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New amide alkaloids from piper longum fruits

Natural Products and Bioprospecting 2013年第6期3卷 277-281页

作者： Jun YANG Yao SU Ji-Feng LUO Wei GU Hong-Mei NIU Yan LI Yue-Hu WANG Chun-Lin LONG Key Laboratory of Economic Plants and Biotechnology Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Resources and Environmental Sciences Hebei Agricultural UniversityHebei 071000China State Key Laboratory of Phytochemisty and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China College of Life and Environmental Sciences Minzu University of ChinaBeijing 100081China

Three new amide alkaloids piperlongumamides A-C(1-3),together with 12 known ones(4-15),were isolated from the fruits of piper *** structures of the new isolates were determined using spectroscopic data *** activity of these amides against HL-60(human leukemia),A-549(human lung cancer),MCF-7(human breast cancer),SMMC-7721(human liver cancer)and SW480(human rectal cancer)cell lines were *** B(11)exhibited weak inhibitory activity against HL-60(IC_(50)=21.32μM),A-549(IC_(50)=23.82μM)and MCF-7(IC_(50)=16.58μM)cell lines.

关键词： piperaceae piper longum amide alkaloids piperlongumamides piperchabamide B cytotoxicity

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Augmented growth of long pepper in response to arbuscular mycorrhizal inoculation

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Journal of Forestry Research 2012年第2期23卷 339-344页

作者： R.K.Singh P.Gogoi Department of Botany Rajiv Gandhi UniversityItanagar-791112India Krishi Vigyan Kendra-Sylvan Hengbung villageKangpokpi-795129India

Arbuscular mycorrhizal （AM） technology is a soil-based fertilization practice for sustainable crop productivity. We evaluated six indigenous Arbuscular mycorrhizal fungi （AMF） strains for their symbiotic response with piper longum （long pepper）, a non-timber forest product holding promise as a commercial crop for its medicinal fruits and roots. piper saplings were raised in a 10 cm thick sand and soil mix inoculated with various AMF. Under field conditions, plants inoculated with AMF demonstrated better survival （〉80%） than non mycorrhizal plants （58%）. Almost all the studied AMF strains increased the plant growth, biomass and nutrient content （N and P） over the uninoculated control. Mycorrhizal inoculation with four AMF species, viz： Glomus fasciculatum, G. clarum, G. etunicatum and G. versiforme greatly enhanced long pepper growth both in the nursery and field conditions.

关键词： piper longum Arbuscular mycorrhizal fungi Survival Growth non-timber forest product

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Anti-neuroinflammatory activity of PLLE on suppression of microglial activation in PD models

Anti-neuroinflammatory activity of PLLE on suppression of mi...

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中国神经科学学会第十届全国学术会议

作者： Shan-Shan GAO Peng-Cheng QU Chun-Li DUAN Hui YANG Department of Neurobiology School of Basic MedicineCapital Medical University

Objective Parkinson’s disease（PD） is one of the most common neuro-degenerative diseases in central nervous *** evidence suggests a possible involvement of mitochondrial defect and oxidative stress in the dopaminergic neuron degeneration in Parkinson’s disease（PD）.Methods In this study,we treated BV2 with LPS to induce neuroinflammation *** level of protein was measured by western ***（1） PLLE attenuated LPS-induced microglia activation.（2） PLLE reduced the NADPH oxidase assembly and the production of ROS.（3）PLLE also reduced LPS-induced IL-1 beta *** addition,PLLE reduced LPS-induced COX- 2 expression and PGE2 production.（4） Furthermore,we found that PLLE reduced LPS-induced IκB degradation and nuclear translocation of nuclear transcription factor NF-kappa B p65 subunit,which regulating inflammatory protein *** PLLE protected experimental neuroinflammatory PD models mainly through suppression of microglial activation and inhibition of the microglia NF-kappa B signaling pathways.

关键词： Parkinson’s disease(PD) neuroinflammation microglia piper longum

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