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Clinical application of reserved gastric tube in neuroendoscopic endonasal surgery for pituitary tumor

World Journal of Clinical Oncology 2024年第3期15卷 411-418页

作者： Xi Chen Long-Yao Zhang Zhi-Feng Wang Yi Zhang Yu-Hua Yin Xue-Jian Wang Department of Nursing Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Neurosurgery Affiliated Hospital 2 of Nantong UniversityNantong 226000Jiangsu ProvinceChina Department of Neurosurgery Renji HospitalShanghai Jiao Tong UniversityShanghai 226000China

BACKGROUND The neuroendoscopic approach has the advantages of a clear operative field,convenient tumor removal,and less damage,and is the development direction of modern *** present,transnasal surgery for sphenoidal pituitary tumor is widely *** it has been found in clinical practice that some patients with this type of surgery may experience post-operative nausea and vomiting and other *** To explore the effect of reserved gastric tube application in the neuroendoscopic endonasal resection of pituitary *** A total of 60 patients who underwent pituitary adenoma resection via the endoscopic endonasal approach were selected and randomly divided into the experimental and control groups,with 30 in each *** group:After anesthesia,a gastric tube was placed through the mouth under direct vision using a visual laryngoscope,and the fluid accumulated in the oropharynx was suctioned intermittently with low negative pressure throughout the whole process after nasal disinfection,during the operation,and when the patient recovered from *** group:Given the routine intraoperative care,no gastric tube was *** number of cases of nausea/vomiting/aspiration within 24 h post-operation was counted and compared between the two groups;the scores of pharyngalgia after waking up,6 h post-operation,and 24 h *** frequency of postoperative cerebrospinal fluid leakage and intracranial infection were *** hospitalization days of the two groups were statistically *** The times of postoperative nausea and vomiting in the experimental group were lower than that in the control group,and the difference in the incidence of nausea was statistically significant(P<0.05).After the patient woke up,the scores of sore throat 6 h after the operation and 24 h after operation were lower than those in the control group,and the difference was statistically significant(P<0.05).The number of cases of postope

关键词： Neuroendoscopy Endonasal approach pituitary tumor Reserved gastric tube Nausea Vomiting Aspiration Complications

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Predictive value of pituitary tumor morphology on outcomes and complications in endoscopic transsphenoidal surgery

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第4期8卷 321-329页

作者： Andrew T.Heffernan Joseph K.Han John Campbell James Reese William G.Day Joshua Edwards Ran V.Singh Wylie Zhu Kent K.Lam Department of Otolaryngology-Head and Neck Surgery Eastern Virginia Medical SchoolNorfolkVirginiaUSA Medical Center Radiologists NorfolkVirginiaUSA Department of Radiology Eastern Virginia Medical SchoolNorfolkVirginiaUSA Sentara Healthcare Analytics and Delivery Science Institute NorfolkVirginiaUSA Neurosurgical Associates NorfolkVirginiaUSA Sentara Neurosurgery Specialists NorfolkVirginiaUSA

Purpose:Endoscopic transsphenoidal surgery(ETSS)is an increasingly utilized approach for resection of pituitary *** studies have evaluated preoperative tumor size,location,and extent as prognostic factors for surgical *** is little data on the relationship between preoperative pituitary tumor radiographic morphology and surgical *** Design:Retrospective longitudinal ***:Single tertiary care *** and Methods:Preoperative magnetic resonance imaging and computed tomography scans from patients undergoing ETSS for pituitary tumor resections from 2007 to 2017 were retrospectively evaluated.A neuroradiologist classified these pituitary tumors into six morphologic groups,each defined by volume,dimensions,extension,and *** difficulty,rates of incomplete resection,and postoperative complications were then stratified in relation to the morphologic ***:pituitary tumors from 131 patients were classified from preoperative imaging into six characteristic morphologies:(1)microtumor,(2)round,(3)transverse oblong,(4)superior-inferior oblong,(5)bilobed,and(6)large *** that were characterized with the large lobulated,bilobed,and transverse oblong morphologies correlated with higher rates of postoperative evidence of residual tumor(70%,36%,and 47%,respectively,all Ppituitary tumors that can be determined from preoperative *** tumor morphologic groups are associated with varying degrees of gross tumor resection,complications,and surgical *** pituitary tumor morphology may aid surgeons in planning the extent of resection,need for complex closure,and patient counseling.

关键词： endoscopic transsphenoidal surgery morphology pituitary adenoma pituitary tumor surgical outcomes tumor shape

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Application and Care of Two Kinds of Sphenoid Sinus Packing Materials after pituitary tumor Resection with the Transnasal Endoscopic Approach

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Neuroscience & Medicine 2020年第4期11卷 130-141页

作者： Shuo Yang Qiyu Feng Huidan Zhu Zhihuan Zhou Ji Zhang Department of Neurosurgery State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Sun Yat-sen University Cancer Center Guangzhou China

Background: Neuroendoscopic transsphenoidal approach for resection of pituitary adenomas has the advantages of less damage, fewer complications, and a faster recovery than the traditional approach and has beening favored by neurosurgeons. However, there has no standard method of selecting suitable packing materials after the operation to relieve pain in patients and achieve the ideal hemostatic effect. We compared the postoperative complications and treatment effects of two different packing materials in patients with pituitary adenomas. Objective: To investigate the advantages and disadvantages of using a catheter balloon and iodoform gauze for hemostasis in patients undergoing pituitary tumor resection by neuroendoscopic transsphenoidal approach. Materials and Methods: We retrospectively analyzed these data of 48 cases treated with pituitary adenoma resection by the single nasal approach from January 2018 to October 2019 in Sun Yat-sen University Cancer Center. According to the type of sphenoid sinus packing material used, these patients were divided into balloon tamponade oppression group (24 cases) and tela iodoformum oppression group (24 cases), respectively. The balloon tamponade oppression group received catheter balloon tamponade oppression hemostasis, and the tela iodoformum oppression group underwent tela iodoformum oppression hemostasis. The outcomes and complications were compared between the two groups in which two kinds of sphenoid sinus packing materials were used for hemostasis after tumor resection by transnasal endoscopic approach. For the catheter balloon compression hemostasis method, on account of the plasticity of the balloon, the volume of water in the balloon can be adjusted according to the size of the patient’s own sphenoid cavity. The amount of bleeding and several complications in terms of discomfort during placement and

关键词： Sphenoid Sinus Packing Material pituitary tumor Nursing

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A systematic survey of LU domain-containing proteins reveals a novel human gene,LY6A,which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors

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Frontiers of Medicine 2023年第3期17卷 458-475页

作者： Dan Liu Chunhui Xu Yanting Liu Wen Ouyang Shaojian Lin Aining Xu Yuanliang Zhang Yinyin Xie Qiuhua Huang Weili Zhao Zhu Chen Lan Wang Saijuan Chen Jinyan Huang Zhe Bao Wu Xiaojian Sun Shanghai Institute of Hematology State Key Laboratory of Medical GenomicsNational Research Center for Translational Medicine at ShanghaiRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Systems Biomedicine Ministry of EducationShanghai Center for Systems BiomedicineShanghai Jiao Tong UniversityShanghai 200240China CAS Key Laboratory of Tissue Microenvironment and tumor Shanghai Institute of Nutrition and HealthShanghai Institutes for Biological SciencesUniversity of Chinese Academy of SciencesChinese Academy of SciencesShanghai 200031China Department of Neurosurgery Center of Pituitary TumorRuijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Biomedical Big Data Center First Affiliated HospitalZhejiang University School of Medicineand Cancer CenterZhejiang UniversityHangzhou 310000China Department of Neurosurgery First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000China

The Ly-6 and uPAR(LU)domain-containing proteins represent a large family of cell-surface *** particular,mouse Ly-6A/Sca-1 is a widely used marker for various stem cells;however,its human ortholog is *** this study,based on a systematic survey and comparative genomic study of mouse and human LU domain-containing proteins,we identified a previously unannotated human gene encoding the candidate ortholog of mouse Ly-6A/*** gene,hereby named LY6A,reversely overlaps with a lncRNA gene in the majority of exonic *** found that LY6A is aberrantly expressed in pituitary tumors,but not in normal pituitary tissues,and may contribute to *** to mouse Ly-6A/Sca-1,human LY6A is also upregulated by interferon,suggesting a conserved transcriptional regulatory mechanism between humans and *** cloned the full-length LY6A cDNA,whose encoded protein sequence,domain architecture,and exon‒intron structures are all well conserved with mouse Ly-6A/*** expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell ***,these studies unveil a novel human gene encoding a candidate biomarker and provide an interesting model gene for studying gene regulatory and evolutionary mechanisms.

关键词： LU domain-containing protein family novel human gene LY6A pituitary tumor biomarker nonsynonymous SNP GPI-anchored protein

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EXPRESSION OF EPIDERMAL GROWTH FACTOR, TRANSFORMINGGROWTH FACTOR-α AND THEIR RECEPTOR IN HUMAN pituitary tumorS

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Chinese Journal of Cancer Research 2001年第3期13卷 206-207页

作者：张龙雷霆薛德麟 Department of Neurosurgery Tongji Hospital Tongji Medical University Wuhan

Objective: To explore the role of growth factor autocrine stimulation in the pathogenesis of human pituitary tumors. Methods: The expression of EGF, TGF-( and EGFR were studied by immunohisto-chemical method on paraffin-embedded sections of 30 cases pituitary tumor. Results: EGFR and its ligands EGF, TGF-( expressed in majority of pituitary tumors. The expression of EGFR and its ligands varied with cells' intensity, density and type. Conclusion: The EGF autocrine stimulating exerted in the pituitary tumor development process, that tyrosine kinases inhibitors may be useful for pituitary tumors treatment.

关键词： pituitary tumor Epidermal growth factor Epidermal growth factor receptor Immunohisto-chemistry

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Carotid artery injury in endoscopic endonasal surgery: Risk factors, prevention, and management

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 54-60页

作者： Rahul K.Sharma Alexandria L.I race Jonathan B.Overdevest David A.Gudis Department of Otolaryngology-Head and Neck Surgery Columbia University Irving Medical CenterNewYork-Presbyterian HospitalNew YorkNew YorkUSA Department of Otolaryngology-Head and Neck Surgery Vanderbilt University Medical CenterNashvilleTennesseeUSA

Objective:Endoscopic approaches for sinus and skull base surgery are increasing in *** objective of this narrative review is to characterize risk factors for internal carotid artery injury in endoscopic endonasal surgery(EES),highlight preventative measures,and illustrate key management *** Sources:Comprehensive literature ***:Relevant literature was reviewed using PubMed/***:Carotid artery injury in EES is rare,with most studies reporting an incidence below 0.1%.Anatomic aberrancies,wide dissection margins,as well as specific provider and hospital factors,may increase the risk of *** teams,comprehensive preoperative imaging,patient risk assessment,and formal training in vascular emergencies may reduce the *** protocols should emphasize proper visualization of the injury site,fluid replacement,rapid packing,angiography,and endovascular techniques to achieve ***:While EES is a relatively safe procedure,carotid artery injury is a devastating complication that warrants full consideration in surgical *** preventative measures include identifying patients with notable risk factors and obtaining preoperative *** teams and management protocols are ultimately necessary to reduce morbidity and mortality.