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Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 202-208页

作者： Huiyan Shi Chenzhi Hou Liqiang Gu Zhe Wei Hang Xing Meiyu Zhang Shixiao Wang Longshan Zhao Kaishun Bi Xiaohui Chen School of Pharmacy Shenyang Pharmaceutical UniversityShenyang 110016China School of Traditional Chinese Material Medica Shenyang Pharmaceutical UniversityShenyang 110016China

The present study was designed to investigate the influence of the pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury rats.A simple and efficient high performance liquid chromatography coupled with mass spectrometry(HPLC-MS)method was developed to determine methotrexate in rat plasma.Methotrexate and syringic acid(internal standard)were extracted from rat plasma samples by protein precipitation with acetonitrile.The analysis was performed on a CAPCELL PAK C18column(150 mm×4.6 mm,5μm)with acetonitrile and 5 mmol/l ammonium acetate aqueous(10:90,v/v).The linear range was 5.0×10-2to 100.0μg/ml for methotrexate.Other parameters were all within the acceptance criteria.The validated method was successfully applied the pharmacokinetic study of methotrexate between two methotrexate treated groups(with and without the pretreatment of piperazine ferulate).Compared with the methotrexate treated alone group,the pharmacokinetic parameters in the methotrexate with the pretreatment of piperazine ferulate group showed significantly lower MRT(0-t),MRT(0-∞) and T1/2.Results suggested that methotrexate can be rapidly eliminated,cleared or metabolized in rat blood,which might be related to the pretreatment of piperazine ferulate.The method provided deeper insights into rational clinical use of methotrexate with the pretreatment of piperazine ferulate on cancer patients with renal dysfunction.

关键词： Methotrexate piperazine ferulate Pharmacokinetic parameters HPLC-MS

Experimental studies and artificial neural network modeling of surface tension of aqueous sodium L-prolinate solutions and piperazine blends

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Chinese Journal of Chemical Engineering 2019年第8期27卷 1904-1911页

作者： Muhammad Shuaib Shaikh A.M.Shariff M.A.Bustam Sahil Garg Khadija Qureshi Pervez Hameed Shaikh Inamullah Bhatti Department of Chemical Engineering Mehran University of Engineering&Technology JamshoroSindh 76062Pakistan CO2 Research Centre(CO2RES) Universiti Teknologi PETRONASBandar Seri Iskandar 32610PerakMalaysia School of Chemical Engineering The University of QueenslandSt Lucia 4072Australia Office of Research Innovation and Commercialization(ORIC) Mehran University of Engineering&Technology JamshoroSindh 76062Pakistan

The surface tension study is very crucial for the design of CO2 gas absorption contacting equipment. The significance of the surface tension has been increasing due to its consideration in various technological fields. This property influences the mass transfer and hydrodynamics of gas absorption systems, mainly multiphase systems, in which the interface between gas and liquid exists. Therefore, in this study, surface tension of aqueous solutions of sodium L-prolinate(SP) and piperazine(PZ) blends were measured at ten different temperatures from(298.15 to 343.15) K. The SP mass fractions were 0.10, 0.20, and 0.30;while the mass fractions of PZ were 0.02 and 0.05. The experimental results showed that the surface tension increase with increasing the mass fractions of SP and PZ in aqueous blends, and decrease linearly with rising temperature. The experimental data of surface tension were correlated by two empirical correlations as a function of temperature and mass fractions for estimating the predicted data using the optimized correlation coefficients. Moreover, the modeling of surface tension data was carried out using Artificial Neural Network(ANN) approach. The results obtianed from ANN modeling were compared with applied empirical correlation. It was found that the ANN approach outperformed the empirical correlation used in this study. Besides, a quantitative analysis of variation(ANOVA) was performed in order to determine the significance of data. The surface tension of aqueous SP and SP + PZ was also compared with various conventional solvents.

关键词： Surface tension L-Prolinate piperazine Correlation Prediction Neural network

Synthesis and photophysical properties of porphyrin-phthalocyanine heterodimer linked by piperazine

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Chinese Journal of Chemistry 1998年第2期16卷 97-108页

作者：李希友周庆复田宏健许慧君 Institute of Photographic Chemistry Chinese Academy of SciencesBeijing 100101China

A porphyrin-phthalocyanine heterodimer linked by piperazine has been synthesized and characterized by spectroscopic methods. UV-visible absorption spectra indicated the presence of weak intramolecular interaction between the two chromophores. Selective excitation of the porphyrin moiety leads to energy transfer process to the phthalocyanine subunit. Furthermore, on the bases of the solvent-dependent fluorescence data, a competing electron transfer reaction is shown to occur in this heterodimer. The efficiency of both photophysical processes depends strongly on solvent polarity and is related to the separation distance of the two chromophores and their relative orientation. The value of ΔG obtained using the Rehm-Weller equation clearly indicates that the heterodimer exists preferably in the “boat form” upon excitation in good agreement with the experimental results of co-occurence of energy and electron transfer process observed for the heterodimer.

关键词： Porphyrin phthalocyanine heterodimer piperazine photophysical property

Modeling the methyldiethanolamine-piperazine scrubbing system for CO2 removal： Thermodynamic analysis

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Frontiers of Chemical Science and Engineering 2016年第1期10卷 162-175页

作者： Stefania Moioli Laura A. Pellegrini Dipartimento di Chimica Materiali e Ingegneria Chimica 'G. Natta' Politecnico di Milano Piazza Leonardo da Vinci 32 1-20 33 Milano Italy

Aqueous solutions of methyldiethanolamine （MDEA） and piperazine （PZ） are commonly used solvent nowadays. In this work a thermodynamic analysis with the Electrolyte-NRTL model has been performed for systems composed of acidic gases and MDEA＋ PZ aqueous solution. ASPEN Plus＇s has been used for thermodynamic modeling. Values of binary interaction parameters for liquid phase activity coefficients have been estimated from regressions of experimental data. Moreover, the influence of the interactions between ion pairs and MDEA or PZ molecular species has been analyzed. The final aim is to obtain a reliable tool for design and simulation of absorption and stripping columns, fundamentals also in order to carry out energy saving studies.

关键词： vapor-liquid equilibrium methyldietanola- mine piperazine regression Electrolyte-NRTL

Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-piperazine Cocrystal

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Natural Products and Bioprospecting 2020年第4期10卷 261-267页

作者： Ningbo Gong Hongmei Yu Ying Wang Cheng Xing Kun Hu Guanhua Du Yang Lu Beijing Key Laboratory of Polymorphic Drugs Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China Beijing City Key Laboratory of Drug Target Identification and Drug Screening Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050China

A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized.The solid form was prepared by liquid assisted grinding,slurry and crystallization methods.The cocrystal was characterized by powder X-ray diffraction,differential scanning calorimetry,thermogravimetric analysis,Fourier transform infrared spectroscopy,and structure determined by single crystal X-ray diffraction,the hydrogen bonds formed into fish bone structure along the[010]direction and all the molecules packed into 3D layer structure along a axis.After formation of cocrystal,the solubility of diosgenin was improved,and the solubility value in 0.2%SDS solution was approximately 1.5 times as large as that of the parent material.

关键词： Diosgenin piperazine Cocrystal Characterization Solubility

Novel piperazine-based Gemini and Bola Surfactants

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Chinese Chemical Letters 2006年第5期17卷 621-624页

作者： Qing Shah ZHANG Hui Miao ZHANG Bing Nan GUO School of Chemical Engineering and the Environment Beijing Institute of Technology Beijing 100081

A series of piperazine-based Gemini and Bola surfactants were synthesized. Gemini 1 and 5 have well surface activities. Their critical micelle concentrations （cmc） is 6.47×10^-4 mol/L and 1.17×10^-3mol/L, respectively. Bola surfactants 2 and compound 3, possessing better water solubility, have lower surface activities. Calculation, carried out by MM2 energy minimization, showed that compound with more hydrophobic chains in a spacer of limited length is difficult to be synthesized.

关键词： Gemini surfactants Bola-amphiphiles piperazine synthesis surface tension.

Synthesis and biological activities of some fluorine- and piperazine-containing 1,2,4-triazole thione derivatives

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Chinese Chemical Letters 2016年第1期27卷 163-167页

作者： Li-Yuan Zhang Bao-Lei Wang Yi-Zhou Zhan Yan Zhang Xiao Zhang Zheng-Ming Li State Key Laboratory of Elemento-Organic Chemistry Collaborative Innovation Center of Chemical Science and Engineering Nankai University

A series of fluorine- and piperazine-containing 1,2,4-triazole thione derivatives were synthesized by the Mannich reaction of triazole intermediates with various substituted piperazines and formaldehyde in high yields. Structures of title compounds were confirmed by melting points, IR,~1H NMR,^（13）C NMR and elemental analysis. The preliminary bioassays for 17 novel title compounds showed that several compounds have significant fungicidal activity against Cercospora arachidicola, Physalospora piricola and Rhizoctonia cerealis at 50 mg/m L.

关键词： Triazole thione derivatives Fluorine piperazine Mannich base Biological activity

Phase Transfer Catalyzed Synthesis and Antibacterial Activity of Water-soluble S-Triazolo[3,4-b][1,3,4]thiadiazoles Containing piperazine Group

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Chinese Chemical Letters 2005年第10期16卷 1309-1312页

作者： Guo Qiang HU Wen Long HUANG Hai WANG Medicinal College of Henan Unversity Kaifeng 475001 China Pharmaceutical University Nanjing 210009 Academy of Military Medical Sciences Beijing 100850

6/3-（4-Chlorophenyl）-s-triazolo[3, 4-b][1, 3, 4]thiadiazoles （2,a-e） and （Sa-e） were synthesized respectively by intermolecular cyclization of 5-aryl / 4-chlorophenyl-4-amino-3- mercapto-1, 2, 4-triazoles （la-e） and （4） with 4-chlorobenzoic acid / aryl acids, which were condensed with piperazine under phase transfer catalyst TBAB to yield the corresponding free bases of monopiperazine derivatives and followed to form water-soluble salts （3a-e） and （6a-e） with hydrochloric acid in good yields. The in vitro biological results showed that piperazine group conjugated with the above fused heterocycles played an important role in antibacterial activity. The structures of novel compounds were confirmed by IR, ＇H NMR, MS and elemental analysis.

关键词： s-Triazolo[3,4-b]thiadiazole piperazine water-soluble antibacterial activity.

Poly(ethylene glycol)-supported piperazine——Synthesis and Application in Knoevenagel Condensation

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Chemical Research in Chinese Universities 2010年第2期26卷 263-267页

作者： WANG Cui-e JIN Jie ZHANG Min YU Shu-yan SHANG Yong-jia HU Jin-song College of Chemistry and Materials Science Anhui Key Laboratory of Functional Molecular SolidsAnhui Key Laboratory of Molecular Based Materials Anhui Normal University Wuhu 241000 P. R. China

A soluble, poly（ethylene glycol）-supported piperazine catalyst was prepared. This soluble catalyst efficiently catalyzes the Knoevenagel condensation of various aromatic aldehydes with diethyl malonate or ethyl acetoacetate in a homogeneous phase to afford the desired alkenes in good purity and yield with a facile work-up process. It was found that the polymer reagent could be repeatedly used at least four times without the too much loss of activity. The catalyst has shown a good activity, stability, and recycling capability.

关键词： piperazine Polymer-supported catalyst Knoevenagel condensation