检索结果-南通市图书馆

Journal of Traditional Chinese Medicine 2017年第4期37卷 486-495页

作者： Wang Yu Jiang Huili Meng Hong Li Jing Yang Xinjing Zhao Bingcong Yu Qiuyun Liang Xingchen Bao Tuya School of Acupuncture Moxibustion and Tuina Beijing University of Chinese Medicine School of Science Beijing Technology and Business University

OBJECTIVE: To investigate the antidepressant mechanism of acupuncture at the molecular level in the pituitary gland of rats exposed to chronic restraint stress(CRS).METHODS: Forty-eight rats were randomly divided into a control group(C), model group(M), fluoxetine group(F), and acupuncture group(A). CRS was induced in the model group by restraining rats for 28 days. Groups F and A were given fluoxetine administration and acupuncture intervention, respectively, 1 h before the CRS procedures were implemented. On the 29 th day, rat pituitary glands were harvested for RNA extraction and RNA-sequencing ***: Differentially expressed gene analysis identified 148, 87, and 179 response genes differen-tially expressed in group C vs group M, group F vs group M, and group A vs group M, respectively. Using Gene Ontology term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis, we identified the up-regulation of gene sets involved in extracellular space,receptor binding, and monoamine neurotransmitter metabolism, and the down-regulation of gene sets involved in immune response and inflammatory response as the prevailing transcriptomic signatures in the pituitary gland of rats treated with CRS,fluoxetine, or ***: Our findings suggest that acupuncture has a multitarget antidepressant effect at the molecular and behavioral levels.

关键词： Acupuncture Depression pituitary gland Gene ontology RNA, Behavior

Early hyperbaric oxygen therapy inhibits aquaporin 4 and adrenocorticotropic hormone expression in the pituitary gland of rabbits with blast-induced craniocerebral injury

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第22期7卷 1729-1735页

作者： Jian Huo Jiachuan Liu Jinbiao Wang Yongming Zhang Chunlin Wang Yanyan Yang WenjiangSun Shaonian Xu Department of Neurosurgery the 105 Hospital of Chinese PLAHefei 230032Anhui ProvinceChina

In the present study, rabbits were treated with hyperbaric oxygen for 1 hour after detonator-blastinduced craniocerebral injury. Immunohistochemistry showed significantly reduced aquaporin 4 expression and adrenocorticotropic hormone expression in the pituitary gland of rabbits with craniocerebral injury. Aquaporin 4 expression was positively correlated with adrenocorticotropic hormone expression. These findings indicate that early hyperbaric oxygen therapy may suppress adrenocorticotropic hormone secretion by inhibiting aquaporin 4 expression.

关键词： hyperbaric oxygen blast-induced injury craniocerebral injury aquaporin 4 pituitary gland adrenocorticotropic hormone

Gene Expression Changes in the pituitary gland of Rats Exposed to Electromagnetic Pulses

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2011年第5期24卷 560-568页

作者： QI YuHong LIANG Jun HIM YanPing DING GuiRong LIU JunYe SU XiaoMing GUO GuoZhen Department of Radiotherapy Tangdu HospitalFourth Military Medical UniversityXi＇an 710038ShaanxiChina Department of Radiotion Medicine Faculty of Preventive MedicineFourth Military Medical UniversityXi＇an 710032ShaanxiChina Department of Pathology Faculty of Preclinical MedicineFourth Military Medical UniversityXi＇an 710032ShaanxiChina

Objective We examined alterations in the expression of tumorigenesis‐related genes in the pituitary gland of rats exposed to electromagnetic pulses （EMP）.Methods The global gene expression profiles of the pituitary gland in EMP‐exposed and control groups were detected by cDNA microarray *** then validated and further investigated the reduced expression of two tumorigenesis‐related genes,Pten,and Jund,by assessing their mRNA and protein expression by quantitative real‐time‐PCR,western blotting,and immunohistochemistry in the pituitary gland of rats 6 months after exposure to *** EMP exposure induced genome‐wide gene expression changes in the rat pituitary *** was decreased expression of the Pten and Jund mRNAs and proteins in EMP‐exposed rats compared with in unexposed control *** EMP exposure alters the expression of tumorigenesis‐related genes in the pituitary *** tumorigenesis‐related genes are potentially involved in the development of pituitary gland tumors in rats.

关键词： Tumorigenesis Electromagnetic pulses pituitary gland Pten Jund

Establishing a protein expression profile database for the normal human pituitary gland using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2012年第36期7卷 2922-2928页

作者： Rong Xie Wei Xu Weimin Bao Hang Liu Luping Chen Yiwen Shen Jianhong Zhu Department of Neurosurgery Huashan HospitalFudan University Institution of Biological Medicine Fudan University

In this study, we selected adult normal pituitary gland tissues from six patients during operations for pituitary microadenomas via the transsphenoidal approach for extended normal pituitary tissue resection around the tumor, and analyzed the protein expression of human normal pituitary using two-dimensional high-performance liquid chromatography combined with LTQ-Orbitrap mass spectrometry proteomics technology. The ten most highly expressed proteins in normal human pituitary were： alpha 3 type VI collagen isoform 5 precursor （abundance among tall pituitary proteins 1.30%）, fibrinogen beta chain preproprotein （0.99%）, vimentin （0.73%）, prolactin （0.69%）, ATP synthase, H~ transporting and mitochondrial F1 complex beta subunit precursor （0.52%）, keratin I （0.49%）, growth hormone （0.45%）, carbonic anhydrase I （0.40%）, heat shock protein 90 kDa I （0.31%）, and annexin V （0.30%）. Based on the biological function classifications of these proteins, the top three categories by content were neuroendocrine proteins （abundance among all pituitary proteins, 40.1%）, catalytic and metabolic proteins （28.3%）, and cell signal transduction proteins （9.8%）. Based on cell positioning classification, the top three categories were cell organelle （24.5%） membrane （20.8%）, and cytoplasm （13.0%）. Based on biological process classification, the top three categories of proteins are involved in physiological processes （42.9%）, cellular processes （40.4%）, and regulation of biological processes （9.1%）. Our experimental findings indicate that a protein expression profile database of normal human pituitary can be precisely and efficiently established by proteomics technology.

关键词： two-dimensional high-performance liquid chromatography mass spectrum pituitary gland proteins proteomics hypophyseal tumor physiological function pathological mechanism

Microscopic examination of pituitary glands in cases of fatal accidental hypothermia

在线全文

学校读者我要写书评

暂无评论

Forensic Sciences Research 2017年第3期2卷 132-138页

作者： Elke Doberentz Burkhard Madea Institute of Forensic Medicine University of BonnBonnGermany

In cases of death caused by hypothermia,histological analysis can be used to determine the cause of *** histological alterations of the pituitary glands in hypothermia have been reported in the literature,including haemorrhage,hyperaemia and cellular vacuolization of cells in the anterior *** the present study,the validity of these morphological alterations as markers for fatal accidental hypothermia was investigated in autopsy material.A total of 34 pituitary glands in cases of verified fatal accidental hypothermia were examined histologically(haematoxylin and eosin,ferric,azan)and immunohistochemically(LCA,ACTH,C5b-9).The findings were compared with 61 cases in a control *** was found in 50.0%of the study group cases and 59.0% of the control group *** vacuolization was observed in one case(2.9%)in the study group and one case(1.6%)in the control *** or recent haemorrhage in the glandular tissue was never *** our study,the histopathological characteristics described in the literature as pathognomonic for hypothermia could not be ***,histological differences in the pituitary glands between fatal hypothermia cases and control group cases were not observed.

关键词： Forensic pathology adenohypophysis haemorrhage hypothermia hyperaemia pituitary gland vacuolization post-mortem examination

Morphological comparison and gonadotropins cell localization of mature female turbot and mouse pituitary

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Oceanology and Limnology 2023年第6期41卷 2418-2428页

作者： Yudong JIA Yunhong GAO Jinxing LIN Yellow Sea Fisheries Research Institute Chinese Academy of Fishery SciencesQingdao 266071China Shanghai Laboratory Animal Research Center Shanghai 201203China

Reproduction is subtlety regulated by the hypothalamic-pituitary-gonad(HPG)axis in *** gland is the center of the HPG axis,while pituitary gonadotropins follicle stimulating hormone(FSH)and luteinizing hormone(LH)were identified the key elements of the HPG axis in teleost and ***,cell lines,and gonadotropins cell localization of female turbot and mouse pituitary were determined at mature stage to illustrate the anatomical difference and cell characteristics in this *** show that turbot pituitary is chicken heart-shaped,dorsoventral,located on the ventral surface of the *** mouse pituitary is oval,located in the pituitary fossa of the sella turcica at the skull *** well-distinguished areas adenohypophysis(AH)and neurohypophysis(NH)in pituitary were identified in turbot and *** AH comprised the rostral pars distalis(RPD),proximal pars distalis(PPD),and pars intermedia(PI).NH was not pronounced and with finger-like protrusions into ***,mouse AH only comprised the pars distalis(PD)and *** distribution was *** main types of cells(acidophilic,basophilic,and chromophobic cells)were distributed in the mouse PD region,whereas appeared in the turbot PPD,RPD,and ***,the percentage of mouse chromophobic and basophilic cells was higher and lower than that of turbot,*** diameter of the aforementioned three cells in the mouse was significantly higher than ***β-and lhβ-immunoreactive signals were identified in turbot-distinct pituitary cells that primarily occupied the peripheral and central regions of ***,mouse fsh-and lh-immunoreactive cells were expressed in the same cells and present in the *** results demonstrate the significantly difference of pituitary morphology,cell lines and gonadotropins(fshβand lhβ)location in female turbot and *** differences help for fully understand the evolution and endocrinological functions of pituitary.

关键词： turbot mouse pituitary gland cell line gonadotropins

Effects of flavonoids from Semen Cuscutae on the reproductive system in male rats

在线全文

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2000年第2期2卷 99-102页

作者： Da-NianQIN Bai-RongSHE Yun-ChuSHE Jian-HongWANG DepartmentofPhysiology ShantouUniversitySchoolofMedicineShantou515031China JiangxiCollegeofTraditionalChineseMedicine Nanchang330006China

Aim: To evaluate the effects of the flavonoids extracted from the Semen Cuscutae (FSC) on the reproductive and en-docrine functions in male rats. Methods: (1) FSC were obtained from the semen of Cuscuta sinensis Lam throughsolvent extraction and polyamide columnar chromatography; (2) Effect of FSC on the reproductive organs was assessedin immature rats. Rats were administered FSC through gastric gavage at a dose of 300 mg/kg per day for 7 days and theweights of testis, epididymis, seminal vesicle and pituitary gland were then observed; (3) To observe the effect of FSCon the reproductive endocrine function: same dose level of FSC was given to male rats of different age groups for 7days; on day 8, the plasma testosterone (T), estradiol (E_2) and LH were determined by RIA, the specific binding ofLH was estimated and the testes were weighed. (4) Effect of FSC on LH secretion was assessed in vitro on culturedadenohypophysis. (5) Effect of FSC on T secretion was assessed in vitro on Leydig cell culture. Results: FSC in-creased the weights of testis, epididymis and pituitary gland, and stimulated T and LH secretion both in vitro and inimmature rats. Conclusion: FSC invigorates the reproductive system and reproductive endocrine function in male rats.

关键词： Cuscuta sinensis Leydig cell testosterone LH estradiol pituitary gland

Multisystem involvement Langerhans cell histiocytosis in an adult:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第20期8卷 4966-4974页

作者： Bei-Bei Wang Jun-Ru Ye Yun-Lei Li Yi Jin Zhong-Wei Chen Jian-Min Li Yu-Ping Li Department of Pulmonary and Critical Care Medicine The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Pathology Department The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina Radiology Department The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325000Zhejiang ProvinceChina

BACKGROUND Langerhans cell histiocytosis(LCH)is a rare condition wherein Langerhans cells proliferate abnormally,adversely impacting organs including lymph nodes,bones,skin,lungs,and pituitary *** LCH disease course varies widely among patients from a self-limiting condition to one that progresses rapidly and culminates in *** is uncommon for multisystem LCH to be observed in *** we describe a woman suffering from multi-system LCH *** SUMMARY A 37-year old Chinese woman was admitted to the hospital in June 2019 suffering from dyspnea that had progressed over the course of 5 *** medical history included:central diabetes insipidus(DI)that had been treated via radiotherapy,desmopressin acetate,and bromocriptine;bilateral pneumothorax with two surgeries having been performed to remove bullae;and autoimmune hepatitis that had been unsuccessfully treated using a combination of methylprednisolone and mycophenolate mofetil.A chest computed tomography(CT)scan revealed the presence of multiple pulmonary cysts of varying *** re-analyzed right pulmonary bullae samples that had been removed in 2014,performed a systematic 18 F-FDG PET/CT analysis,and convened a multidisciplinary medical team to diagnose and treat this *** a result,we were able to eventually diagnose this patient with LCH that was not associated with BRAF-V600 E *** We hope to emphasize the importance of systemic evaluation and of cooperation between multidisciplinary physicians with the goal of improving awareness and detection of this orphan disease.

关键词： Langerhans cell histiocytosis Lung pituitary gland Liver Case report

Hematotesticular barrier is altered from early stages of liver cirrhosis:Effect of insulin-like growth factor 1

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2004年第17期10卷 2529-2534页

作者： Inma Castilla-Cortázar Nieves Diez María García-Fernández Juan Enrique Puche Fernando Diez-Caballero Jorge Quiroga Matías Díaz-Sánchez Alberto Castilla Amelia Díaz Casares Isabel Varela-Nieto Jesǘs Prieto Salvador González-Barón Department of Human Physiology University of NavarraPamplonaNavarraSpain Department of Human physiologySchool of MedicineUniversity of MlagaMalagaSpain Department of Human Physiology University of NavarraPamplonaNavarraSpain Department of Human Physiology School of MedicineUniversity of MálagaMalagaSpain Instituto de Investigaciones Biomédicas "Alberto Sols" Consejo Superior de Investigaciones CientificasUniversidad Autónoma de Madrid (CSIC-UAM)MadridSpain Supported by the Spanish Program I+DSAF 99/0072 and SAF 2001/1672 Department of Internal Medicine Hospital SierrallanaTollelavega and School of MedicineUniversity of the Basque Country-Vitoria-GasteizSpain Instituto de Investigaciones Biomedicas"Alberto Sols"Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid(CSIC-UAM) MadridSpain Department of Internal Medicine Liver Unit University of Navarra PamplonaNavarraSpain

AIM:The pathogenesis of hypogonadism in liver cirrhosis is not well *** results from our laboratory showed that IGF-1 deficiency might play a pathogenetic role in hypogonadism of *** administration of IGF-1 for a short period of time reverted the testicular atrophy associated with advanced experimental cirrhosis. The aim of this study was to establish the historical progression of the described alterations in the testes, explore testicular morphology,histopathology,cellular proliferation,integrity of testicular barrier and hypophyso- gonadal axis in rats with no ascitic cirrhosis. METHODS:Male Wistar rats with histologically-proven cirrhosis induced with carbon tetrachloride(CCI_4)for 11 wk, were allocated into two groups(n=12,each)to receive recombinant IGF-1(2 μg/100 gd,sc)for two weeks or *** rats receiving vehicle were used as control group(n=12). RESULTS:Compared to controls,rats with compensated cirrhosis showed a normal testicular size and weight and very few histopathological testicular abnormalities. However,these animals showed a significant diminution of cellular proliferation and a reduction of testicular transferrin *** addition,pituitary-gonadal axis was altered,with significant higher levels of FSH(P<0.001 vscontrols)and increased levels of LH in untreated cirrhotic ***,IGF-1 treatment normalized testicular transferrin expression and cellular proliferation and reduced serum levels of LH(P=ns vs controls,and P<0.01 vs untreated cirrhotic group). CONCLUSION:The testicular barrier is altered from an early stage of cirrhosis,shown by a reduction of transferrin expression in Sertoli cells,a diminished cellular proliferation and an altered gonadal *** treatment with IGF-1 could be also useful in this initial stage of testicular disorder associated with compensated cirrhosis.

关键词： Animals Atrophy Carbon Tetrachloride Estrogens Follicle Stimulating Hormone Hypogonadism Insulin-Like Growth Factor I Liver Cirrhosis Luteinizing Hormone Male pituitary gland Rats Rats, Wistar Research Support, Non-U.S. Gov't Sertoli Cells Testis Testosterone Transferrin

Sellar and Suprasellar Granular Cell Tumor of Neurohypophysis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2017年第6期130卷 741-743页

作者： Hal-Long Liu Bo-Yuan Huang Ming-Shan Zhang Hao-Ran Wang Yan-Ming Qu Chun-Jiang Yu Department of Neurosurgery Sanbo Brain Hospital Capital Medical University Beijing 100093 China Cancer Biology Program Fox Chase Cancer Center Philadelphia PA 19111 USA

INTRODUCTION Granular cell tumor （GCT） of neurohypophysis was first reported by Boyce and Beadles in *** In 2016 WHO classification of central nervous system （CNS） tumors, GCT of neurohypophysis was defined as a distinct diagnosis.121 Here, we reported two cases of GCT of neurohypophysis misdiagnosed as pituitary adenoma and craniopharyngioma. One of the cases was a very rare fully described neurohypophysial GCT which invaded into the right cavernous sinus [Figure 1a and 1b], indicating that the benign tumor might possess aggressive features.

关键词： Granular Cell Tumor Pathology pituitary gland Posterior Therapeutics