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Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs(Sus scrofa)

Journal of Animal Science and Biotechnology 2021年第1期12卷 198-206页

作者： Rong Zhou Wenye Yao Chundi Xie Leixia Zhang Yangli Pei Hua Li Zheng Feng Yalan Yang Kui Li Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding Key Laboratory of Animal Molecular Design and Precise Breeding of Guangdong Higher Education InstitutesSchool of Life Science and EngineeringFoshan UniversityFoshan 528231GuangdongChina State Key Laboratory of Animal Nutrition Key Laboratory of Animal Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsInstitute of Animal ScienceChinese Academy of Agricultural SciencesBeijing 100193China.

Background: RNA editing is a widespread post-transcriptional modification mechanism in mammalian *** many editing sites have been identified in domestic pigs(Sus scrofa), little is known about the characteristics and dynamic regulation of RNA editing in the pineal gland(PG), a small neuroendocrine gland that synthesizes and secretes melatonin, which is primarily responsible to modulate sleep ***: This study analyzed the expression of adenosine-to-inosine(A-to-I) editing regulators and profiled the first dynamic A-to-I RNA editome during postnatal PG development. The results identified ADAR1 as the most abundantly expressed ADAR enzyme, which was down-regulated during postnatal PG development. Furthermore,47,284 high-confidence RNA editing sites were identified, the majority of which(93.6%) were of the canonical A-to-I editing type, followed by C-to-T editing. Analysis of its characteristics showed that the A-to-I editing sites mostly localized in SINE retrotransposons PRE-1/Pre0_SS. Moreover, a strong deficiency and preference for guanine nucleotides at positions of one base upstream or downstream were found, respectively. The overall editing level at the puberty stage was higher than at both infancy and adulthood stages. Additionally, genome-wide RNA editing was found to exhibit a dynamic stage-specific fashion(postnatally). Genes that underwent developmental changes in RNA editing were associated with catabolic processes as well as protein localization and transport functions,implying that RNA editing might be responsible for the molecular machineries of the postnatal developing ***, RNA editing in 3′-UTRs might regulate gene expression by influencing miRNA binding during PG ***: This study profiles the first comprehensive developmental RNA editome in the pig PG, which contributes to the understanding of the importance of post-transcriptionally mediated regulation during mammalian postnatal PG development. Mo

关键词： A-to-I Pig pineal gland Postnatal development RNA editing

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Molecular mechanisms of seasonal photoperiod effects of the pineal gland on the hippocampus in rats

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Journal of Traditional Chinese Medical Sciences 2021年第2期8卷 135-144页

作者： Qi Han Guowen Du Leilei Liu Lepeng Wang Wenna Li Hairong Zhang Yike Sun Pei Zhu Ruisen Hao Shuran Ma School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Background:Based on the theory of“five Zang-organs corresponding to the seasons”in traditional Chinese medicine(TCM),physiological functions including emotions vary with the *** aimed to investigate the seasonal photoperiod effects of melatonin(MT)released from the pineal gland on the MT receptor(MTR)-Gs/Gi-cyclic adenosine monophosphate(cAMP)-protein kinase A(PKA)-cAMP response element-binding protein(CREB)signaling pathway in the ***:Rats were divided into three groups:control,operation(surgery with pineal gland removal),and pseudo-operation groups(same surgery as operation group but without removing pineal gland),and fed at specific time across the four *** levels of MTR,adenylate cyclase(AC),cAMP,PKA,and CREB in the hippocampus were analyzed using *** concentrations of Gs and Gi were analyzed using Western *** expression of CREB mRNA was detected by ***:For intragroup comparisons,compared with spring,the levels of Gs/Gi in the control group were higher in summer,autumn,and winter(P=.009 in summer;Ppineal gland on the hippocampus and may underpin seasonal changes in *** can support the prevention and treatment of the seasonal onset of mental disorders,and enrich the theory of“five Zang-organs corresponding to the seasons”.

关键词： pineal gland Melatonin Hippocampus Photoperiod Signaling pathway

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Cross-talk between the pineal gland and immune system

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Chinese Medical Journal 1998年第1期111卷 7-11页

作者： Poon AM Liu ZM Pang SF Department of Physiology Faculty of Medcine The University of Hong Kong Hong Kong China

ＣｒｏｓｔａｌｋｂｅｔｗｅｅｎｔｈｅｐｉｎｅａｌｇｌａｎｄａｎｄｉｍｍｕｎｅｓｙｓｔｅｍＡ．Ｍ．Ｓ．Ｐｏｏｎ，Ｚ．Ｍ．ＬｉｕａｎｄＳ．Ｆ．ＰａｎｇＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｏｌｏｇｙ，ＦａｃｕｌｔｙｏｆＭｅ... 详细信息

ＣｒｏｓｔａｌｋｂｅｔｗｅｅｎｔｈｅｐｉｎｅａｌｇｌａｎｄａｎｄｉｍｍｕｎｅｓｙｓｔｅｍＡ．Ｍ．Ｓ．Ｐｏｏｎ，Ｚ．Ｍ．ＬｉｕａｎｄＳ．Ｆ．ＰａｎｇＤｅｐａｒｔｍｅｎｔｏｆＰｈｙｓｉｏｌｏｇｙ，ＦａｃｕｌｔｙｏｆＭｅｄｉｃｉｎｅ，ＴｈｅＵｎｉｖｅｒ?..

关键词： Animals Humans Immunity Melatonin pineal gland Research Support Non-U.S. Gov't

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Melatonin changes in the pineal gland of sleep-deprived rats following habenular nucleus lesion

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Neural Regeneration Research 2011年第9期6卷 681-685页

作者： Huijuan Jin Meiying Song Min Huang Manli Wang Hua Zhao Department of Physiology Norman Bethune College of Medicine Jifin University Changchun 130021 Jilin Province China

The habenular nucleus （Hb） is an important structure that regulates the function of the pineal gland which may affect melatonin content in the pineal gland after sleep deprivation （SD）. In the present study, high performance liquid chromatography showed that the melatonin content in the pineal gland was significantly reduced, and y-aminobutyric acid content in the Hb was significantly increased after SD. Furthermore, the melatonin content in the pineal gland was markedly reduced after Hb lesion under normal sleep and SD conditions. Immunohistochemistry showed that the number of Fos-positive neurons was significantly decreased in the lateral and medial Hb after SD. The findings demonstrate that the reduction of melatonin in the pineal gland after SD is related to decreased activity of Hb neurons, and that the Hb can regulate sleep-wake rhythm by influencing melatonin secretion in the pineal gland.

关键词： Habenular nucleus melatonin pineal gland sleep deprivation neural regeneration

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The Role of pineal gland in Regulating Circadian Corticosterone Rhythm and Its Mechanism

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Journal of Chinese Pharmaceutical Sciences 1995年第1期4卷 55-56页

作者： Feng Xu Jing-Cai Li and Kong-Chen MaChronopharmacology Laboratory, Shenyang Pharmaceutical University, Shenyang 110015

ＴｈｅＲｏｌｅｏｆＰｉｎｅａｌＧｌａｎｄｉｎＲｅｇｕｌａｔｉｎｇＣｉｒｃａｄｉａｎＣｏｒｔｉｃｏｓｔｅｒｏｎｅＲｈｙｔｈｍａｎｄＩｔｓＭｅｃｈａｎｉｓｍＦｏｒＭａｓｔｅｒ＇ｓＤｅｇｒｅｅ：ＦｅｎｇＸｕＳｕｐｅｒｖｉｓ... 详细信息

ＴｈｅＲｏｌｅｏｆＰｉｎｅａｌＧｌａｎｄｉｎＲｅｇｕｌａｔｉｎｇＣｉｒｃａｄｉａｎＣｏｒｔｉｃｏｓｔｅｒｏｎｅＲｈｙｔｈｍａｎｄＩｔｓＭｅｃｈａｎｉｓｍＦｏｒＭａｓｔｅｒ＇ｓＤｅｇｒｅｅ：ＦｅｎｇＸｕＳｕｐｅｒｖｉｓｏｒｓ：Ｐｒｏｆ．Ｊｉｎｇ－Ｃａｉ...

关键词： pineal gland Melatonin Corticosterone

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Influences of light-dark profile and pineal gland on hypnotic activity of melatonin

Influences of light-dark profile and pineal gland on hypnoti...

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2004全国时间生物医学学术会议

作者： Fang Wang1, Jing Cai Li1*, Chun Fu Wu2, Jing Yu Yang2, Ruo Ming Zhang1, Hui Fang Chai1 1 Chronobiology Laboratory, Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China, 110016 2 Neuropharmacology Laboratory, Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang, Liaoning, P. R. China, 110016

The influences of light-dark cycle and pineal gland on the hypnotic activity of melatonin in rats and mice were revealed in this paper. The results showed that melatonin significantly shortened time

关键词： Melatonin Hypnotic activity pineal gland

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Melatonin changes in the pineal gland of sleep deprived rats following habenular nucleus lesion

Melatonin changes in the pineal gland of sleep deprived rats...

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中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： Huijuan JIN,Meiying SONG,Min HUANG,Manli WANG,Hua ZHAO~* Department of Physiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,China

＜正＞Objective Sleep deprivation（SD） is considered a risk factor for various disorders involving behavior, emotion,attention,learning ability,and immunological *** has been reported that SD-induced physiological functional disturbances are associated with reduction of *** experiments unequivocally show that SD can lead to melatonin reduction in the pineal gland of ***,the underlying mechanism remains unknown. The habenular nucleus（Hb） is an important structure that regulates the function of the pineal gland,which may affect melatonin content in the pineal gland after *** the present study,we want to confirm that the reduction of melatonin in pineal gland after SD is related to the changed activity of the Hb,revealing a central mechanism of sleeping *** The content of melatonin in the pineal gland and the content of glutamate（Glu） andγ-aminobutyric acid（GABA） in the Hb were measured by high performance liquid *** number of Fos-positive neurons in the Hb was measured by *** In the present study,the melatonin content in the pineal gland was significantly reduced,and GABA content in the Hb was significantly increased after ***,the melatonin content in the pineal gland was markedly reduced after Hb lesion under normal sleep and SD *** number of Fos-positive neurons was significantly decreased in the lateral and medial Hb after *** The results demonstrate that the reduction of melatonin in the pineal gland after SD is related to decreased activity of Hb neurons,and that the Hb can regulate sleep-wake rhythm by influencing melatonin secretion in the pineal gland.

关键词： habenular nucleus melatonin pineal gland sleep deprivation rat

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Expression of Clock genes in the pineal glands of newborn rats with hypoxic-ischemic encephalopathy

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Neural Regeneration Research 2012年第28期7卷 2221-2226页

作者： Bin Sun Xing Feng Xin Ding Li Bao Yongfu Li Jun He Meifang Jin Division of Neonatology Affiliated Children's Hospital of Soochow University Suzhou 215003 Jiangsu Province China Department of General Pediatrics Yixing People's Hospital Yixing 214200 Jiangsu Province China Division of Neonatology Suzhou Municipal Hospital (Main Campus) Suzhou 215002 Jiangsu Province China Jiangsu Institute of Hematology and Blood Diseases First Affiliated Hospital of Soochow University Suzhou 215006 Jiangsu Province China

Clock genes are involved in circadian rhythm regulation, and surviving newborns with hypoxic-ischemic encephalopathy may present with sleep-wake cycle reversal. This study aimed to determine the expression of the clock genes Clock and Bmall, in the pineal gland of rats with hypoxic-ischemic brain damage. Results showed that levels of Clock mRNA v^re not significantly changed within 48 hours after cerebral hypoxia and ischemia. Expression levels of CLOCK and BMAL1 protein were significantly higher after 48 hours. The levels of Bmall mRNA reached a peak at 36 hours, but were significantly reduced at 48 hours. Experimental findings indicate that Clock and Bmall genes were indeed expressed in the pineal glands of neonatal rats. At the initial stage （within 36 hours） of hypoxic-ischemic brain damage, only slight changes in the expression levels of these two genes were detected, followed by significant changes at 36-48 hours. These changes may be associated with circadian rhythm disorder induced by hypoxic-ischemic brain damage.

关键词： brain hypoxia cerebral ischemia neonatal rats pineal gland Clock Bmall mRNA protein brain neural regeneration

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The role of pineal microRNA-325 in regulating circadian rhythms after neonatal hypoxic-ischemic brain damage

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Neural Regeneration Research 2021年第10期16卷 2071-2077页

作者： Ning Sha Hua-Wei Wang Bin Sun Min Gong Po Miao Xiao-Lu Jiang Xiao-Feng Yang Mei Li Li-Xiao Xu Chen-Xi Feng Yuan-Yuan Yang Jie Zhang Wen-Jing Zhu Yuan-Yuan Gao Xing Feng Xin Ding Soochow Key Laboratory of Prevention and Treatment of Child Brain injury Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics Affiliated Huai’an Hospital of Xuzhou Medical UniversityHuai’anJiangsu ProvinceChina Pediatrics Research Institute Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Pediatrics The First Affiliated Hospital of Soochow University(Dushuhu Branch)SuzhouJiangsu ProvinceChina Cambridge-SU Genomic Resource Center Soochow UniversitySuzhouJiangsu ProvinceChina Clinical Laboratory Children’s Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina

Circadian rhythm disorder is a common,but often neglected,consequence of neonatal hypoxic-ischemic brain damage(HIBD).However,the underlying molecular mechanisms remain largely *** previously showed that,in a rat model of HIBD,up-regulation of microRNA-325(miR-325)in the pineal gland is responsible for the suppression of Aanat,a key enzyme involved in melatonin synthesis and circadian rhythm *** better understand the mechanism by which miR-325 affects circadian rhythms in neonates with HIBD,we compared clinical samples from neonates with HIBD and samples from healthy neonates recruited from the First Affiliated Hospital of Soochow University(Dushuhu Branch)in *** found that circulating miR-325 levels correlated positively with the severity of sleep and circadian rhythm disorders in neonates with ***,a luciferase reporter gene assay revealed that LIM homeobox 3(LHX3)is a novel downstream target of *** addition,in miR-325 knock-down mice,the transcription factor LHX3 exhibited an miR-325-dependent circadian pattern of expression in the pineal *** established a neonatal mouse model of HIBD by performing doublelayer ligation of the left common carotid artery and exposing the pups to a low-oxygen environment for 2 ***3 mRNA expression was significantly down-regulated in these mice and partially rescued in miR-325 knockout mice subjected to the same ***,we showed that improvement in circadian rhythm-related behaviors in animals with HIBD was dependent on both miR-325 and *** together,our findings suggest that the miR-325-LHX3 axis is responsible for regulating circadian rhythms and provide novel insights into the identification of potential therapeutic targets for circadian rhythm disorders in patients with neonatal *** clinical trial was approved by Institutional Review Board of Children’s Hospital of Soochow University(approval No.2015028)on July 20,*** experiments were approved by An

关键词： brain injury circadian rhythm hypoxic-ischemic brain damage miRNA neonate pineal gland sleep transcription factor

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Monochromatic green light stimulation during incubation shortened the hatching time via pineal function in White Leghorn eggs

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Journal of Animal Science and Biotechnology 2021年第3期12卷 1226-1235页

作者： Panlin Wang Yanyan Sun Yunlei Li Jing Fan Yunhe Zong Adamu Mani Isa Lei Shi Yuanmei Wang Aixin Ni Pingzhuang Ge Linlin Jiang Shixiong Bian Hui Ma Zhengdong Yuan Xiaolin Liu Jilan Chen Institute of Animal Sciences Chinese Academy of Agricultural SciencesKey Laboratory of Animal(Poultry)Genetics Breeding and ReproductionMinistry of Agriculture and Rural AffairsBeijing 100193China College of Animal Science and Technology Northwest A&F UniversityYangling 712100China Beijing DQY Agricultural Science and Technology Co. Ltd.Beijing 100094China

Background:Effect of monochromatic green light illumination on embryo development has been reported in *** avian pineal gland is an important photo-endocrine organ formed by a mediodorsal protrusion during embryonic ***,the involvement of pineal gland in the light transduction process remains to be *** the present study,we investigated the influence of monochromatic green light on hatching time and explored the possible mechanism via pineal ***:A total of 600 eggs of White Leghorn(Shaver strain)were incubated under photoperiods of either 12 h of light and 12 h of darkness using monochromatic green light(12L:12D group)or 24 h of darkness(0L:24D group)for 18 *** to 0L:24D group,the green light stimulation shortened the hatching time without extending the hatch window or impairing *** liver of embryos incubated in the 12L:12D light condition was heavier than those of the 0L:24D group on d 21 post incubation which may be linked to the observed increase in the serum concentration of insulin-like growth factor 1(IGF-1);primary secretion of the *** structure analysis of pineal gland demonstrated that the light stimulation increased follicle area,wall thickness and lumen area on d 10 and d 12 post *** function analysis demonstrated that three clock related genes(brain and muscle ARNT-like-1,BMAL1;circadian locomotor output cycles kaput,CLOCK;and cryptochrome-1,CRY1)and a melatonin rate-limiting enzyme related gene(arylalkylamine N-acetyltransferase,AANAT)were rhythmically expressed in the pineal gland of the 12L:12D group,but not in the 0L:24D ***,the light stimulation also increased the concentration of melatonin(MT),which was linked to hepatocyte proliferation and IGF-1 secretion in previous ***:The 12L:12D monochromatic green light stimulation during incubation shortened hatching time without impairing hatching *** gland’s ear

关键词： Circadian rhythm Hatching time Insulin-like growth factor 1 Melatonin Monochromatic green light pineal gland

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