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Open Journal of Orthopedics 2024年第1期14卷 32-40页

作者： Mir Sadat-Ali Department of Orthopaedic Surgery Haifa Medical Complex Al Khobar Kingdom of Saudi Arabia

Background: The growth and use of Artificial Intelligence (AI) in the medical field is rapidly rising. AI is exhibiting a practical tool in the healthcare industry in patient care. The objective of this current review is to assess and analyze the use of AI and its use in orthopedic practice, as well as its applications, limitations, and pitfalls. Methods: A review of all relevant databases such as EMBASE, Cochrane Database of Systematic Reviews, MEDLINE, Science Citation Index, Scopus, and Web of Science with keywords of AI, orthopedic surgery, applications, and drawbacks. All related articles on AI and orthopaedic practice were reviewed. A total of 3210 articles were included in the review. Results: The data from 351 studies were analyzed where in orthopedic surgery. AI is being used for diagnostic procedures, radiological diagnosis, models of clinical care, and utilization of hospital and bed resources. AI has also taken a chunk of share in assisted robotic orthopaedic surgery. Conclusions: AI has now become part of the orthopedic practice and will further increase its stake in the healthcare industry. Nonetheless, clinicians should remain aware of AI’s serious limitations and pitfalls and consider the drawbacks and errors in its use.

关键词： Artificial Intelligence Healthcare pitfalls Drawbacks

5-Bromo-2'-deoxyuridine labeling:historical perspectives,factors infiuencing the detection,toxicity,and its implications in the neurogenesis

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Neural Regeneration Research 2024年第2期19卷 302-308页

作者： Joaquín Martí-Clúa Unidad de Citología e Histología.Departament de Biologia Cel·lular de Fisiologia i d’Immunologia.Facultad de Biociencias.Institut de Neurociències.Universidad Autónoma de Barcelona08193 BellaterraBarcelonaSpain

The halopyrimidine 5-bromo-2′-deoxyuridine(BrdU)is an exogenous marker of DNA synthesis.Since the introduction of monoclonal antibodies against BrdU,an increasing number of methodologies have been used for the immunodetection of this synthesized bromine-tagged base analogue into replicating DNA.BrdU labeling is widely used for identifying neuron precursors and following their fate during the embryonic,perinatal,and adult neurogenesis in a variety of vertebrate species including birds,reptiles,and mammals.Due to BrdU toxicity,its incorporation into replicating DNA presents adverse consequences on the generation,survival,and settled patterns of cells.This may lead to false results and misinterpretation in the identification of proliferative neuroblasts.In this review,I will indicate the detrimental effects of this nucleoside during the development of the central nervous system,as well as the reliability of BrdU labeling to detect proliferating neuroblasts.Moreover,it will show factors influencing BrdU immunodetection and the contribution of this nucleoside to the study of prenatal,perinatal,and adult neurogenesis.Human adult neurogenesis will also be discussed.It is my hope that this review serves as a reference for those researchers who focused on detecting cells that are in the synthetic phase of the cell cycle.

关键词： 5-bromo-2′-deoxyuridine adult neurogenesis human adult neurogenesis labeling pitfalls prenatal neurogenesis proliferation S-phase suturing S-phase toxicity

Artificial Intelligence for Global Health: Difficulties and Challenges: A Narrative Review

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Open Journal of Epidemiology 2024年第1期14卷 122-130页

作者： Nazia S. Sadat Maryam S. Shuttari Mir Sadat-Ali Department of Applied Nutrition University of New England Portland USA Department of US Consultancy for Applied Research Lombard USA Department of Haifa Medical Center AlKhobar Saudi Arabia

Global health (GH) aims to improve healthcare for all people on the planet and eradicate all avoidable diseases and deaths. The inception of Artificial Intelligence (AI) is innovating healthcare practices and improving patient outcomes by shuffling enormous volumes of health data—from health records and clinical studies to genetic information analyzing it much faster than humans. AI also helps in the improvement of medical imaging and medical diagnosis. There is an increased optimism regarding the use of applications of AI locally but can these facets be translated globally in the advancement and delivery of healthcare with the help of AI. At present majority of AI developments and applications in health care provide to the needs of developed countries and there is little effort to develop programs which could help to improve healthcare delivery globally. We performed this narrative review to assess the difficulties and discrepancies in implementing AI in global health delivery and find ways to improve.

关键词： Artificial Intelligence Global Health Implementation pitfalls

pitfalls and optimal approaches to diagnose melioidosis

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Asian Pacific Journal of Tropical Medicine 2016年第6期9卷 501-510页

作者： Paul Vijay Kingsley Govindakarnavar Arunkumar Meghan Tipre Mark Leader Nalini Sathiakumar Sultan Ismail Hospital Manipal Center for Virus Research Manipal University School of Public Health University of Alabama at Birmingham

Melioidosis is a severe and fatal infectious disease in the tropics and subtropics. It presents as a febrile illness with protean manifestation ranging from chronic localized infection to acute fulminant septicemia with dissemination of infection to multiple organs characterized by abscesses. Pneumonia is the most common clinical presentation. Because of the wide range of clinical presentations, physicians may often misdiagnose and mistreat the disease for tuberculosis, pneumonia or other pyogenic infections. The purpose of this paper is to present common pitfalls in diagnosis and provide optimal approaches to enable early diagnosis and prompt treatment of melidoidosis. Melioidosis may occur beyond the boundaries of endemic areas. There is no pathognomonic feature specific to a diagnosis of melioidosis. In endemic areas, physicians need to expand the diagnostic work-up to include melioidosis when confronted with clinical scenarios of pyrexia of unknown origin, progressive pneumonia or sepsis. Radiological imaging is an integral part of the diagnostic workup. Knowledge of the modes of transmission and risk factors will add support in clinically suspected cases to initiate therapy. In situations of clinically highly probable or possible cases where laboratory bacteriological confirmation is not possible, applying evidence-based criteria and empirical treatment with antimicrobials is recommended. It is of prime importance that patients undergo the full course of antimicrobial therapy to avoid relapse and recurrence. Early diagnosis and appropriate management is crucial in reducing serious complications leading to high mortality, and in preventing recurrences of the disease. Thus, there is a crucial need for promoting awareness among physicians at all levels and for improved diagnostic microbiology services. Further, the need for making the disease notifiable and/or initiating melioidosis registries in endemic countries appears to be compelling.

关键词： Melioidosis pseudomallei Review Diagnosis Treatment pitfalls Approaches route of infection

The pitfalls in electrocatalytic nitrogen reduction for ammonia synthesis

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Journal of Energy Chemistry 2021年第10期30卷 149-154,I0005页

作者： Huimin Liu Néstor Guijarro Jingshan Luo Institute of Photoelectronic Thin Film Devices and Technology Solar Energy Research CenterKey Laboratory of Photoelectronic Thin Film Devices and Technology of TianjinMinistry of Education Engineering Research Center of Thin Film Photoelectronic TechnologyRenewable Energy Conversion and Storage CenterNankai UniversityTianjin 300350China Institute of Electrochemistry University of AlicanteAlicante E-03080Spain

Ammonia synthesis by electrocatalytic nitrogen reduction reaction(EC-NRR)has gained momentum in recent years fueled by its potential to operate at ambient conditions,unlike the highly energyintensive yet long-standing Haber-Bosch process.However,the large disparity of the yields and Faradic efficiencies reported for EC-NRR raises serious concerns about the reliability of the experimental results.In this perspective,we elaborate on the potential sources of error when assessing EC-NRR and update the testing protocols to circumvent them,and more importantly,we pose a general call for consensus on ammonia production analysis and reporting to lay the solid foundations that this burgeoning field requires to thrive.

关键词： Electrocatalytic nitrogen reduction Ammonia synthesis pitfalls Standard protocols

Transforaminal Percutaneous Endoscopic Discectomy using Transforaminal Endoscopic Spine System technique: pitfalls that a beginner should avoid

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World Journal of Orthopedics 2017年第12期8卷 874-880页

作者： Stylianos Kapetanakis Grigorios Gkasdaris Antonios G Angoules Panagiotis Givissis Spine Department and Deformities Interbalkan European Medical Center Department of Medical Laboratories Technological Educational Institute of Athens First Orthopaedic Department of "Aristotle University of Thessaloniki" "Papanikolaou" Hospital

Transforaminal Percutaneous Endoscopic Discectomy(TPED) is a minimally invasive technique mainly used for the treatment of lumbar disc herniation from a lateral approach. Performed under local anesthesia, TPED has been proven to be a safe and effective technique which has been also associated with shorter rehabilitation period, reduced blood loss, trauma, and scar tissue compared to conventional procedures. However, the procedure should be performed by a spine surgeon experienced in the specific technique and capable of recognizing or avoiding various challenging conditions. In this review, pitfalls that a novice surgeon has to be mindful of, are reported and analyzed.

关键词： Transforaminal Percutaneous Endoscopic Discectomy Transforaminal Endoscopic Spine System Lumbar disk herniation pitfalls Spine surgery

Current dilemma in photocatalytic CO_(2) reduction:real solar fuel production or false positive outcomings?

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碳中和(英文) 2022年第1期1卷 491-506页

作者： Kai Zhang Qi Gao Cuiping Xu Dawei Zhao Qibin Zhu Zhonghui Zhu Jin Wang Cong Liu Haitao Yu Chen Sun Xianglei Liu Yimin Xuan College of Energy and Power Engineering Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China Key Laboratory of Thermal Management and Energy Utilization of Aviation Vehicles Ministry of Industry and Information TechnologyNanjing 210016JiangsuChina

Solar driven carbon dioxide(CO_(2))recycling into hydrocarbon fuels using semiconductor photocatalysts offers an ideal energy conversion pathway to solve both the energy crisis and environmental degradation problems.However,the ubiquitous presence of carbonaceous contaminants in photocatalytic CO_(2) reduction system and the inferior yields of hydrocarbon fuels raise serious concerns about the reliability of the reported experimental results.Here in this perspective,we focus on the accurate assessment of the CO_(2) reduction products,systemically discuss the possible sources of errors in the product quantification,elaborate the common mistakes spread in the analysis of reaction products obtained in 13CO_(2) labelling experiments,and further propose reliable protocols for reporting the results of these isotopic tracing experiments.Moreover,the challenges and cautions in the precise measurement of O_(2) evolution rate are also depicted,and the amplification of the concentration of O_(2) in photoreactors well above the limit of detection is still demonstrated to be the most effective solution to this troublesome issue.We hope the viewpoints raised in this paper will help to assessment the reliability of the reported data in future,and also benefit the beginners that intend to dive in the photocatalytic CO_(2) reduction area.

关键词： Artificial photosynthesis Solar fuels Photocatalytic CO_(2)reduction pitfalls Isotopic tracing False positive results

Chronic Subdural Hematoma: pitfalls to Avoid for Better Outcome

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Open Journal of Modern Neurosurgery 2019年第4期9卷 419-428页

作者： Ahmed El Fiki Ahmed Assem Department of Neurosurgery Cairo University Cairo Egypt

Introduction: Chronic subdural hematoma is one of the commonest intracranial haemorrhages that affect elderly. Headache and focal neurological deficits are among the commonest presentations. It carries excellent prognosis especially when evacuated probably on right timing. Recurrence rate ranging from 8% - 37% in literatures, we will highlight tricks during peri-operative period to have better outcome and decrease recurrence. Patients and methods: We operated 45 cases of chronic subdural hematoma in Cairo university emergencyhospital, during the period from November 2016 to December 2017;CT brain was done for all cases;clinical data were reported;burr hole evacuation was the standard technique. Suction drain with mild suction pressure was applied and hospital stay was 3 - 4 days after surgery. Patients were followed up to three months. Results: Forty-five patients were operated with 27 cases (60%) having their ages between 5th and 7th decades. Among Twenty-nine males and 16 females, eleven patients (25%) were confused;headache was observed in 12 patients, weakness in 31 cases (69%), dysphasia in two cases and two patients were on renal dialysis. Hypertension was associated as a comorbidity in 18 patients, diabetes mellitus in 11 patients, and smoking in 11 patients. Forty-two patients were discharged home within 3 - 4 days;two cases developed small-sized intra-cerebral hematoma, one case of wound infection, and excellent outcome for all cases on three months follow up visit. Conclusions: Chronic subdural hematoma is one of the commonest intra-cranial haemorrhages in elderly with excellent outcome if managed meticulously in right timing. Good control of co-morbidities, insuring slow clearing of hematoma fluid and staged closure technique are factors linked with better outcome. But larger studies are needed.

关键词： Chronic Subdural Hematoma pitfalls Avoidance

Trauma-induced“Macklin effect”with pneumothorax and large pneumomediastinum,disguised by allergy

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Frontiers of Medicine 2013年第3期7卷 386-388页

作者： Salomone Di Saverio Kenji Kawamukai Andrea Biscardi Silvia Villani Luca Zucchini Gregorio Tugnoli Departments of Emergency and Surgery Emergency Surgery and Trauma Surgery UnitTrauma CenterMaggiore Hospital-Bologna Local Health DistrictBolognaItaly Department of Thoracic Surgery Trauma CenterMaggiore HospitalBolognaItaly Accident and Emergency Trauma CenterMaggiore HospitalBolognaItaly

A 56-year-old man presented spontaneously to the Emergency Department complaining of facial and neck oedema after assumption of nonsteroidal anti-inflammatory drugs(NSAIDS).The triage nurse assigned the patient to Accident&Emergency(A&E)doctor as probable allergic reaction to NSAIDS.Chest X-ray(CXR),ordered after 24 hours,revealed a huge subcutaneous chest and neck emphysema without clearly visible pneumothorax.Subsequent chest CT scan showed a small left pneumothorax and a large amount of air in the mediastinum.The patient was conservatively treated since he was eupnoeic and hemodynamically stable.The pathophysiology of pneumomediastinum was first described by Macklin in 1939.The Macklin effect involves alveolar ruptures with air dissection along bronchovascular sheaths to the mediastinum.In this case the patient did not report in his history a recent blunt thoracic trauma and the initial suspicion of an allergic reaction has prevented physicians to immediately achieve the correct diagnosis.

关键词： thoracic trauma differential diagnosis critical care pneumothorax pneumomediastinum CT scan pitfalls lung and airways physiology

Challenges in diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2018年第19期24卷 2047-2060页

作者： Lulu Zhang Santosh Sanagapalli Alina Stoita Department of Gastroenterology St. Vincent's Hospital Sydney

Pancreatic cancer is a growing source of cancer related death, yet has poor survival rates which have not improved in the last few decades. Its high mortality rate is attributed to pancreatic cancer biology, difficulty in early diagnosis and the lack of standardised international guidelines in assessing suspicious pancreatic masses. This review aims to provide an update in the current state of play in pancreatic cancer diagnosis and to evaluate the benefits and limitations of available diagnostic technology. The main modalities discussed are imaging with computed tomography, magnetic resonance imaging, endoscopic ultrasound and positron emission tomography and tissue acquisition with fine needle aspiration. We also review the improvements in the techniques used for tissue acquisition and the opportunity for personalised cancer medicine. Screening of high risk individuals, promising biomarkers and common mimickers of pancreatic cancer are also explored, as well as suggestions for future research directions to allow for earlier detection of pancreatic cancer. Timely and accurate diagnosis of pancreatic cancer can lead to improvements in the current poor outcome of this disease.

关键词： Pancreatic cancer Diagnosis Challenges Imaging Biomarkers Screening Endoscopic ultrasound pitfalls