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Biomechanics of human optic chiasmal compression: ex vivo experiment and finite element modelling

Medicine in Novel Technology and Devices 2022年第1期13卷 110-117页

作者： Xiaofei Wang Andrew J.Neely Neeranjali S.Jain Swaranjali V.Jain Sanjiv Jain Murat Tahtali Gawn G.McIlwaine Christian J.Lueck Laboratory for Biomechanics and Mechanobiology of Ministry of Education Beijing Advanced Innovation Centre for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083China School of Engineering and Information Technology University of New South WalesCanberraAustralian Capital TerritoryAustralia Department of Neurology The Canberra HospitalCanberraAustralian Capital TerritoryAustralia Faculty of Medicine University of New South WalesKensingtonSydneyNew South WalesAustralia Department of Anatomical Pathology The Canberra HospitalCanberraAustralian Capital TerritoryAustralia Queen׳s University Belfast BelfastNorthern IrelandUK Belfast Health and Social Care Trust BelfastNorthern IrelandUK Australian National University Medical School CanberraAustralian Capital TerritoryAustralia Ophthalmic Engineering&Visual Science Laboratory School of Biological Science and Medical EngineeringBeihang UniversityRoom 424Building 537 Xueyuan RoadBeijing10083China

The mechanism of bitemporal hemianopia arising as a result of chiasmal compression is *** this study,we combined an ex vivo experiment and finite element modelling(FEM)to investigate its potential mechanism.A cadaveric human optic chiasm was scanned using micro-CT before and after deformation by inflation of Foley catheter,to simulate tumour growth from *** geometry of the same chiasm was reconstructed and simulated using finite element *** deformations were extracted from the simulation and compared with those observed during micro-CT *** addition,nerve fibre models examining variation in local fibre distribution patterns of the chiasm were incorporated to investigate the strain(deformation)distributions of the chiasm at an axonal *** FEM model matched the micro-CT scans well both qualitatively and *** of the chiasm induced high strains in the paracentral portions of the chiasm where the crossing optic nerve fibres are *** an axonal level,the magnitude of strains affecting crossed fibres were greater than those affecting uncrossed *** high strains in the paracentral portions of the chiasm,combined with the differences in strain between crossed and uncrossed nerve fibres,are consistent with a biomechanical explanation for the pattern of visual field loss seen in chiasmal compression.

关键词： Bitemporal hemianopia pituitary tumour Chiasm Finite element modelling Optic nerve fibre

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