification staining （EIS） in normal and BYHR groups. Whereas, villous formation was suppressed, normal in- crease in FC density was impaired and EIS was weakened in model group. Quantitative PCR analysis showed that VEGF and Flkl mRNA increased over gestation in all groups, indicating that VEGF might play a pivotal role in FC growth during late gestation. VEGF mRNA was increased on D15, while de- creased on D21 in model group as compared with normal group and BYHR group. Immunohistochemi- cally, Ang-2 protein was highly expressed in FNEs, gradually disappeared as villi matured, and decreased over gestation in all groups, indicating that Ang-2 might play a pivotal role in villous formation, which was further supported by decreased Ang-2 mRNA and protein expression in model group on D 15. Ang-1 mRNA, Tie2 mRNA and Ang-1/Ang-2 ratio increased from D15 to D18 in all groups as placenta matured. Ang-1 mRNA, Tie2 mRNA and Ang-1/Ang-2 ratio were decreased on D18 in model group as compared with normal and BYHR gr

关键词： fetal growth restriction passive smoking placental angiogenesis vascular endothelial growth factor fms-like tyrosine kinase-1 fetal liver kinase-1 angiopoietin-1 angiopoietin-2 Tie2 Bushen Yiqi Huoxue recipe

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Effect of gestation dietary methionine-to-lysine ratio on methionine metabolism and antioxidant ability of high-prolific sows

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Animal Nutrition 2021年第3期7卷 849-858页

作者： Mao Xia Jie Peng Chenbin Cui Qiongyao Gu Linjie Zhou Chao Wang Haiqing Sun Jian Peng Hongkui Wei Department of Animal Nutrition and Feed Science College of Animal Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Innovation Institute of Healthy Fariming College of Animal Sciences and TechnologyZhongkai University of Agriculture and EngineeringGuangzhouGuangdong 510225China Department of Chemistry College of ScienceHuazhong Agricultural UniversityWuhan 430070China YangXiang Joint Stock Company Guigang 537000China

The uptake and metabolism of methionine(Met)are critical for epigenetic regulation,redox homeostasis,and embryo *** previous study showed that appropriate supplementation of dietary Met promoted the birth weight and placental angiogenesis of high-prolific *** further explore the metabolic effect of Met on pregnant sows,we have evaluated the influence of dietary Met level on Met metabolism,and the relationship between metabolites of Met and reproductive performance,antioxi-dant ability,and placental angiogenesis throughout the gestation of high-prolific *** sows(the 3rd parity,Large White)were randomly divided into 5 groups that were fed diets with standardized ileal digestible(SID)methionine-to-lysine(Met:Lys)ratios of 0.27(control),0.32,0.37,0.42,and 0.47 from the mating day(gestational d 0,G0d)until the farrowing ***-MS/MS analysis was used to simulta-neously evaluate the metabolites related to Met,e.g.S-adenosylmethionine(SAM),S-adenosylhomo-cysteine(SAH),homocysteine(Hcy),cysteine(Cys),and glutathione(GSH).The concentration of SAM and SAH in plasma had significant fluctuations,especially in late *** dietary Met sup-plementation significantly improved the plasma SAM and methylation potential(SAM-to-SAH ratio)at d 114 of pregnancy(G114d).Moreover,a positive association of the plasma SAM concentration at G114d was observed with the litter weight of born alive(Pplacental vascular density in the fold and stroma(P<0.05).Compared with the control group,the expression of vascular endothelial growth factor-A(VEGF-A)in the placenta tissue of 0.37 ratio group increased significantly(P<0.05).Collectively,these findings indicate that dietary Met:Lys ratio(0.37 to 0.57)in

关键词： Antioxidant ability Dietary methionine High-prolific sows Metabolism Reproductive performance placental angiogenesis

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